[Fixed drug combinations in hypertension: a budget impact analysis for the Spanish Health System on the marketing of a fixed combination of olmesartan/amlodipine].

Abstract:

OBJECTIVE:To carry out a budget impact analysis (BIA) of olmesartan/amlodipine (20/5, 40/5 and 40/10mg) marketed as a fixed combination (FC) in its approved indication for the National Health System (NHS). DESIG:We developed a decision tree model in order to estimate usual hypertension treatment algorithm in Spanish clinical practice. SETTINGS:The BIA has been developed from the perspective of the NHS for a period of 3 years (years 2010-2012). PARTICIPANTS:Spanish hypertensive population ≥ 35 years old. INTERVENTIONS:Introduction into the market of a fixed combination (FC) olmesartan/amlodipine in Spain. PRIMARY MEASURES:Expected costs to be assumed by the Spanish NHS (RRP-VAT) for hypertensive population able to be treated with the FC versus currently assumed costs by the NHS with free combination olmesartan and amlodipine. RESULTS:Estimated pharmaceutical costs in hypertensive population treated with olmesartan and amlodipine (2 pills) would be €25.2M (1(st) year), €26.4M (2011), €27.6M (2012), with a total 3-year period of €79.2M. According to patient tree model, the population able to be treated with FC would be 71,283 patients (2010), with a growth rate of 4.8% in the successive years, which supposes an annual cost of €21.2M (2010), €21.8M (2011) and €22.4M (2012), with a total 3-year period of €65.4M. The BIA shows savings of €13.8M in a total 3-year period. CONCLUSION:The BIA of FC olmesartan/amlodipine could generate net savings of €13.8M for the NHS in the period ranging from years 2010 to 2012.

journal_name

Aten Primaria

journal_title

Atencion primaria

authors

Belén Ferro-Rey M,Roca-Cusachs A,Sicras-Mainar A,Alvarez-Martín C,de Salas-Cansado M

doi

10.1016/j.aprim.2010.04.017

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

345-55

issue

7

eissn

0212-6567

issn

1578-1275

pii

S0212-6567(10)00405-1

journal_volume

43

pub_type

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