Abstract:
BACKGROUND:Oxybutynin is a tertiary amine and has chemical similarities like protamine sulfate. Protamine sulfate's effect on bacterial viability has been shown in some studies; however, there is scanty data regarding the effect of oxybutynin on bacterial viability. Accordingly, the aim of the present study was to investigate the effect of oxybutynin on bacterial viability. METHODS:Twenty of Staphylococcus epidermidis (S. epidermidis) strains were isolated from patients who had catheter-associated urinary tract infection. These strains were exposed to 5 different concentrations of oxybutynin in tryptic soy broth (TSB) media (max: 5 mg/mL, min: 0.05 mg/mL). Quantitative growth patterns were measured by spectrophotometer. Under the same media conditions, biofilm production of individual strains was measured by Deighton's micromethod at the end of the 6-hour incubation period. RESULTS:After the incubation period, weak and strong slime-producing bacteria groups were obtained and both groups' slime productions were extensively low at 5 mg/mL concentration of oxybutynin. Slime production of S. epidermidis was inversely correlated with oxybutynin concentrations. CONCLUSION:Although there was a dose-dependent reduction of biofilm production, there seemed to be no bactericidal effect of oxybutynin on S. epidermidis.
journal_name
South Med Jjournal_title
Southern medical journalauthors
Gedik A,Ersay A,Atmaca S,Sener Adoi
10.1097/01.smj.0000305885.23903.71subject
Has Abstractpub_date
2008-03-01 00:00:00pages
236-9issue
3eissn
0038-4348issn
1541-8243pii
00007611-200803000-00013journal_volume
101pub_type
杂志文章abstract::Cronkhite-Canada syndrome is a rare, noninherited gastrointestinal polyposis syndrome associated with characteristic ectodermal abnormalities. This report describes a 60-year-old female who was diagnosed with Cronkhite-Canada syndrome with hypothyroidism after presenting with chronic diarrhea, alopecia, intermittent a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/01.SMJ.0000157528.71614.C4
更新日期:2005-05-01 00:00:00
abstract::The demented patient requires medical and often psychiatric supervision, but the caregiver is often neglected. This article identifies special issues for caregivers that may need attention from the demented patient's physician. The physician's attention can benefit both the patient and the caregiver and save the physi...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1993-09-01 00:00:00
abstract::Forty-four patients with metastatic brain neoplasms received glycerol instead of corticosteroids during periods of brain irradiation. Headache, nausea, and vomiting were controlled in more than 90% of symptomatic patients, while paralysis, confusion, and papilledema improved in 55% to 80%. Patients with minimal or no ...
journal_title:Southern medical journal
pub_type: 临床试验,杂志文章
doi:
更新日期:1980-09-01 00:00:00
abstract::Hypothyroidism in the elderly may be associated with nonspecific symptoms. To determine the prevalence of undiagnosed hypothyroidism in residents of a skilled nursing facility, we screened 434 male and 137 female residents, aged 60 years or older, for thyroid dysfunction. Overt hypothyroidism was found in three men an...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199011000-00006
更新日期:1990-11-01 00:00:00
abstract::Cirrhosis affects millions of people around the world and is associated with increased morbidity and mortality. Spontaneous bacterial peritonitis (SBP) is a common complication of liver disease with cirrhosis and accounts for up to 30% of infections in patients with cirrhosis. Patients with a history of SBP and those ...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.14423/SMJ.0000000000000887
更新日期:2018-11-01 00:00:00
abstract::Cobalamin (vitamin B12) deficiency warrants appropriate evaluation because cobalamin is necessary in certain biochemical functions. R-binder deficiency, which causes low cobalamin levels, is a rare and benign pseudodeficiency. If not further evaluated by determining levels of methylmalonic acid and homocysteine, howev...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:2002-09-01 00:00:00
abstract::Ovarian vein thrombophlebitis is often misdiagnosed because of vague symptoms leading to unnecessary surgery, morbidity, and mortality. CT findings in such a case are very useful in making a definite diagnosis of ovarian vein thrombophlebitis. We consider CT the preferred method for evaluating pain in the right lower ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198911000-00022
