Abstract:
OBJECTIVES:Age-related macular degeneration (AMD) is the leading cause of blindness in the United States. Although AMD shares multiple risk factors with coronary artery disease (CAD), the association between AMD and CAD has not been established. The objective of our study was to demonstrate an association between the diagnosis of AMD and CAD and/or major cardiovascular risk factors. METHODS:We performed a retrospective chart review of >13,000 patients at the Lexington Veterans Affairs Medical Center. Patients diagnosed as having AMD served as cases, and patients diagnosed with cataract and no AMD served as controls. We examined the prevalence of CAD and associated risk factors in both groups using univariate analysis followed by multivariate analyses to examine the association between AMD and CAD after adjusting for known common risk factors. RESULTS:We identified 3950 patients with AMD and 9166 controls. Patients with AMD were on average 6 years older than controls (P < 0.001) and had a significantly higher prevalence of CAD (39% vs 34%) and hypertension (88% vs 83%) but lower incidence of diabetes mellitus and smoking. Estimated odds ratio relating CAD to AMD was 1.22 (95% confidence interval 1.13-1.32; P < 0.001). The association between CAD and AMD remained significant in multivariate analyses in older individuals (76 years and older). When we conducted a secondary analysis and matched the AMD and non-AMD groups based on age, the association between CAD and AMD remained significant (39.4% in the AMD group vs 36.6% in the non-AMD group; P = 0.011). CONCLUSIONS:These findings support the existence of an association between CAD and AMD, particularly in older adult patients in the predominantly male Veterans Affairs population. Such an association between AMD and systemic vascular disease justifies the potential coscreening for these conditions.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Thomas J,Mohammad S,Charnigo R,Baffi J,Abdel-Latif A,Ziada KMdoi
10.14423/SMJ.0000000000000329subject
Has Abstractpub_date
2015-08-01 00:00:00pages
502-6issue
8eissn
0038-4348issn
1541-8243pii
SMJ50057journal_volume
108pub_type
杂志文章abstract:BACKGROUND:We investigated the risk factors for gallstone disease in Taiwan. METHODS:We retrospectively analyzed medical records of patients receiving periodic health examination at China Medical College Hospital from January to December 2000. A detailed history, physical examination, biochemical measurements, and abd...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract::An infected echinococcal cyst of the liver was diagnosed in a 48-year-old male immigrant from Spain. After preoperative treatment with mebendazole, microscopic examination of the operative cyst contents showed no viable scoleces or brood capsules of Echinococcus. We recommend the preoperative use of mebendazole in the...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract::Ruptured ovarian artery aneurysm is rare. Of the eight cases previously reported, seven were diagnosed postpartum. Our case of a ruptured right ovarian artery aneurysm was associated with massive retroperitoneal bleeding. The probable time of rupture could be traced to the second stage of labor. This case indicates th...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199309000-00023
更新日期:1993-09-01 00:00:00
abstract::Ours is apparently the first reported pediatric case of Stomatococcus mucilaginosus bacteremia. It is the second reported case of S mucilaginosus catheter-associated infection, but the first case successfully treated without removing the central venous catheter. This unusual organism should be added to the list of opp...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199103000-00029
更新日期:1991-03-01 00:00:00
abstract::The Chronic Illness Problem Inventory (CIPI) was used to assess level of psychosocial functioning in 89 patients with sickle cell disease. The results indicated that sickle cell patients have significant psychosocial distress in the areas of employment and finances, sleeping and eating, and performance of normal daily...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198806000-00015
更新日期:1988-06-01 00:00:00
abstract:OBJECTIVES:Accurate and consistent documentation of pain management, including patient responses regarding improvement in pain scores, is essential for improving patient care. The objective of the project was to evaluate the current prescribing patterns and to review the current documentation for opioid-managed, chroni...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3182296f20
更新日期:2011-09-01 00:00:00
abstract::Seizures are common in acute exacerbations of hepatic porphyria, even though the etiology is not identified in most cases. We have reported a case of normeperidine-induced seizures in a patient with hereditary coproporphyria. Although meperidine is commonly used for pain control during acute attacks in these patients,...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199011000-00020
