[Presence of excipients in pharmaceutical products in 3 sources of therapeutic information].

Abstract:

OBJECTIVE:To evaluate the level of agreement between information compiled from the Vademecum, the Pharmaceutical Catalogue and instruction leaflets on the four excipients most commonly used to prepare pharmaceutical products (saccharin, saccharose, lactose and ethanol). DESIGN:Descriptive study. SETTING:Primary care. PATIENTS AND OTHER PARTICIPANTS:658 orally administered preparations of pharmaceutical products were chosen. Their composition formulas in the Vademecum, Pharmaceutical Catalogue and instruction leaflets were compared with a theoretical model constructed as the most reliable source of information on excipients. RESULTS:Saccharin and saccharose were the most frequently described and quantified excipients, and lactose the least. Saccharin was quantified in 97.3% of cases in which it was used as an excipient, saccharose in 95%, ethanol in 91.4% and lactose in 17.5%. Saccharin is also the excipient which coincided most in the three sources examined, followed by saccharose, lactose and ethanol. The Vademecum did not state the presence of saccharose in 62% of preparations and of lactose in 39.7%. Instruction leaflets were the source with the lowest rate of failing to state the excipients. CONCLUSIONS:Saccharose and lactose are excipients frequently omitted from the composition of orally taken pharmaceutical products in the Vademecum. Instruction leaflets provide the most reliable source out of the three analysed. The need to make available for doctors simple texts, contributing more reliable and up-to-date information, is underlined.

journal_name

Aten Primaria

journal_title

Atencion primaria

authors

Altimiras J,Nieto-Hernández T,Buitrago F

subject

Has Abstract

pub_date

1996-09-15 00:00:00

pages

190-3

issue

4

eissn

0212-6567

issn

1578-1275

journal_volume

18

pub_type

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