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVES:Although we know much about work-related physician burnout and the subsequent negative effects, we do not fully understand work-related physician wellness. Likewise, the relation of wellness and burnout to physician happiness is unclear. The purpose of this study was to examine how physician burnout and well...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000437
更新日期:2016-04-01 00:00:00
abstract::To determine the prevalence of frequently occurring neurologic disorders in a biracial population, a survey of households and chronic care institutions was carried out for all residents of Copiah County, Mississippi. Along with a complete census, interviews were held using extensive questions about diagnoses, signs, a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198703000-00016
更新日期:1987-03-01 00:00:00
abstract::We prospectively studied preoperative and postoperative grip and pinch strength in 21 patients having 30 consecutive median nerve decompressions for carpal tunnel syndrome. All procedures were done by one surgeon. Each hand operated on served as its own control and was studied by the same therapist preoperatively and ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199209000-00009
更新日期:1992-09-01 00:00:00
abstract::This study investigated the efficacy of perioperative antibiotics in preventing bacteremic infection of vascular suture lines, Dacron grafts, and bovine heterografts. One hundred forty-nine dogs had either segmental excision of the abdominal aorta with primary repair, Dacron prosthesis, or bovine heterograft placement...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197710001-00019
更新日期:1977-10-01 00:00:00
abstract::Agenesis of the gallbladder is a rare anomaly believed to be an organogenetic failure. This is the third instance of familial agenesis of the gallbladder reported in the literature. The diagnosis of agenesis of the gallbladder can only be made during exploratory celiotomy and must be confirmed by an intraoperative nee...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197704000-00041
更新日期:1977-04-01 00:00:00
abstract::A poorly understood significant drug-drug interaction compounded by ineffective communication among providers at times of care transition most likely contributed to multiple thromboembolic events in an 81-year-old patient. Increased awareness of drug interactions with direct oral anticoagulants (DOACs), as well as imp...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000926
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To perform a needs assessment to determine the extent to which hospitalist providers recognize and intervene upon obese patients in the hospital setting. METHODS:A chart review was performed for patients admitted to the hospitalist service at Johns Hopkins Bayview Medical Center between September 1 and Octob...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e3181dfd715
更新日期:2010-06-01 00:00:00
abstract::This article reviews the epidemiology of weight gain and diabetes mellitus in general and in patients with severe mental illness in particular. Body mass index is defined, and possible predictors for weight gain in patients receiving antipsychotic medications are also enumerated. Information on risk of association wit...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/01.smj.0000167621.49292.11
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:Pneumonia is a leading infectious cause of morbidity and mortality in the United States. The Infectious Disease Society of America (IDSA) and American Thoracic Society (ATS) have published treatment guidelines for community-acquired pneumonia (CAP) based upon the site of acquisition and specific pathogen ris...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e318287fe71
更新日期:2013-03-01 00:00:00
abstract::Severe lactic acidosis is often associated with poor prognosis. Recognition and correction of the underlying process is the major step in the treatment of this serious condition. Intravenous administration of sodium bicarbonate has been the mainstay in the treatment of lactic acidosis. Aggressive use of this therapeut...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198107000-00018
更新日期:1981-07-01 00:00:00
abstract:OBJECTIVES:To determine the comparative impact of the standard Parents as Teachers (PAT) to the nutrition and physical activity enhanced version (PATE) of the perinatal educational curriculum on compliance with infant feeding recommendations and changes in maternal infant feeding knowledge and beliefs. METHODS:Women a...
