Abstract：
:We characterized leukocytes in peripheral blood of BALB/c mice infected with mouse herpesvirus isolate 72 (MHV-72) representing an isolate of mouse herpesvirus strain 68 (MHV-68, species Murid herpesvirus 4, genus Rhadinovirus, subfamily Gammaherpesvirinae, family Herpesviridae) (van Regenmortel et al., 2000). In acute infection (up to day 30 post infection (p.i.)) the number of CD8+ T cells increased, reaching a maximum at day 11 p.i. This increase correlated with that of CD4+ T, activated CD 19+ B and natural killer (NK) cells. At day 30 p.i. the numbers of CD4+, CD8+, CD14+ and CD19+ cells decreased to normal values. A similar increase in the number of these cells was observed at day 730 p. i. In the course of persistent infection (after day 30 p.i.) some of the mice developed a leukemia-like syndrome characterized by an increase in the number of leukocytes and appearance of atypical, blastic immature forms of leukocytes. The latter forms of leukocytes were characteristic by an increased amount of argyrophilic proteins. These results show further similarities between MHV-72 (another isolate of MHV-68) and EBV infections and justify the use of MHV-68 or MHV-72 as an appropriate mouse model for the study of EBV infection of humans.
journal_name
Acta Viroljournal_title
Acta virologicaauthors
Mrmusová M,Horváthová M,Klobusická M,Mistríková Jsubject
Has Abstractpub_date
2002-01-01 00:00:00pages
19-24issue
1eissn
0001-723Xissn
1336-2305journal_volume
46pub_type
杂志文章相关文献
ACTA VIROLOGICA文献大全abstract：KEYWORDS:virus sanitation; in vitro explants; antiviral mechanism; virus longevity. ...
journal_title：Acta virologica
pub_type： 杂志文章
doi：10.4149/av_2012_02_159
更新日期：2012-01-01 00:00:00
abstract：:Spleen cells from mice infected with human adenovirus type 6 (Ad6) showed defective interleukin 2 (IL2) production 3-5 days after the infection. The response of spleen cells to exogenous IL 2 was also deficient. The impaired capacity of concanavalin A--(Con A)-activated spleen cells from Ad6--infected mice to utilize ...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1991-08-01 00:00:00
abstract：:Cell-mediated reactions in measles cases, in direct contacts and healthy children were tested. Indices of phytohaemagglutinin-stimulated blastic transformation and leukocyte migration inhibition were evaluated. Positive reactions were found in the first and second weeks after manifestation of clinical symptoms. The ap...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1980-03-01 00:00:00
abstract：:A mathematical model of the pathogenesis of experimental Mengo virus infection in mice has been developed and fitted using kinetic data of both virus multiplication in different organs and mortality. The behaviour of the model proved to be bistable. In contrast to the widely accepted hypothesis that an acutely virus-i...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1987-08-01 00:00:00
abstract：:Mouse sera collected from day 4 to day 133 postinfection (p.i.) with phase I Coxiella burnetii strain Nine Mile were analysed by immunoblotting with phase I C. burnetii cell lysate. Antibodies of IgG class protein antigens were revealed already on day 10 p.i. (60, 49 and 27 kD proteins), followed by those to 77 kD pro...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:A method for the preparation of stable suspensions of erythrocytes sensitized with herpes simplex virus (HSV) antigen and for their use in the passive haemagglutination test (PHAT) was developed. Formolized sheep erythrocytes were treated with tannin and sensitized with HSV antigen prepared from infected chick embryo ...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1976-10-01 00:00:00
abstract：:Tomato yellow leaf curl disease causes severe losses in tomato production throughout Mediterranean countries including Tunisia. In order to generate engineered resistance to this disease, an intron-hairpin RNA construct harboring a Tomato yellow leaf curl Sardinia virus (TYLCSV) truncated replication-associated protei...
