Abstract:
:Fluoxetine is an antidepressant drug with a unique chemical configuration which enhances serotoninergic transmission by inhibiting serotonin uptake. The chronic presence of serotonin in the synaptic cleft reduces postsynaptic receptors, a postulated explanation for its antidepressant efficacy. Comparative studies show that the therapeutic effectiveness of fluoxetine is equal to that of imipramine, amitriptyline, and doxepin. A 20 mg morning dose alleviates most depressions. The long half-life of one to three days for the parent compound and seven to 15 days for the active metabolite, desmethylfluoxetine, is largely unaffected by age or renal impairment. Nausea, nervousness, insomnia, and headache are the most common side effects. Therapeutic doses do not affect cardiac conduction or cause orthostasis. A primary benefit of this drug is its significant relative safety in overdoses as compared to other antidepressants.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Pary R,Tobias C,Lippmann Ssubject
Has Abstractpub_date
1989-08-01 00:00:00pages
1005-9issue
8eissn
0038-4348issn
1541-8243journal_volume
82pub_type
杂志文章,评审abstract::Between 1975 and 1978, over 200 knee arthroscopies were performed at the Emory University Hospitals; the findings were totally correct in 91%. During the same period, arthrograms were performed on 79 different patients, 39 of whom had confirming arthrotomies. The arthrograms were totally correct in 38%. Fifteen totall...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198111000-00009
更新日期:1981-11-01 00:00:00
abstract:BACKGROUND:The decision to place a percutaneous feeding tube (PFT) in patients who are at the end of life is multidimensional and often complicated. We assessed the effect of physician education and counseling for patients and their surrogates on inpatient nonsurgical (endoscopic and radiologic) PFT placement rates, in...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181c9800f
更新日期:2010-02-01 00:00:00
abstract::Many psychiatric patients experience pharmaceutical intolerances, and some of them do not derive optimal efficacy from their pharmacotherapies. Clinical problems such as these may result in prolonged dysfunction, adverse consequences, and repeated changes in medication treatment regimens. Pharmacogenomics is a laborat...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000534
更新日期:2016-10-01 00:00:00
abstract::Two cases are reviewed which presented findings strongly suggesting congenital synostosis between the third metatarsal and third cuneiform bones. Supplementary x-ray films proved these joints to be present and intact. This point, though well known to skeletal radiologists, is worthy of emphasis to nonskeletal radiolog...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::A case of an extramedullary plasmacytoma (EMP), which presented with a solitary pelvic tumor, is reported. Complete tumor resection was performed, followed by radiation therapy. Our experience demonstrates a satisfactory short-term oncological outcome. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181e6d082
更新日期:2010-08-01 00:00:00
abstract::Clotrimazole is a new antifungal agent which is effective topically in dermatophytosis, cutaneous candidiasis, and tinea vesicolor. The authors performed a controlled double-blind clinical trial comparing topical clotrimazole with its vehicle in the treatment of 66 patients with dermatophytic infections of the skin of...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:10.1097/00007611-197701000-00021
更新日期:1977-01-01 00:00:00
abstract::A 37-year-old black man with presumed Pneumocystis carinii pneumonia who was treated with systemic IV pentamidine had fatal pancreatitis and massive hepatomegaly. Fatal pancreatitis can occur with no hemorrhagic changes seen at autopsy. Awareness of the relationship between pentamidine and pancreatitis should be empha...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1991-06-01 00:00:00
abstract::Solitary abscesses of the spleen may occur as a consequence of septicemia from various septic foci, particularly intra-abdominal sites. A variety of causative organisms, including the clostridia, have been isolated. We have described a patient with multiple myeloma who had a solitary splenic abscess due to Clostridium...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198710000-00029
更新日期:1987-10-01 00:00:00
abstract::Carcinoma of the fallopian tube is the least common of the gynecologic malignancies. Because of its rarity and the absence of typical symptoms, preoperative diagnosis is seldom made. Patient as well as physician delay in diagnosis is often considerable. There are no reliable laboratory aids available to enhance the di...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197509000-00021
更新日期:1975-09-01 00:00:00
abstract::Phenytoin has traditionally been used for both prophylaxis and acute treatment of alcohol withdrawal seizures. With the exception of a well defined subgroup of withdrawing patients, this may not be appropriate. Chronic anticonvulsant therapy is not indicated without evidence of another underlying seizure diathesis. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197809000-00015
更新日期:1978-09-01 00:00:00
abstract::While fish consumption is considered a component of a heart-healthy diet, many illnesses have been associated with eating contaminated fish. The authors describe two cases of muscle weakness and rhabdomyolysis that occurred after eating salmon. Cases of rhabdomyolysis and muscle weakness after consumption of fresh wat...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181583673
更新日期:2007-11-01 00:00:00
abstract::In a patient with an asymptomatic left upper lobe pulmonary arteriovenous fistula, preoperative chest roentgenograms simulated bronchogenic carcinoma, but no overt feeding vessel was demonstrated. Intraoperatively no lesion could be palpated. Postoperative evaluation revealed a pulmonary arteriovenous fistula. This en...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198307000-00017
更新日期:1983-07-01 00:00:00
abstract::An 80-year-old man had acute pancreatitis during the fourth week of antibiotic therapy for enterococcal endocarditis and 12 days after initiation of ketoprofen therapy for osteoarthritis of the hip. Pancreatitis resolved after discontinuance of ketoprofen therapy and while continuing antibiotic therapy for endocarditi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199204000-00023
更新日期:1992-04-01 00:00:00
abstract::A case report and review of the literature are reported concerning the relationship of intracardiac thrombosis and antiphospholipid antibody syndromes. Nine cases are identified, divided into three categories: three patients had antiphospholipid syndrome associated with systemic lupus erythematosus, three had primary ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199409000-00014