journal_title:Southern medical journal
pub_type: 杂志文章,随机对照试验
doi:10.14423/SMJ.0000000000001024
更新日期:2019-10-01 00:00:00
abstract::Ours is apparently the first reported pediatric case of Stomatococcus mucilaginosus bacteremia. It is the second reported case of S mucilaginosus catheter-associated infection, but the first case successfully treated without removing the central venous catheter. This unusual organism should be added to the list of opp...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199103000-00029
更新日期:1991-03-01 00:00:00
abstract::Tramadol (Ultram) is a new analgesic agent with a dual mechanism of action that includes weak agonistic effects at the mu-opioid receptor as well as inhibition of neurotransmitter (serotonin, norepinephrine) re-uptake. Although it has proven to be a safe and effective agent for the control of pain, adverse effects can...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199708000-00010
更新日期:1997-08-01 00:00:00
abstract::We evaluated the medical history, physical examination, and laboratory tests done on 245 patients with laparoscopically proven ectopic pregnancies. The absence of abdominal pain was the only clinically useful negative predictive value (91%) regarding tubal rupture. Although mean levels of serum human chorionic gonadot...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199112000-00014
更新日期:1991-12-01 00:00:00
abstract::The aim of this project was to review the course of infants referred for consideration of extracorporeal membrane oxygenation (ECMO) to identify maximal ventilator settings that, when exceeded, did not provide clinical benefit to the patient. These settings might then be used in defining failure of conventional mechan...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199706000-00009
更新日期:1997-06-01 00:00:00
abstract::A variant of hereditary hemorrhagic telangiectasia may be gastrointestinal bleeding with no other classical symptoms. This case demonstrates the effectiveness of surgical resection as treatment of duodenal bleeding from telangiectatic lesions. ...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-198703000-00024
更新日期:1987-03-01 00:00:00
abstract::Human monocytic ehrlichiosis (HME) is a tick-borne disease transmitted during the summer months in the mid-Atlantic, southeastern and south-central United States. A large proportion of patients presenting with ehrlichiosis must be hospitalized because of the severity of their presenting signs, symptoms and lab abnorma...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/SMJ.0b013e31804aa1ad
更新日期:2007-08-01 00:00:00
abstract::Inhalation abuse of volatile solvents, previously known generically as "glue sniffing," is typically pursued by adolescents. A wide range of legal, easily obtained products containing volatile substances are available for abuse. We report two illustrative cases of fatal volatile substance abuse: gasoline sniffing in a...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:
更新日期:1996-09-01 00:00:00
abstract:OBJECTIVES:Osteopenia is considerably more common than osteoporosis and accounts for most of the fracture burden in women older than 50 years. It is uncertain when to initiate treatment in osteopenia. We sought to determine in women with osteopenia what effect transitioning to lower categories had on subsequent fractur...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.14423/SMJ.0000000000000410
更新日期:2016-02-01 00:00:00
abstract::Thirty-two cases of gonococcal arthritis in pregnant women admitted to Jackson Memorial Hospital between 1962 and 1971 are reviewed. Our specific aim is to reinforce awareness of this serious complication in pregnancy. The incidence of gonococcal arthritis is higher in women, but more significantly, it appears that th...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197511000-00004
更新日期:1975-11-01 00:00:00
abstract::Endocrine metabolic emergencies are common clinical entities seen by most health care professionals in acute care medicine. Except for cardiopulmonary arrest, few situations require such rapid institution of immediate drug therapy to reverse life-threatening metabolic imbalances. To safely guide patients through these...
journal_title:Southern medical journal
pub_type: 杂志文章,评审
doi:10.1097/00007611-198402000-00021
更新日期:1984-02-01 00:00:00
abstract::This case report describes an accidental ingestion of a gold dental inlay prosthesis that became lodged in the appendix. A nonsurgical approach was pursued because this blunt foreign body posed a minimal perforation risk. A second opinion for an elective appendectomy was chosen by the patient until a preoperative abdo...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-199807000-00012
更新日期:1998-07-01 00:00:00
abstract::Malacoplakia is a granulomatous disease of unknown cause often associated with a coliform urinary infection. It is occasionally a self-limiting disease with diverse clinical presentations and roentgenographic appearances. The importance of a differential diagnosis which considers malignancy is emphasized. A rare insta...
journal_title:Southern medical journal
pub_type: 杂志文章
doi:10.1097/00007611-197703000-00029
更新日期:1977-03-01 00:00:00