更新日期:1990-11-01 00:00:00
abstract:OBJECTIVES:Concerns regarding lack of privacy, poor patient understanding, and physician discomfort have led to a decline in rounding at the bedside. Our project explored patient perceptions of the implementation and value of bedside rounding. METHODS:This mixed-methods study used semi-structured qualitative interview...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000803
更新日期:2018-05-01 00:00:00
abstract::We have described a case of thrombocytopenic purpura caused by methyldopa. A methyldopa-dependent antiplatelet antibody as the mechanism of the patient's thrombopenia was suggested by a positive clot retraction inhibition test. This simple in vitro test should be done more often in suspected cases of drug-induced thro...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198203000-00036
更新日期:1982-03-01 00:00:00
abstract::Reported is the fifth known case of Addison's disease due to adrenal involvement by North American blastomycosis (Blastomyces dermatitidis infection). The fact that amphotericin B therapy precipitated an addisonian crisis suggests that patients with disseminated blastomycosis should have their adrenal function and res...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197707000-00028
更新日期:1977-07-01 00:00:00
abstract:BACKGROUND:The prevalence of smoking in the general US population has declined significantly over the past few decades. Despite this, few studies have examined changes in cigarette attributes perceived by less educated, rural, or southern populations. METHODS:A survey was administered to individuals in clinic waiting ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2002-07-01 00:00:00
abstract::High fever occurred in a 30-year-old woman five weeks after transsphenoidal hypophysectomy for a pituitary adenoma. Extensive investigation failed to reveal any evidence of infection, and the clinical findings suggested the fever to be a manifestation of steroid withdrawal. Either suboptimal dosage of corticosteroid r...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198903000-00027
更新日期:1989-03-01 00:00:00
abstract::The correct diagnosis of benign hyperthyroxinemia in this patient and his family members will spare them the unnecessary testing and treatment for thyrotoxicosis that has befallen some such patients. Results of the usual blood tests for assessment of thyroid function, such as T4, T3, and thyrotropin determinations, we...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198903000-00022
更新日期:1989-03-01 00:00:00
abstract::In a ten-year period 139 patients with epidermoid carcinoma of the esophagus were treated by palliative feeding procedures, palliative radiation therapy, radiation therapy for cure, or resection. Analysis of the results of these modes of therapy indicates that long-term palliation is best achieved when resection is th...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197606000-00016
更新日期:1976-06-01 00:00:00
abstract::The ability of Clonorchis sinensis to cause severe hepatobiliary disease is illustrated by the case we have reported, in which biliary obstruction and hepatic fibrosis resulted from the pathologic process associated with chronic clonorchiasis. Immunodiagnostic tests are currently limited, and diagnosis, as illustrated...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198707000-00030
更新日期:1987-07-01 00:00:00
abstract::As with our case, patients with rupture of the atrium may survive untreated for prolonged periods. Although three survivors have been reported after rupture of the right or left ventricle, ventricular injuries are usually fatal. With improvements in transportation methods, rapid recognition and diagnosis, and early op...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198604000-00027
更新日期:1986-04-01 00:00:00
abstract::In a retrospective review of one year's experience in the management of neck trauma, 88 cases comprising 42 gunshot wounds, 29 stab or slash injuries, and 17 injuries by blunt trauma were reviewed. Multiple injuries were noted in all groups, but a higher percentage was found in the blunt trauma series. Anesthetic mana...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197909000-00004
更新日期:1979-09-01 00:00:00
abstract::Morbid obesity and type II diabetes, common complications of Prader-Willi syndrome (PWS), are difficult to manage in the home setting. We assessed the effect of specialized group home placement on these complications in eight individuals with PWS, all of whom were obese and four of whom had type II diabetes. The group...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract::Of 239 patients with erectile dysfunction (aged 36 to 70 years) who were evaluated with dynamic infusion cavernosometry-cavernosography, 32 (13.4%) developed priapism after the procedure and were successfully managed with immediate intracorporal injection of phenylephrine. No single risk factor for the development of ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199311000-00016
