Abstract：
:The functional effects of chronic administration of 60 mg kg-1 chloroquine or quinacrine given as daily intraperitoneal injections for 84 days on normal and denervated expansor secundariorum muscles, a smooth muscle from the wing of chicks wholly innervated by noradrenergic nerves, have been investigated. Administration of quinacrine, but not chloroquine, blocked responses to noradrenergic nerve stimulation. Surgical denervation abolished responses to nerve stimulation. Contraction of the expansor muscle induced by noradrenaline was not changed by chronic administration of chloroquine or quinacrine, and both drugs did not influence denervation supersensitivity of expansor muscles to noradrenaline. Expansor muscles were unresponsive to acetylcholine (ACh) and histamine, but muscles from chicks chronically treated with chloroquine and quinacrine were responsive to ACh and histamine. Denervation also restored the response of expansor muscles to ACh and histamine and the responses were greater for denervated muscles from chronically treated chicks; these changes were more marked with quinacrine. Expansor muscles were contracted by potassium chloride (KCl) and 5-hydroxytryptamine (5-HT), and chronic treatment increased the responsiveness of expansor muscles to KCl. Denervation increased the responsiveness of expansor muscles to KCl and 5-HT; this effect was more pronounced in denervated muscles from quinacrine-treated chicks. The findings indicate that chronic administration of quinacrine sensitizes smooth muscles to agonist drugs by blocking noradrenergic transmission to induce postjunctional changes and exerting a direct action on the smooth muscle; these actions are less pronounced with chloroquine administration.
journal_name
Physiol Behavjournal_title
Physiology & behaviorauthors
Lot TYdoi
10.1016/0031-9384(93)90121-usubject
Has Abstractpub_date
1993-08-01 00:00:00pages
345-9issue
2eissn
0031-9384issn
1873-507Xpii
0031-9384(93)90121-Ujournal_volume
54pub_type
杂志文章abstract：OBJECTIVE:Electroacupuncture (EA) as well as moxibustion stimulation has been reported to produce an excitatory effect on the gastrointestinal motility of the rat. Serotonergic neurons of the mioenteric and submucous plexus are major participants in the gastrointestinal physiology. Here, we compared the outcomes of the...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2004.07.003
更新日期：2004-10-15 00:00:00
abstract：OBJECTIVES:To examine the mechanism of 5-lipoxygenase (5-LO) in the learning and memory dysfunction in rats subjected to chronic unpredictable mild stress (CUMS). METHODS:Eighty rats were divided into eight groups: the 0.5% sodium carboxymethyl cellulose solution (NaCMC)-treated group, empty vector (LV-Mock)-treated g...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2016.09.010
更新日期：2016-12-01 00:00:00
abstract：:The present study used the context preexposure facilitation effect (CPFE) to examine long-term retention of incidental context learning in periweanling, adolescent and adult rats. The CPFE is a variant of contextual fear conditioning in which encoding the context representation, associating this representation with sh...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2014.12.033
更新日期：2015-09-01 00:00:00
abstract：:This study examined the time course of the effects of a high-fat diet and voluntary running exercise on rat skeletal muscle carnitine acyltransferase (CAT), beta-hydroxy-acyl-CoA dehydrogenase (HAD), and citrate synthase (CS) activities. Sixty male Long-Evans rats were randomly allocated to receive either a standard (...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(96)00522-7
更新日期：1997-05-01 00:00:00
abstract：:Dried bonito dashi is often used in Japanese cuisine with a number of documented positive health effects. Its major taste is thought to be umami, elicited by inosine 5'-monophosphate (IMP) and L-amino acids. Previously we found that lactic acid, a major component of dried bonito dashi, enhanced the contribution of man...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2018.11.016
更新日期：2019-02-01 00:00:00
abstract：:The effect of naloxone on food intake and activity levels was studied in the wolf (Canis lupus). Naloxone decreased food intake at both the 1 mg/kg and 5 mg/kg dose. There was no quantitative difference in the magnitude of the decrease in food intake produced by naloxone in winter or summer. Wolves ate significantly g...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(83)90134-8
更新日期：1983-03-01 00:00:00
abstract：:The efficacy of two different unconditioned stimuli (US) in producing conditioned taste aversion (CTA) was tested in rats after bilateral ibotenic acid (IBO) lesions of the gustatory nucleus of thalamus (TTAx) and the medial and lateral parabrachial nuclei (mPBNx, lPBNx). An initial study determined an equivalent dose...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2005.12.008
更新日期：2006-03-30 00:00:00
abstract：:Noise exposure during the critical period of postnatal development in rats results in anomalous processing of acoustic stimuli in the adult auditory system. In the present study, the behavioral consequences of an acute acoustic trauma in the critical period are assessed in adult rats using the acoustic startle reflex ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2010.12.010
更新日期：2011-03-28 00:00:00
