Abstract:
BACKGROUND:The effects of chronic diuretic use on serum homocysteine and its metabolic cofactors vitamin B6, vitamin B12, and red blood cell (RBC) folate have not been well studied. METHODS:Blood samples from 17 hypertensive patients receiving long-term diuretic therapy and 17 hypertensive patients not taking diuretics were analyzed for serum homocysteine, vitamin B6, vitamin B12, and RBC folate. RESULTS:The mean serum homocysteine concentration for patients taking diuretics (17.87 +/- 1.72 micromol/L) was significantly higher than the mean serum homocysteine concentration for patients not taking diuretics (10.31 +/- 0.99 micromol/L). The mean RBC folate concentration for patients taking diuretics (281.01 +/- 17.56 ng/mL) was significantly lower than the mean RBC folate concentration for patients not taking diuretics (430.85 +/- 28.58 ng/mL). Serum vitamin B6 and vitamin B12 concentrations were not significantly different between the two groups. CONCLUSIONS:Chronic diuretic use is associated with a significant increase in serum homocysteine concentration, a significant decrease in RBC folate concentration, and no significant change in concentrations of vitamins B6 and B12.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Morrow LE,Grimsley EWdoi
10.1097/00007611-199909000-00003subject
Has Abstractpub_date
1999-09-01 00:00:00pages
866-70issue
9eissn
0038-4348issn
1541-8243journal_volume
92pub_type
临床试验,杂志文章abstract::Human monocytic ehrlichiosis (HME) is a tick-borne disease transmitted during the summer months in the mid-Atlantic, southeastern and south-central United States. A large proportion of patients presenting with ehrlichiosis must be hospitalized because of the severity of their presenting signs, symptoms and lab abnorma...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31804aa1ad
更新日期:2007-08-01 00:00:00
abstract::A patient with pathologically proven acrometastasis of his left thumb presented 3 months after esophagectomy for esophageal squamous cell carcinoma. Interestingly, there was indeed a faint uptake in his left thumb that was initially considered an artifact in the whole body bone scan taken before esophagectomy. Physici...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31817bf9be
更新日期:2008-11-01 00:00:00
abstract::We have described a 47-year-old white woman who had spontaneous E coli K1 meningitis after acquiring an E coli K1 urinary tract infection with associated sepsis. The patient's symptoms consisted only of severe headache, fever, and malaise. She had no meningeal or focal neurologic signs, and the CSF did not contain whi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198309000-00044
更新日期:1983-09-01 00:00:00
abstract:OBJECTIVES:To determine the documentation frequency of informed consent for women undergoing a trial of nonemergent instrumental delivery. STUDY DESIGN:A retrospective chart review of instrumented vaginal deliveries from 1992 to 2005 was performed. Cases were identified from a Labor and Delivery database and hospital ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000243076.86803.09
更新日期:2006-12-01 00:00:00
abstract::A 42-year-old woman had dysentery caused by the Shiga bacillus, Shigella dysenteriae type 1, while taking diphenoxylate with atropine during and after her return from a trip to Mexico. Although she was treated with appropriate antibiotics, she suffered a prolonged and toxic acute course followed by intermittent bouts ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198003000-00034
更新日期:1980-03-01 00:00:00
abstract::We report a rare case of Candida glabrata liver abscess and fungemia complicating severe calculus cholecystitis in a 64-year-old female patient who had no history of immunosuppression or diabetes mellitus. The patient underwent cholecystectomy, resection of liver abscess, and systemic antifungal therapy using micafung...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181c9803b
更新日期:2010-03-01 00:00:00
abstract::Each year an estimated 1.3 million Americans suffer eye injuries. There is little information in the literature regarding the prevalence, demographic characteristics, and prognosis of these patients. The Eye Injury Registry of Alabama (EIRA) serves as the first and only statewide system of its kind for the collection ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198707000-00004
更新日期:1987-07-01 00:00:00
abstract::Blastomycosis is an endemic systemic fungal infection that usually involves the lungs and superficial skin. Although head and neck involvement has been reported in the literature, no previous cases of neck mass resulting from direct extension of a pulmonary lesion have been published. We encountered an immunocompetent...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199810000-00009
更新日期:1998-10-01 00:00:00
abstract::Extramural programs may be evaluated in terms of effectiveness in achieving their particular goals. The components of structure, process, and outcome are examined as related sets of program elements. Goals influence appropriate structure in organization, facilities, and manpower. Structure in turn influences process o...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197906000-00027
更新日期:1979-06-01 00:00:00
abstract::Pulmonary arterial hypertension (PAH), a rare disease involving the pulmonary vascular circuit, is defined as an elevation in pulmonary arterial pressures and is characterized by symptoms of dyspnea, chest pain, and syncope. If left untreated, the disease carries a high mortality rate, with the most common cause of de...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/SMJ.0b013e31802f2ff1
更新日期:2007-04-01 00:00:00
abstract::Thoracic nerve root dysfunction (TNRD) manifested as abdominal pain is an infrequently reported condition. We present data on six patients who had chronic intermittent thoracoabdominal pain originating in the back. Diabetes and osteoarthritis of the spine were the chief causes of these symptoms. The electromyogram in ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198802000-00014
更新日期:1988-02-01 00:00:00
abstract::Axillary and palmar hyperhidrosis are featured prominently in the literature, but no previous studies have detailed a treatment regimen for specific excessive localized sweating of the face and scalp. In this report, a patient was treated for this condition with a combination of clonidine hydrochloride (0.3 mg to 0.4 ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2000-01-01 00:00:00
abstract::We have reported a case of benign papillary mesothelioma of the peritoneum found incidentally during surgical exploration in a patient with rectal carcinoma. Clinicians and pathologists alike may find it difficult to differentiate this uncommon lesion from metastatic tumors. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198912000-00032
更新日期:1989-12-01 00:00:00