更新日期:1993-11-01 00:00:00
abstract::Asthma is a chronic inflammatory disease in which the genetic predisposition to allergic disease is the strongest identifiable predisposing factor. (1) Optimal outpatient treatment of asthma includes identifying and minimizing exposure to asthma triggers, whether they Me allergens or irritants. When these triggers are...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:2002-07-01 00:00:00
abstract::Extraskeletal dedifferentiated chondrosarcomas (DC) are uncommon tumors that predominantly occur in the head and neck. Herein, we describe a case of pulmonary DC detected in a patient with systemic sclerosis and presenting with a symptomatic large pleural effusion and a pulmonary lobar consolidation on chest imaging. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181ad6236
更新日期:2009-08-01 00:00:00
abstract::Some cultural and epidemiologic factors leading to a new emphasis on self-care in chronic illness are reviewed and current applications of self-care in medicine are illustrated with examples. Emotional and behavioral aspects of self-care programs are detailed with special attention to compliance, family involvement, a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198309000-00016
更新日期:1983-09-01 00:00:00
abstract::The modern, comprehensive care of patients with hemophilia requires an awareness that complications other than those caused by acute hemorrhage can occur. The use of newer, more potent plasma concentrates has been accompanied by an increased incidence of liver disease in transfusion-requiring hemophiliacs. The progres...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198002000-00011
更新日期:1980-02-01 00:00:00
abstract::The majority of abnormalities at the foramen of Monro identified by computed tomography (CT) are colloid cysts, but a number of other diseases in this location may produce a similar CT appearance. In a series of 21 patients the radiologic findings included six colloid cysts, two neoplasms, five vascular lesions, three...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198312000-00016
更新日期:1983-12-01 00:00:00
abstract::A 37-year-old black man with presumed Pneumocystis carinii pneumonia who was treated with systemic IV pentamidine had fatal pancreatitis and massive hepatomegaly. Fatal pancreatitis can occur with no hemorrhagic changes seen at autopsy. Awareness of the relationship between pentamidine and pancreatitis should be empha...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00
abstract::The oropharyngeal function study is a videotaped radiographic examination of the oropharynx and cervical esophagus used in patients who are at major risk for aspiration because of swallowing difficulty. Preceding the radiographic evaluation, the patient is assessed clinically by a swallowing therapist who attends the ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199002000-00013
更新日期:1990-02-01 00:00:00
abstract:BACKGROUND:Screening mammography, particularly for women in their 40s, has become a confusing issue for many physicians. Recent scientific and political controversies regarding screening guidelines have added to this confusion. METHODS:Many randomized clinical trials have shown the benefits of mammographic screening f...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:
更新日期:1998-06-01 00:00:00
abstract::Liver cysts are a well-recognized feature of autosomal dominant polycystic kidney disease (ADPKD) and occur in 77% of patients more than 60 years old. Serious sequelae, however, are rare, the two most common complications being pain and cyst infections. Portal hypertension has been reported in ADPKD due to the rare pr...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199906000-00015
更新日期:1999-06-01 00:00:00
abstract::Abscess of the spleen is uncommon and potentially lethal, but until recently it was rarely diagnosed except by exploratory celiotomy or at autopsy. Now, with the advent of radionuclide scanning, ultrasonography, and selective angiography, earlier diagnosis is possible in most cases. We report a case of traumatic absce...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197905000-00019
更新日期:1979-05-01 00:00:00
abstract::A 75-year-old woman suffering from symptomatic cholelithiasis was admitted to our hospital for elective laparoscopic cholecystectomy (LC). Intraoperatively, because of severe inflammation and dense adhesions in the region of the Calot triangle and bleeding arising from the porta hepatis which obscured the operating fi...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.smj.0000242793.15923.1a
更新日期:2007-03-01 00:00:00