Abstract：
:Substance P, a neuropeptide of the tachykinin group, inhibits measles virus replication in cell culture and partially blocks viral fusion activity assayed in the haemolysis system. The ID50 for the inhibition of measles virus single-cycle replication is 0.6 mumol/l, and the effect is fully reversible. The antiviral activity of substance P corresponds to that of previously described synthetic tri-to heptapeptides. Tachykinins and these oligopeptides share a short homology with the N-terminus of paramyxovirus fusion proteins.
journal_name
Acta Viroljournal_title
Acta virologicaauthors
Schroeder Csubject
Has Abstractpub_date
1986-09-01 00:00:00pages
432-5issue
5eissn
0001-723Xissn
1336-2305journal_volume
30pub_type
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