journal_title：Acta virologica
pub_type： 杂志文章
doi：10.4149/av_2009_02_99
更新日期：2009-01-01 00:00:00
abstract：:The presence and the level of hepatitis B surface antigen (HBsAg)/IgM complexes were determined in 54 chronic HBsAg carriers in relation to receptors for polymerized human serum albumin (pHSA-R) tested by specific radioimmunoassay, and to hepatitis B virus-DNA polymerase (HBV-DNAp). HBsAg/IgM complexes, correlated sig...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1987-03-01 00:00:00
abstract：:Two different radio-labeled nucleic acid probes, prepared from reverse transcription-polymerase chain reaction (RT-PCR) amplified variable region of VP2 and VP1 gene sequences of a highly virulent infectious bursal disease virus (IBDV), were tested for their ability to detect field isolates of IBDV directly in clinica...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：2000-10-01 00:00:00
abstract：:Five monoclonal antibodies (MoAbs) against Indian reference/vaccine strain of foot-and-mouth disease (FMD) virus subtype A22 (IND17/77) and a guinea pig antibody against a synthetic peptide representing amino acids (aa) 136-151 of VP1 polypeptide of A22 virus were used in the study. All the antibodies either failed to...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：:The activities, the temperature and pH optima of in vitro functioning and stability upon heating of virion transcriptase of 10 human influenza virus A strains differing in reactogenicity and isolated in different epidemiological situations, and of fowl plague virus (FVP) were compared. As compared with virion transcri...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1978-03-01 00:00:00
abstract：:The coat proteins of both ordinary (PVSO) and Andean (PVSA) strains were shown to be similar in molecular weights, peptide maps, amino acid analysis and reaction to a range of carlavirus antiseras. ...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：:A panel of 17 monoclonal antibodies (MAbs) against highly pathogenic avian influenza virus (HPAIV) A/Duck/Novosibirsk/56/05 A/H5N1 (subclade 2.2) isolated in Russian Federation was developed. Immunoblot analysis showed that 12 MAbs were specific for the hemagglutinin (HA) and 5 MAbs for nucleoprotein (NP). All anti-HA...
journal_title：Acta virologica
pub_type： 杂志文章
doi：10.4149/av_2011_01_3
更新日期：2011-01-01 00:00:00
abstract：:Alfalfa mosaic virus (AMV) was found to be transmitted through seeds of Nicandra physaloids L. The average seed transmission rate of the AMV isolates T6, LMBG-4 and ST amounted to 23, 4 and 0 per cent, repectively. In the cytoplasm of parenchyma cells of embryo cotyledons of seeds from plants infected with the T6 isol...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1977-07-01 00:00:00
abstract：:Histology of skin lesions and demonstration in them of Rickettsia conorii by direct immunofluorescence test (DIF) are presented in 13 patients with Mediterranean spotted fever (MSF). The lymphohistiocytic vasculitis which dominated the picture is not specific, however, it could be suggestive for the diagnosis of ricke...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1991-11-01 00:00:00
abstract：:Differences in interfering activities were demonstrated between low-passage epidemic and thermosensitive cold-adapted strains of influenza viruses A and B in experiments on chick embryos inoculated on the chorioallantoic membranes and on white mice. At a high multiplicity of infection the thermosensitive variants show...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1982-05-01 00:00:00
abstract：:Coxiella burnetii cells in both phase I and II reveal in sodium dodecylsulphate-polyacrylamide gel electrophoresis (SDS-PAGE) similar protein profiles with only small differences. C. burnetii protein profile in SDS-PAGE depended on the method of purification of C. burnetii cells from chick embryo yolk sacs. Immune mou...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:For the quantitative assay of selected togaviruses, suspensions of BHK cells were inoculated with virus and grown in spinner cultures. At intervals, dependent on the growth characteristics of the viruses, about 10(3) cells were centrifuged on to microscope slides and then stained with fluorescent antibody. For rapid d...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1979-07-01 00:00:00
abstract：:Over a 5-year observation period in a children-institution community, the severity of respiratory-syncytial (RS) virus infection varied within a broad range depending on biological properties of the circulating virus population. The type of virus population was characterized by a complex of biological features, namely...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1985-07-01 00:00:00