abstract::The clinical presentations of liver abscess, hepatoma, and metastatic tumor to the liver may be quite similar, and procedures such as computerized tomography, radionuclide scanning, and ultrasonography of the liver cannot make a specific diagnosis. Therefore, we compared the clinical presentations of 38 patients seen ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198712000-00013
更新日期:1987-12-01 00:00:00
abstract:OBJECTIVES:Insurance status has the potential to play a significant role in an individual's health care by affecting the time of diagnosis and the treatment options used. Our study reviewed insurance status as a determinant of the time of a breast cancer diagnosis as well as the surgical treatment options offered. MET...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000281
更新日期:2015-05-01 00:00:00
abstract::This case report describes an accidental ingestion of a gold dental inlay prosthesis that became lodged in the appendix. A nonsurgical approach was pursued because this blunt foreign body posed a minimal perforation risk. A second opinion for an elective appendectomy was chosen by the patient until a preoperative abdo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199807000-00012
更新日期:1998-07-01 00:00:00
abstract::Gabapentin, an antiepileptic agent, is a safe and versatile medication also used in the adjunctive treatment of painful disorders. These include neuropathic pain, such as postherpetic neuralgia, diabetic neuropathy, and the pain of reflex sympathetic dystrophy. Interstitial cystitis, a painful disease entity, shares m...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract::Using a phylogenic classification of the spine, one can identify precisely the numerical location of any vertebra or disc, including vertebrae with junctional anomalies at transitional zones. Such precision permitted comparisons of myelographic reports of sites of disc disease with the actual levels of extradural defo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197909000-00017
更新日期:1979-09-01 00:00:00
abstract::We reviewed 76 cases of small cell bronchogenic carcinoma seen at the University of South Florida Medical Center. One third of the 55 patients who have subsequently died did so within one month of diagnosis. Thirty-five patients were treated with cyclophosphamide, adriamycin, vincristine, and radiation therapy includi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197805000-00013
更新日期:1978-05-01 00:00:00
abstract::In two decades there has been a sweeping metamorphosis of the antiquated conception of breast cancer as a solitary mass of questionable operability, accompanied by numerous axillary lymph nodes and probably distant metastasis. An undreamed-of recognizable preclinical stage of breast cancer has drastically changed atti...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197811000-00004
更新日期:1978-11-01 00:00:00
abstract::Seven patients with diabetes of ten to 24 years' duration and renal insufficiency were treated with fluphenazine and amitriptyline in an attempt to control severe pain in the extremities. Six patients had relief of pain within five days of initiation of therapy. One patient had no pain relief despite mood alteration. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1983-04-01 00:00:00
abstract::Acute calcareous deposits of the hand and wrist have been infrequently reported. A review of the literature and five recent cases indicate that these painful lesions will respond rapidly to immobilization and medication. Differentiation from infection is important. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198002000-00009
更新日期:1980-02-01 00:00:00
abstract:OBJECTIVES:Age-related macular degeneration (AMD) is the leading cause of blindness in the United States. Although AMD shares multiple risk factors with coronary artery disease (CAD), the association between AMD and CAD has not been established. The objective of our study was to demonstrate an association between the d...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000329
更新日期:2015-08-01 00:00:00
abstract::The Pelorus Stereotactic Surgical System is a relatively new, commercially available device that can be used to perform computed tomography (CT)-guided stereotactic brain biopsy. It has been promoted as being a relatively simple and inexpensive system that is more rapid, less cumbersome, and generally easier to use th...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199307000-00008
更新日期:1993-07-01 00:00:00
abstract::A case of Wuchereria bancrofti filariasis was recently seen in a Haitian immigrant in Charleston, SC. The Caribbean area is a known endemic focus for this organism. With the increased numbers of immigrants from that area, it is likely that other such cases will be seen in the US. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198504000-00032
更新日期:1985-04-01 00:00:00
abstract::Fluoxetine is an antidepressant drug with a unique chemical configuration which enhances serotoninergic transmission by inhibiting serotonin uptake. The chronic presence of serotonin in the synaptic cleft reduces postsynaptic receptors, a postulated explanation for its antidepressant efficacy. Comparative studies show...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:1989-08-01 00:00:00
abstract::In addition to assuring an adequate and safe blood supply, blood collection agencies are responsible for the well being of donors. Several aspects of the current blood donor experience may negatively impact donor health and require modification. Physicians need to be aware of health-related issues associated with bloo...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/SMJ.0b013e3181d3904f
更新日期:2010-04-01 00:00:00
abstract::Many factors contribute to the attainment of adult height, including genetic and environmental variables. To assess the relationship between menarcheal age and adult height, measured adult height and recalled menarcheal age were compared by regression analysis in 425 women. The overall regression equation, Height = 15...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198904000-00009
更新日期:1989-04-01 00:00:00
abstract::Using local anesthesia, we did 97 carotid endarterectomies--48 of them for acute completed stroke, stroke in evolution, or stroke associated with unstable neurologic status, and 49 for transient cerebral ischemic attack. The neurologic status of the awake patients was monitored continuously. Neurologic deterioration r...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198912000-00013
更新日期:1989-12-01 00:00:00
abstract::We have described a case of chronic pancreatitis due to stenosing papillitis relieved by sphincteroplasty and removal of pancreatic duct stones, as opposed to a major pancreatic resection. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198310000-00033
更新日期:1983-10-01 00:00:00