Abstract:
:Pulmonary arterial hypertension (PAH), a rare disease involving the pulmonary vascular circuit, is defined as an elevation in pulmonary arterial pressures and is characterized by symptoms of dyspnea, chest pain, and syncope. If left untreated, the disease carries a high mortality rate, with the most common cause of death being decompensated right heart failure. Over the past 5 years, there have been significant advances in this field in regards to understanding the pathogenesis, diagnosis, and classification of PAH. The availability of newer drugs has resulted in a radical change in the management of this disease with significant improvement in both quality of life and mortality. Ongoing research promises to lead to a more comprehensive understanding of the genetics, etiology, and pathogenesis of pulmonary arterial hypertension, which may ultimately translate into more effective therapeutic options.
journal_name
South Med Jjournal_title
Southern medical journalauthors
LaRaia AV,Waxman ABdoi
10.1097/SMJ.0b013e31802f2ff1subject
Has Abstractpub_date
2007-04-01 00:00:00pages
393-9issue
4eissn
0038-4348issn
1541-8243journal_volume
100pub_type
杂志文章,评审abstract::Disorders of the foregut are an increasingly common cause of symptoms in Western populations. This review summarizes recent advances in the understanding and treatment of gastroesophageal reflux disease, dyspepsia and celiac disease. ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.smj.0000242808.91797.3d
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:Cystic fibrosis (CF) is associated with vitamin D deficiency, which can lead to adverse effects including recurrent pulmonary infections and osteoporosis. We longitudinally investigated calcifediol or 25-hydroxyvitamin D (25(OH)D) levels for our pediatric patients with CF based on the time of year as well as...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000254
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVES:Program directors have noted that first-year residents struggle with many of the patient care responsibilities they assume as they enter the US graduate medical education system. A national description of medical students' patient care experience in advance of graduation has not been published. We sought to ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000738
更新日期:2017-12-01 00:00:00
abstract::Our purpose was to determine the discovery method and stage of newly discovered breast cancers at two different medical centers. To do this, we conducted a retrospective chart review at our urban and suburban teaching hospitals during 1991 through 1992 and 1992, respectively. Only 29 (26%) of 112 cancers at our urban ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199511000-00005
更新日期:1995-11-01 00:00:00
abstract::Lyme disease, now the most common tick-borne illness in the United States, has recently received much media attention, due in part to its potentially serious sequelae in untreated patients. Because a rare patient with late illness may lack antibodies to the etiologic agent, Borrelia burgdorferi, physicians may be temp...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199110000-00024
更新日期:1991-10-01 00:00:00
abstract::We report four cases of group A streptococcal vulvovaginitis in prepubertal children. All cases were acute in onset. This illness presents with nonspecific signs and symptoms of labial inflammation. In a suburban community, streptococcal vulvovaginitis in prepubescent girls may be more common then genital infections d...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198204000-00017
更新日期:1982-04-01 00:00:00
abstract::Although alpha 1-antitrypsin deficiency has been associated with obstructive lung disease in individuals possessing a homozygous phenotype (PiZZ), this association has not been as clearly documented in heterozygous individuals (PiMZ, PiMS, and PiSZ phenotypes). Information regarding the heterozygous adolescent populat...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199610000-00018
更新日期:1996-10-01 00:00:00
abstract::Recent research suggests that vitamin D may play a role in cardiovascular (CV) health. Although its exact role is still debated and is a matter of controversy, vitamin D deficiency has been linked to increased prevalence of CV risk factors and events. Factors that predispose persons with congestive heart failure (CHF)...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/SMJ.0b013e318213cf6b
更新日期:2011-05-01 00:00:00
abstract::Extramural programs may be evaluated in terms of effectiveness in achieving their particular goals. The components of structure, process, and outcome are examined as related sets of program elements. Goals influence appropriate structure in organization, facilities, and manpower. Structure in turn influences process o...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197906000-00027
更新日期:1979-06-01 00:00:00
abstract::We have reported the case of a 30-year-old woman with Cushing's disease who died of massive pulmonary thromboembolism 5 weeks after successful transsphenoidal hypophysectomy. Glucocorticoid excess appears to cause a hypercoagulable state, and consideration of this thromboembolic propensity and its potential duration a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199008000-00026
更新日期:1990-08-01 00:00:00
abstract::A patient with thioridazine-hydrochloride-associated agranulocytosis is described and eight previously reported cases are reviewed. This complication is most likely due to a direct toxic effect on the bone marrow. As in our case, markers for an immunologically mediated mechanism have not been found. Thioridazine-hydro...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197701000-00051
更新日期:1977-01-01 00:00:00
abstract::Food safety is an increasing concern to Americans. Recent recalls of peanuts and pistachios, and Food and Drug Administration (FDA) warnings to pregnant women to avoid eating fish have increased government oversight of food processing and handling. Consumers can play an important role in alerting their healthcare prov...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181be29af
更新日期:2010-04-01 00:00:00
abstract::A 46-year-old woman had features of acute pulmonary edema soon after taking hydrochlorothiazide (HCTZ) for the first time. Although 31 cases of HCTZ-induced pulmonary edema have been reported in the world literature since it was first described in 1968, little is known about this clinical entity. Because its presence ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199911000-00013
更新日期:1999-11-01 00:00:00
abstract::Chronic pain can be treated by combining hypnosis with brief psychotherapy. Hypnosis alone, though useful for acute pain, is seldom effective in relieving chronic pain because it does not address the significant psychologic components in the patient's illness. Treatment using self-hypnosis in conjunction with brief ps...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198303000-00013