abstract：:Electrical and chemical stimulation of specific parts of the paraventricular hypothalamus (PVH) and the adjacent hypothalamus induce self-grooming responses in the rat. The function of this hypothalamic grooming area (HGA) is not understood. The localization of the HGA in the hypothalamus suggests that grooming, a beh...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(94)00335-3
更新日期：1995-05-01 00:00:00
abstract：:Injections of ACTH or corticosterone into late pregnant mice from Days 14 to 21 did not alter testes weights or feminine copulatory behavior of male offspring in adulthood. However masculine copulatory behavior was significantly reduced. Because ACTH does not cross the placenta, alterations in sexual behavior of male ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90085-4
更新日期：1984-01-01 00:00:00
abstract：:The presence of FFA-mobilizing areas in the rabbit central nervous system was investigated by injecting minute amounts of 2-deoxyglucose, glucose or insulin directly into the cerebrospinal fluid of conscious, unrestrained rabbits. Intracerebroventricular administration of minute amounts (10 mg) of deoxyglucose to fed ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90109-h
更新日期：1990-03-01 00:00:00
abstract：:The P3(00) event-related brain potential (ERP) was elicited with an auditory discrimination paradigm under two response task conditions in which the probability of the target tone was always 0.20. Subjects either counted the occurrence of each target tone or pressed a button to the target in different conditions. No r...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(93)90018-b
更新日期：1993-01-01 00:00:00
abstract：:The present experiment tested the hypothesis that phantom limb pain amputees show a different pattern of psychophysiological reactivity to stress compared with painfree amputees. Six phantom limb pain (PLP) and five painfree upper-extremity amputees were administered two groups of tasks: stressful and relaxing. The me...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章
doi：10.1016/s0031-9384(99)00235-8
更新日期：2000-03-01 00:00:00
abstract：:Vagal afferents are a vital link between the peripheral tissue and central nervous system (CNS). There is an abundance of vagal afferents present within the proximal gastrointestinal tract which are responsible for monitoring and controlling gastrointestinal function. Whilst essential for maintaining homeostasis there...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2014.03.012
更新日期：2014-09-01 00:00:00
abstract：:The allostatic load model has been used to quantify the physiological costs of the body's response to repeated stressful demands and may provide a useful, integrative perspective on the various correlates of late-life depressive symptoms. We interviewed 125 Rochester, NY adults, ranging in age from 67 to 94 years. We ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2013.10.014
更新日期：2014-01-17 00:00:00
abstract：:The present study was carried out to investigate the effects of rboIL-1 beta, rboIL-2, and rboIFN-gamma on food intake and forestomach motility in conscious dwarf goats. The intravenous injection of rboIL-1 beta (1 micrograms kg-1) resulted in tachycardia and an immediate fever that reached peak values 45 and 180 min ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(92)90362-6
更新日期：1992-11-01 00:00:00
abstract：:Zebrafish (Danio rerio) have been widely used to study the molecular mechanisms of development including neurodevelopment. More recently, they have begun to be used to study neuropharmacology and neurotoxicology. Critical for this line of research are methods to study behavioral function in zebrafish. Previous studies...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2008.07.009
更新日期：2008-10-20 00:00:00
abstract：:Self-grooming in response to the odors of conspecifics is a form of olfactory communication among meadow voles. The amount of time meadow voles spend self-grooming when they encounter the odors of conspecifics varies seasonally, with males targeting the odors of reproductively active females only during the breeding s...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2005.05.011
更新日期：2005-07-21 00:00:00
abstract：:Sleep and wake have a homeostatic relation that influences most aspects of physiology and waking behavior. Sleep disturbance has a detrimental effect on sleepiness and psychomotor vigilance. The purpose of this study was to identify which actual or perceived sleep characteristics accounted for the most variance in day...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2010.11.017
更新日期：2011-02-01 00:00:00
abstract：:The sensory properties of foods and beverages are primary determinants of food choice. Some flavor components have an inherent hedonic valence that influences ingestive behavior. However, these hedonic impressions may be modified and others newly formed through their association with the post-ingestive consequences of...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2011.10.028
更新日期：2012-11-05 00:00:00
abstract：:The purpose of the review is to highlight the influences of ambient temperature (T(a)) and caloric restriction (CR) on metabolism, cardiovascular function and behavior in mice. Standard vivarium ambient temperatures (T(a)?23 degrees C) are a mild cold stress for mice requiring elevated metabolic rate and food intake. ...
