Euthyroid hyperthyroxinemia due to familial excess of thyroxine-binding globulin.

Abstract:

:The correct diagnosis of benign hyperthyroxinemia in this patient and his family members will spare them the unnecessary testing and treatment for thyrotoxicosis that has befallen some such patients. Results of the usual blood tests for assessment of thyroid function, such as T4, T3, and thyrotropin determinations, were not uniformly diagnostic, and were potentially misleading. An increased T4 level, a nonsuppressed TSH level, normal levels of FT4 and FT4D, and a low level of T3RU were clues that led to a request for specific measurement of serum TBG levels in multiple family members; family testing was essential for the diagnosis of euthyroid hyperthyroxinemia due to familial hepatic overproduction of TBG.

journal_name

South Med J

journal_title

Southern medical journal

authors

Tucker WS Jr

doi

10.1097/00007611-198903000-00022

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

368-71

issue

3

eissn

0038-4348

issn

1541-8243

journal_volume

82

pub_type

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