Abstract:
:Obsessive-compulsive disorder (OCD) is an intriguing, difficult problem characterized by anxiety-producing intrusive thoughts and performance of anxiety-reducing rituals. Current evidence suggests that OCD may be associated with dysregulation of serotonin and dopamine neurotransmission. Numerous early studies involving the serotonin-specific reuptake inhibitor clomipramine led to the formulation of this hypothesis. Positive results with clomipramine initiated further research with other serotonin-specific reuptake inhibitors, such as fluoxetine, fluvoxamine, sertraline, and serotonergic agents such as buspirone and trazodone. Findings from a number of clinical trials suggest that drugs that inhibit serotonin reuptake or affect serotonergic transmission in other ways are of clear benefit in the treatment of OCD. These drugs may be more effective for obsessive thoughts than for compulsive rituals. Effective pharmacotherapy can dramatically decrease obsessive-compulsive symptoms and improve the patient's quality of life.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Jackson CW,Morton WA,Lydiard RBdoi
10.1097/00007611-199403000-00003subject
Has Abstractpub_date
1994-03-01 00:00:00pages
310-21issue
3eissn
0038-4348issn
1541-8243journal_volume
87pub_type
杂志文章abstract::Payment systems in the US healthcare system have rewarded physicians for services and attempted to control healthcare spending, with rewards and penalties based upon projected goals for future spending. The incorporation of quality goals and alternatives to fee-for-service was introduced to replace the previous system...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000626
更新日期:2017-04-01 00:00:00
abstract::We have described a 38-year-old white American woman who had a 7-year history of pain in the left anterior chest, neck, right wrist, and buttocks. The pain fluctuated in severity and appeared to coincide with worsening of her skin condition, palmoplantar pustulosis (PPP). She manifested the typical skeletal features o...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199304000-00021
更新日期:1993-04-01 00:00:00
abstract::We report the first case ofextracranial tuberculous lymphadenitis which paradoxically developed during treatment of intracranial tuberculoma. Our patient, a 15-year-old girl who initially presented with meningitis and intracranial tuberculomas, developed extracranial tuberculomas during treatment for central nervous s...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000209091.57281.23
更新日期:2006-04-01 00:00:00
abstract::Nonmenstrual toxic shock syndrome (TSS) due to Staphylococcus aureus can lead to significant morbidity and mortality. While drotrecogin alfa (DA) has been employed in patients with Methicillin-resistant Staphylococcus aureus (MRSA) severe sepsis and septic shock, its utility in TSS remains unclear. The authors report ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000234646.27647.a6
更新日期:2006-11-01 00:00:00
abstract::Cardiac rupture due to blunt trauma has been recognized with increasing frequency over the past two decades. The mortality rate is high and the majority of patients die before they arrive at the emergency department. A high index of suspicion and prompt surgical intervention are crucial for survival. We report the man...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199707000-00019
更新日期:1997-07-01 00:00:00
abstract::The predictability of a method of determining serum digoxin concentration was assessed in a retrospective study of 35 hospitalized patients taking digoxin orally for maintenance therapy. Simple pharmacokinetic expressions were used to estimate digoxin concentration. Clinically, the mean measured digoxin concentration ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198403000-00016
更新日期:1984-03-01 00:00:00
abstract::Demonstration of clonality is supportive of a diagnosis of malignancy in cases of lymphoproliferative disorders. Determination of clonality at the molecular level is currently accomplished by Southern analysis; however, the polymerase chain reaction offers a potential alternative that is rapid, simple, and less expens...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199601000-00006
更新日期:1996-01-01 00:00:00
abstract:BACKGROUND:Chlamydia is the most commonly reported infectious disease in the United States, yet many women at risk for chlamydia infection are not being tested. METHODS:We conducted a chlamydia screening study (Phase I) and retrospective medical chart review (Phase II) of 199 women from 16 to 40 years of age attending...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000053673.13882.00
更新日期:2003-09-01 00:00:00
abstract::Endobronchial tuberculosis (EBTB) is an infection of the tracheobronchial tree. A 17-year-old male patient with tuberculosis who developed middle lobe syndrome on antituberculous treatment is presented. The patient was admitted with complaints of fever, cough and weight loss. Right paracardiac and perihilar heterogene...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181b66e7a
更新日期:2009-10-01 00:00:00
abstract::Blastomycosis in children is relatively infrequent. Further, osteomyelitis of the frontal bone, which prior to the antibiotic era occurred more frequently and was mostly due to pyogenic cocci, is rare today. We described a case of frontal osteomyelitis in a child due to blastomycosis which occurred in the absence of f...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197802000-00028
更新日期:1978-02-01 00:00:00
abstract::Lactulose is a poorly absorbed synthetic disaccharide frequently used in the treatment of portasystemic encephalopathy. Because lactulose syrup contains small amounts of absorbable sugars, it may cause hyperglycemia in diabetic individuals, but is usually well tolerated. We report the case of a patient with diet-contr...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199504000-00025
更新日期:1995-04-01 00:00:00
abstract::A 38-year-old African-American male complaining of pain in multiple joints was initially diagnosed with gouty arthritis concurrent with gonococcal septic arthritis. The diagnosis was made based on arthrocentesis results showing Gram-variable cocci and monosodium urate crystals in the synovial fluid. Final blood and sy...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31819ba3c0
更新日期:2009-04-01 00:00:00
abstract::The ability of Clonorchis sinensis to cause severe hepatobiliary disease is illustrated by the case we have reported, in which biliary obstruction and hepatic fibrosis resulted from the pathologic process associated with chronic clonorchiasis. Immunodiagnostic tests are currently limited, and diagnosis, as illustrated...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198707000-00030
更新日期:1987-07-01 00:00:00
