Simple method to predict digoxin serum concentration.

Abstract:

:The predictability of a method of determining serum digoxin concentration was assessed in a retrospective study of 35 hospitalized patients taking digoxin orally for maintenance therapy. Simple pharmacokinetic expressions were used to estimate digoxin concentration. Clinically, the mean measured digoxin concentration (1.35 ng/ml) was in close agreement with the mean predicted value (1.36 ng/ml). There was also a strong statistical correlation between measured and predicted values (r = .82). The predictability of serum digoxin concentration was statistically equivalent in men and women. Our results indicate that a reasonably accurate prediction of digoxin concentration is possible using simple mathematical formulas that require only routine clinical data.

journal_name

South Med J

journal_title

Southern medical journal

authors

Shearer SW,Sawyer WT,Petteway SB Jr

doi

10.1097/00007611-198403000-00016

subject

Has Abstract

pub_date

1984-03-01 00:00:00

pages

332-5

issue

3

eissn

0038-4348

issn

1541-8243

journal_volume

77

pub_type

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