journal_title：Physiology & behavior
pub_type： 杂志文章,评审
doi：10.1016/j.physbeh.2004.04.025
更新日期：2004-07-01 00:00:00
abstract：:Prior work indicates that rats prefer a mixture of sucrose and maltodextrin to either carbohydrate alone. The present experiment examined whether a sucrose + maltodextrin (S + M) mixture also increases total fluid intake as does saccharin + carbohydrate mixtures. In 23 h/day, one-bottle tests male rats consumed more o...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(97)00478-2
更新日期：1998-02-15 00:00:00
abstract：:Behavioral and physiological consequences of heparinoid injections, which increase plasma levels of nonesterified fatty acids (NEFA) by releasing lipoproteinlipase into the circulation, were studied in rats, because, according to the lipostatic hypothesis of food intake control, changes in plasma metabolite levels sho...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(83)90046-x
更新日期：1983-01-01 00:00:00
abstract：:The present experiment investigated the effects of exposure to inescapable shocks (IS) on subsequent behavior in an elevated plus-maze and on shuttlebox-escape performance in male and female rats. In the elevated plus-maze, exposure to IS resulted in suppression of "total number of arm entries" and "rearings" in males...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(90)90302-k
更新日期：1990-10-01 00:00:00
abstract：:Recent evidence indicates that rats can learn to avoid aversive consequences of several hours of food deprivation by eating more of food having orosensory characteristics that predict a protracted fast. Two new studies tested if macronutrient composition of a flavoured meal before the reinforcing fast influences this ...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2006.02.007
更新日期：2006-06-15 00:00:00
abstract：:(-)-Hydroxycitric acid (HCA) reportedly promotes weight loss, in part, through suppression of hunger. However, this mechanism has never been evaluated in humans in a controlled study. Eighty-nine mildly overweight females were prescribed 5020-kJ diets for 12 weeks as part of a double-blind, placebo-controlled parallel...
journal_title：Physiology & behavior
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0031-9384(00)00321-8
更新日期：2000-10-01 00:00:00
abstract：:Tuco-tucos from Anillaco (Ctenomys aff. knighti), are subterranean rodents that run vigorously on laboratory wheels during the night but are active during the day in semi-natural enclosures, where they surface for foraging and burrow maintenance, under intense sunlight. Several studies have shown that light causes opp...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2019.112645
更新日期：2019-10-15 00:00:00
abstract：:Two peripheral signaling routes have been proposed to account for the ability of peripheral substances such as glucose to modulate memory processing in the brain. One possible signaling route is by crossing the blood-brain barrier to act directly on brain. A second route involves activation of peripheral nerves with r...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/s0031-9384(02)00850-8
更新日期：2002-11-01 00:00:00
abstract：:Female rats have a fertile postpartum estrus, which can result in a simultaneous gestation and lactation and later in the overlapping of two different-age litters. These different physiological and contextual situations may affect the maternal behavior of lactating rats and provoke long-lasting changes in the affectiv...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/j.physbeh.2008.02.004
更新日期：2008-03-18 00:00:00
abstract：:The aim of this study was to differentiate between maternal and offspring factors involved in the control of milk ingestion. Specifically, we investigated: (1) the temporal pattern of milk ingestion in fasted and non-fasted sucklings; (2) the amount of milk released as compared to that of milk available; and (3) the r...
journal_title：Physiology & behavior
pub_type： 杂志文章
doi：10.1016/0031-9384(84)90052-0
更新日期：1984-11-01 00:00:00