abstract::Potentially serious iatrogenic hand injuries occurred in three patients in a general medicine practice. All resulted from technologic advances in patient care. Each resulted in substantial economic and emotional costs. One patient sustained a serious residual disability. Such injuries have rarely been reported in the ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198612000-00011
更新日期:1986-12-01 00:00:00
abstract:BACKGROUND:The effects of chronic diuretic use on serum homocysteine and its metabolic cofactors vitamin B6, vitamin B12, and red blood cell (RBC) folate have not been well studied. METHODS:Blood samples from 17 hypertensive patients receiving long-term diuretic therapy and 17 hypertensive patients not taking diuretic...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.1097/00007611-199909000-00003
更新日期:1999-09-01 00:00:00
abstract::To make informed career decisions, physicians must acquire a basic knowledge in medical management and health care economics as they evaluate the potential survival and growth of a primary care practice. Health care providers considering a specific community and local leaders and hospital administrators attempting to ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199404000-00006
更新日期:1994-04-01 00:00:00
abstract::With the intent of cost containment, we conducted a survey of cimetidine usage in the Ambulatory Care Service of our Veterans Administration Medical Center. During a period of six months, this drug was prescribed for 132 patients. Only about 20% received cimetidine for FDA approved conditions. Treated conditions not a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198410000-00019
更新日期:1984-10-01 00:00:00
abstract::We report a case of acute appendicitis with perforation associated with retained appendiceal barium. Abnormally retained barium may lead to appendicitis and this should be kept in mind when a barium-filled appendix is seen in an asymptomatic patient. Routine follow-up films on all patients whose appendix fills with ba...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198204000-00037
更新日期:1982-04-01 00:00:00
abstract:OBJECTIVES:Non-small-cell lung cancer (NSCLC) patient survival depends on a number of factors, including early diagnosis and initiation of treatment. Standard treatment options for patients with NSCLC include surgery, radiation therapy, and chemotherapy. The objective of this study was to evaluate the impact that the i...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000601
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:The Orthopaedic In-Training Examination (OITE) provides an objective way for both the residency program and the resident to monitor progress. METHODS:This longitudinal descriptive study tracks the OITE performance of 16 residents from one orthopaedic surgery residency program over nine years (1997-2005). Do...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31817c0ba6
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Surveys in recent years show that office emergencies are likely to occur in pediatric offices and that most offices are not equipped to deal with these situations. METHODS:To determine the pediatrician's preparedness to manage emergencies, we surveyed a randomly selected sample of 240 office-based pediatric...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199808000-00008
更新日期:1998-08-01 00:00:00
abstract::A 27-year-old man had recurrent abscesses of the thigh caused by organisms typical of mouth flora. The unusual identity of these organisms from a thigh abscess led to the recognition that the illness was induced by self-injection with saliva, and that the patient had many of the characteristics of Münchausen's syndrom...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1979-02-01 00:00:00
abstract::Penetrating neck trauma may be managed operatively or nonoperatively, depending on precise anatomic location. Conservative management of zone II injuries is currently an issue under debate. We present a brief case report followed by a description of the current strategies for operative exploration and diagnostic maneu...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract::A case of ruptured interstitial pregnancy is reported, along with review of the literature. Although sonography did not differentiate between interstitial and intrauterine pregnancy, I believe it will prove to be one of the most accurate diagnostic aids in detecting this condition. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198009000-00044
更新日期:1980-09-01 00:00:00
abstract::Radiation therapy and/or chemotherapy are the treatment modalities of choice in lymphomas. Except for Burkitt's tumor, surgery is usually indicated only when percutaneous biopsy fails to establish the histologic diagnosis. We have described a patient with glomerulonephritis and anasarca secondary to an IgM-producing p...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198211000-00030
更新日期:1982-11-01 00:00:00
abstract::A combined patient flow and work sampling study was done at the Ambulatory Pediatric Service of the Medical University of South Carolina. The biggest problem was that almost two thirds of the patient's time was spent waiting to see the doctor. Reasons for delay included too few examining rooms, the single block appoin...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197706000-00004
更新日期:1977-06-01 00:00:00
abstract::Buried bumper syndrome (BBS) is an uncommon complication of percutaneous endoscopic gastrostomy (PEG) tube placement. This unusual phenomenon occurs when the internal bumper of a PEG tube erodes and migrates through the gastric wall and becomes lodged anywhere between the gastric wall and the skin. If not removed and ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181fa73d0
更新日期:2010-12-01 00:00:00
abstract::Gastrointestinal side effects from nonsteroidal anti-inflammatory drugs (NSAIDs) result mainly from inhibition of the enzyme cyclooxygenase (COX)-1; it is responsible for the synthesis of prostaglandin E2, which leads to increased mucosal blood flow, increased bicarbonate secretion, and mucus production, thus protecti...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract::We have described a patient with portal hypertension and retrocardiac paramediastinal density on upright PA chest x-ray film. Splenoportograms showed this density to be paraesophageal collateral veins. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198511000-00030
更新日期:1985-11-01 00:00:00
abstract:BACKGROUND:Oxybutynin is a tertiary amine and has chemical similarities like protamine sulfate. Protamine sulfate's effect on bacterial viability has been shown in some studies; however, there is scanty data regarding the effect of oxybutynin on bacterial viability. Accordingly, the aim of the present study was to inve...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000305885.23903.71
更新日期:2008-03-01 00:00:00