更新日期:1983-03-01 00:00:00
abstract::Many health care providers practicing near the border between the United States and Mexico have serious concerns about their patients' using medications obtained in Mexico. Despite these concerns, the extent of this problem is not known. A survey administered in a publicly funded rural clinic and an urban private prac...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199003000-00003
更新日期:1990-03-01 00:00:00
abstract::The diagnosis of sarcoidosis is best established when there is evidence of granulomatous involvement in two or more organs. Three patients with unusual cutaneous manifestations of sarcoidosis, including palmar and follicular lesions, nonscarring alopecia, and widespread plaque or erythrodermic sarcoidosis, are reporte...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197706000-00009
更新日期:1977-06-01 00:00:00
abstract::A hallmark of the clinical syndrome of thrombotic thrombocytopenic purpura (TTP) is evidence of microangiopathic hemolytic anemia. The presence of schistocytes on the peripheral blood smear, elevated plasma lactic dehydrogenase, and decreased haptoglobin concentration are used as evidence of microangiopathic hemolytic...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000136231.83564.F6
更新日期:2005-03-01 00:00:00
abstract::Even though epidural analgesia is effective and has advantages over conventional postoperative analgesia, it is also labor intensive, requiring 24-hour supervision by an anesthesiologist. In an effort to decrease the manpower requirements, some hospitals allow the nursing staff to administer epidural narcotics to adul...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199204000-00012
更新日期:1992-04-01 00:00:00
abstract::We present the first two known cases of infantile botulism in Oklahoma. The first case was due to type B toxin; the second was due to type A toxin. Both cases demonstrate most of the classic features of what now appears to be the most common form of botulism. Infantile botulism is an underrecognized but reversible cau...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198804000-00012
更新日期:1988-04-01 00:00:00
abstract::All cases of surgically proven and cured primary hyperparathyroidism, over a five-year period, were reviewed for the presence of hypertension, renal and/or prerenal azotemia, nephrolithiasis, nephrocalcinosis, and patient symptom status. In this group of 23 patients, the prevalence of hypertension was greater than 78%...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198211000-00018
更新日期:1982-11-01 00:00:00
abstract::Vesicoureteral reflux occurs in approximately 50% of duplex systems that undergo evaluation and most commonly involves the lower renal segment ureter. The therapeutic approach can be tailored for each case after careful evaluation of the anatomic and functional status of each renal unit. If reparative srugery is indic...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197611000-00017
更新日期:1976-11-01 00:00:00
abstract::Interruption of the inferior vena cava by the transvenous placement of a filter or umbrella effectively prevents pulmonary embolism by acting primarily as a physical barrier to emboli. Such a device will be effective only if the site of thrombosis is distal to the planned placement site. We have presented two cases in...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198906000-00025
更新日期:1989-06-01 00:00:00
abstract::Diagnostic peritoneal lavage (DPL) is an established procedure in evaluation of trauma victims but is less well established for use in patients suspected of having acute intra-abdominal disease. Twenty-six seriously ill patients at our institution who had DPL for acute intra-abdominal disease form the basis of this re...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199004000-00015
更新日期:1990-04-01 00:00:00
abstract::Herpes zoster and disseminated herpes zoster, or varicella (V-Z), continue to be dreaded complications of patients with immunosuppression. Currently, there is no available therapy for V-Z, except for general supportive measures. Seven cases of V-Z are presented, showing the results of cytosine arabinoside administrati...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197808000-00011
更新日期:1978-08-01 00:00:00
abstract::Each year an estimated 1.3 million Americans suffer eye injuries. There is little information in the literature regarding the prevalence, demographic characteristics, and prognosis of these patients. The Eye Injury Registry of Alabama (EIRA) serves as the first and only statewide system of its kind for the collection ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198707000-00004
更新日期:1987-07-01 00:00:00
abstract::Computed tomography is widely used to diagnose acute pancreatitis. Iodinated contrast medium lengthens the duration of pancreatitis and may increase the incidence of local or systemic complications. Total parenteral nutrition including IV lipid emulsion plays an important role in the management of patients with pancre...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000047667.00302.CD
更新日期:2003-01-01 00:00:00
abstract::Takotsubo (stress induced) cardiomyopathy is also known as broken heart syndrome or transient left ventricular apical ballooning syndrome. The clinical presentation, which mimics acute myocardial infarction, is preceded by intense emotional or physical stress. Recurrence of apical ballooning syndrome seems to be rare....
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181e631ce
更新日期:2010-08-01 00:00:00
abstract::We reviewed the first 100 consecutive patients treated with extracorporeal shock wave lithotripsy (ESWL) at one institution. A total of 115 treatments were delivered to 58 men and 42 women. Patients with calculi of various sizes were treated and compared for (1) length of hospitalization, (2) ancillary procedures, (3)...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198801000-00010
更新日期:1988-01-01 00:00:00
abstract::Liver amyloidosis is very rare but is relatively common within the group of amyloid diseases. Jaundice seldom accompanies this condition. Since the results of liver tests are often abnormal, liver amyloidosis cannot be diagnosed by symptoms alone. Diagnosis is provided only by liver or rectal biopsy. We have described...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197907000-00041
更新日期:1979-07-01 00:00:00
abstract::Nodular fasciitis is a benign proliferation of fibroblasts and myofibroblasts in the subcutaneous tissues. The lesions are generally small and solitary, arising commonly in the upper extremities of adults and in the head and neck region of infants and children. A history of trauma may precede these reactive lesions, b...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-199408000-00020
更新日期:1994-08-01 00:00:00