Pharmacologic management of obsessive-compulsive disorder.

Abstract:

:Obsessive-compulsive disorder (OCD) is an intriguing, difficult problem characterized by anxiety-producing intrusive thoughts and performance of anxiety-reducing rituals. Current evidence suggests that OCD may be associated with dysregulation of serotonin and dopamine neurotransmission. Numerous early studies involving the serotonin-specific reuptake inhibitor clomipramine led to the formulation of this hypothesis. Positive results with clomipramine initiated further research with other serotonin-specific reuptake inhibitors, such as fluoxetine, fluvoxamine, sertraline, and serotonergic agents such as buspirone and trazodone. Findings from a number of clinical trials suggest that drugs that inhibit serotonin reuptake or affect serotonergic transmission in other ways are of clear benefit in the treatment of OCD. These drugs may be more effective for obsessive thoughts than for compulsive rituals. Effective pharmacotherapy can dramatically decrease obsessive-compulsive symptoms and improve the patient's quality of life.

journal_name

South Med J

journal_title

Southern medical journal

authors

Jackson CW,Morton WA,Lydiard RB

doi

10.1097/00007611-199403000-00003

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

310-21

issue

3

eissn

0038-4348

issn

1541-8243

journal_volume

87

pub_type

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