更新日期:1994-09-01 00:00:00
abstract::I describe the case of a 25-year-old man who, after a scuba dive, had ocular barotrauma caused by mask squeeze. As in most cases, the condition occurred because the patient failed to exhale into the mask during descent to equalize the pressure within the mask. Although alarming in appearance, the condition is generall...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199407000-00015
更新日期:1994-07-01 00:00:00
abstract::This report describes a 42-year-old man with Brugada syndrome (BRS) mimicking acute coronary syndrome. Chest pain, near-syncope, and electrocardiographic changes were thought initially to be due to ischemia. Cardiac catheterization was performed. The coronary arteries and left ventricular function were normal. Careful...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000168135.26545.a6
更新日期:2005-08-01 00:00:00
abstract::Sickle cell trait is present in about 8% of black Americans, and clinically significant sickling disorders are common in this population. These disorders can be accurately defined by combinations of quantitative hemoglobin electrophoresis at alkaline pH, citrate agar electrophoresis, solubility tests for sickle hemogl...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197804000-00021
更新日期:1978-04-01 00:00:00
abstract::To understand fully a physician's role in society, and to deal successfully with the current sense of crisis, the medical profession must evolve a world-view that appropriately relates a physician to the patient, to the practice environment, to the base of knowledge, and to the physician's own sense of self. Such a wo...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198812000-00022
更新日期:1988-12-01 00:00:00
abstract::The ability of Clonorchis sinensis to cause severe hepatobiliary disease is illustrated by the case we have reported, in which biliary obstruction and hepatic fibrosis resulted from the pathologic process associated with chronic clonorchiasis. Immunodiagnostic tests are currently limited, and diagnosis, as illustrated...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198707000-00030
更新日期:1987-07-01 00:00:00
abstract:OBJECTIVES:Manifestations of gastroparesis are heterogeneous and clinical complications are poorly defined. Misconceptions of gastroparesis may be common. The objective was to determine physicians' perception of gastroparesis and identify areas that need further research and education. METHODS:A physician survey was p...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e318215fa5a
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVES:To explore temporal trends and geographic variations in mortality from prescription opioids from 1999 to 2016. METHODS:Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research Multiple Cause of Death files were used to calculate age-adjusted rates and 95% confidence int...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000001074
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:To determine the comparative impact of the standard Parents as Teachers (PAT) to the nutrition and physical activity enhanced version (PATE) of the perinatal educational curriculum on compliance with infant feeding recommendations and changes in maternal infant feeding knowledge and beliefs. METHODS:Women a...
journal_title:Southern medical journal
pub_type: 杂志文章,随机对照试验
doi:10.14423/SMJ.0000000000001024
更新日期:2019-10-01 00:00:00
abstract::A retrospective review of five patients with Barrett's esophagus revealed three with an associated active duodenal ulcer. Two patients also had adrenocarcinoma of the esophagus. Any patient with prolonged gastroesophageal reflux should have careful radiologic and endoscopic evaluation of the entire upper gastrointesti...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198103000-00012
更新日期:1981-03-01 00:00:00
abstract::A 66-year-old white male presented with jaundice, pruritus, and a 30-pound weight loss over two months. Physical examination revealed scleral icterus. Laboratory evaluation revealed ALT 161 U/L, AST 290 U/L, alkaline phosphatase 2004 U/L, GGT 2,552 U/L, total bilirubin 10.2 mg/dL, and a carbohydrate antigen 19-9 (CA 1...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.smj.0000202695.97123.2b
更新日期:2006-03-01 00:00:00
abstract::Mesenteric occlusion is a rare and usually fatal complication of rheumatoid arthritis (RA). We report a patient with RA who had an acute condition of the abdomen, with clinical evidence of perforated bowel confirmed by histologic study. The successful result in this case is attributed to early surgical intervention. A...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198007000-00034
更新日期:1980-07-01 00:00:00
abstract:OBJECTIVES:Accurate and consistent documentation of pain management, including patient responses regarding improvement in pain scores, is essential for improving patient care. The objective of the project was to evaluate the current prescribing patterns and to review the current documentation for opioid-managed, chroni...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3182296f20
更新日期:2011-09-01 00:00:00
abstract::We have described a patient with vaccinia necrosum after smallpox vaccination for persistent herpes labialis. The patient eventually recovered after surgical resection of the lesion and multiple courses of vaccinia immune globulin and methisazone. This report emphasizes the needless risks of vaccinating patients with ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198103000-00044
更新日期:1981-03-01 00:00:00
abstract::Chordomas are tumors originating from remnants of the notochord, most commonly found in the cranial and caudal regions. This is a report of the seventh intrathoracic chordoma in the world literature and the second to be reported in a woman. Histologically the physalipherous (blister-bearing) cell is characteristic of ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197501000-00029
更新日期:1975-01-01 00:00:00
abstract::Ruptured ovarian artery aneurysm is rare. Of the eight cases previously reported, seven were diagnosed postpartum. Our case of a ruptured right ovarian artery aneurysm was associated with massive retroperitoneal bleeding. The probable time of rupture could be traced to the second stage of labor. This case indicates th...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199309000-00023
更新日期:1993-09-01 00:00:00
abstract::Arsenic poisonings occur in Mississippi despite public education campaigns to prevent poisonings in the home. We reviewed 44 Mississippi cases of arsenic exposures occurring from January 1986 to May 1990. We compared the epidemiologic differences between unintentional and intentional poisonings. Cases were found and c...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199104000-00012
更新日期:1991-04-01 00:00:00