abstract：:Incubation of Aedes albopictus cells infected with Mayaro virus at 37 degrees C causes inhibition of virus replication. During the first hour post infection (p.i.) incubation at 37 degrees C inhibited cellular and virus proteosynthesis. A preferential translation of heat shock proteins 82 kD and 70 kD was observed. Af...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：:Influenza B viruses isolated in 1940, 1950 and 1970 belonged to antigenically remote subgroups according to the antigenic composition of haemagglutinin (HA). Antigenically related strains isolated in 1972-1976 differed by their reproduction capability, by their sensitivity to inhibitors in mammalian sera and by affini...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1983-09-01 00:00:00
abstract：:Transport properties of 9-(S)-(2,3-dihydroxypropyl) adenine (DHPA) in cell cultures were studied. Transport of DHPA into chick embryo (CE), ZP (a cell line derived from rabbit lungs) and HeLa cells reached equilibrium values after 10 min incubation. The concentration of intracellular DHPA varied from 30 to 50 per cent...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1983-03-01 00:00:00
abstract：:We isolated plaque-size variants of a South American strain of yellow fever virus, and compared their ability to infect orally and be transmitted by vector Aedes aegypti mosquitoes with that of the uncloned, parental virus. We analyzed the same clonal isolates in mouse virulence experiments. No significant differences...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1988-05-01 00:00:00
abstract：:The presence of interferon and type A immunoglobulins (IgA) was followed up in the nasopharyngeal washings collected from volunteers immunized intranasally with an inactivated influenza vaccine [strain A/Rom 1/73 (H3N2)]. Interferon was detected 24 hours after vaccine administration, its incidence being similar to tha...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1975-05-01 00:00:00
abstract：:Tick-borne viruses are causative agents of several important human diseases. Tick-borne encephalitis virus (TBEV) is the most prominent representative considered medically to be the most important arbovirus (arthropod-borne virus) in Europe and northern Asia. Tick-borne virus transmission cycles are determined by the ...
journal_title：Acta virologica
pub_type： 杂志文章,评审
doi：10.4149/av_2013_02_123
更新日期：2013-01-01 00:00:00
abstract：:In order to determine the definitive importance of T- and B-lymphocytes in immunity to Rickettsia conorii, mice genetically deficient in T-cells, B-cells, or both T- and B-cells were infected experimentally. T-lymphocytes rather than humoral antibodies were crucial to rickettsial clearance and a reduced mortality rate...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
abstract：:Sensitivity and specificity of a modified agar gel immuno-diffusion (AGID) test for the diagnosis of enzootic bovine leukosis was compared in 609 sera using the standard method, the modified test, and ELISA. The modifications concerned the composition of agar gel (1.8% Bacto-agar Difco), addition of polyethylene glyco...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1989-03-01 00:00:00
abstract：:Neonatal rat heart muscle primary cell cultures were infected with influenza A viruses. Depending on the infectious dose, functional and structural changes of the heart muscle cells could be registered. The system seems suitable for testing the cytotoxicity of different influenza virus strains. ...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：1985-12-01 00:00:00
abstract：:Studies on interaction between Herpes simplex virus 1 (HSV-1) and human fibroblasts KMB-17 have demonstrated that HSV-1 binding to the cell surface could induce a specific gene response. In this study, the HSV-1 stimulation-related gene 1 (HSRG1), a new so far unknown gene function of cellular response induced by a sp...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:In this study, DNA vaccines consisting of vector IRES-gD expressing Herpes simplex virus 1 (HSV-1) glycoprotein D (gD) and vector IRES-gD-IL-2 coexpressing HSV-1 gD and interleukin-2 (IL-2), respectively, were constructed. After intramuscular inoculation, both vaccines induced in BALB/c mice antibodies as assayed by E...
journal_title：Acta virologica
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
