Abstract:
BACKGROUND:In an attempt to identify prognostic factors in carcinoma of the hepatic duct confluence, the value of tumor DNA content was studied in 58 patients with this type of malignancy. METHODS:Of 58 patients (ages 26 to 74 years) surgically treated for carcinoma of the hepatic duct confluence, tumor DNA content was assessed in relationship to clinical-pathologic characteristics and patient survival. Thirty-three patients underwent additive radiotherapy. Nuclear DNA content was analyzed by flow cytometry. RESULTS:Resection was radical in only three patients with negative surgical resection margins and dissection (cleavage) margins. Twenty-eight patients (48%) had diploid tumors, and 30 patients (52%) had aneuploid tumors. No significant correlation was found between tumor DNA ploidy, degree of tumor differentiation, lymph node status, and hepatic infiltration. Aneuploid tumors were significantly associated with neural invasion. The median overall survival was 18 months. The survival period of patients with diploid tumors was significantly (p < 0.0003) longer than the survival period of those with aneuploid tumors (median survival, 26 months and 11 months, respectively). Additive radiotherapy improved survival significantly only in patients with aneuploid tumors. When tested by univariate survival analysis, DNA ploidy, additive radiotherapy, and the state of the surgical resection margins were significant prognostic factors. With multivariate survival analysis, only DNA ploidy, age, hepatic infiltration, and lymph node status were significantly related to prognosis. CONCLUSIONS:This survival analysis shows that DNA ploidy is a powerful prognostic determinant of carcinoma of the hepatic duct confluence.
journal_name
Surgeryjournal_title
Surgeryauthors
Sato Y,van Gulik TM,Bosma A,Lygidakis NJ,Koyama K,van der Heyde MNsubject
Has Abstractpub_date
1994-04-01 00:00:00pages
488-94issue
4eissn
0039-6060issn
1532-7361journal_volume
115pub_type
杂志文章相关文献
SURGERY文献大全abstract::Dr McCarthy is a fellow in cardiothoracic surgery at the University of Washington. During his general surgery training at Northwestern University, he completed a research fellowship in surgical innovation and obtained masters' degrees with a focus on health enterprise management, entrepreneurship, and innovation. ...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.08.035
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Resumption of elective surgery during the current coronavirus disease 2019 pandemic crisis has been debated widely and largely discouraged. The aim of this prospective cohort study was to assess the feasibility of resuming elective operations during the current and possible future peaks of this coronavirus d...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2020.07.003
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:We attempted to assess liver ischemia/reperfusion injury under a mild decrease in core liver temperature of 10 degrees C by in situ hypothermic perfusion during ischemia. METHODS:Liver ischemia was induced in pigs by total hepatic vascular exclusion with concomitant in situ perfusion with hypothermic (4 degr...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(03)00125-9
更新日期:2003-11-01 00:00:00
abstract::Of 3,941 patients who underwent varicose vein surgery from 1968 through 1978, 163 had superficial thrombophlebitis, a common complication of varicose veins. Superficial thrombophlebitis was more frequently found in the older age groups. The incidence of occurrence (three women to one man) was identical to that of the ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1981-07-01 00:00:00
abstract::From 1951 through 1975, 72 patients with congenital intrinsic duodenal obstruction were seen at the Childrens Hospital of Los Angeles. The survival rate was 55% during the first 15 years of the study, but this has increased to 88% during the last 10 years. Factors important to this increased survival rate include: ear...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1977-11-01 00:00:00
abstract:BACKGROUND:Data are inconsistent regarding the effects of a wide surgical margin for intrahepatic cholangiocarcinoma on recurrence-free survival and overall survival. This study was performed to investigate the effect of surgical margin width in patients undergoing R0 resection for intrahepatic cholangiocarcinoma, usin...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2019.12.009
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:Resection for hepatocellular carcinoma in patients with cirrhosis and impaired liver function is usually unjustified because of higher surgical risks and poorer long-term prognosis. METHODS:A retrospective comparison of the background and resectional results of patients with cirrhosis and hepatocellular car...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80238-8
更新日期:1996-07-01 00:00:00
abstract::Local low-dose streptokinase infusion (5000 to 6000 IU/hr) as compared to systemic streptokinase infusion (loading dose 250,000 IU/hr, maintenance dose 100,000 IU/hr) successfully relieved a total thrombotic abdominal aortic occlusion. No complications of bleeding or distal embolization occurred during streptokinase t...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1983-04-01 00:00:00
abstract::No new chemotherapy agents have been developed recently that present hope for improving survival in patients with colon or rectal cancer. We undertook this study to investigate a new route of administering an old drug, 5-fluorouracil (5-FU). Sixty-six patients with advanced primary colon or rectal cancer were randomiz...
journal_title:Surgery
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1985-09-01 00:00:00
abstract:BACKGROUND:Chronic pancreatitis remains a challenging inflammatory disease, causing progressive, irreversible fibrosis of the pancreatic parenchyma. Several surgical options for treatment have been established, but duodenum-preserving pancreatic head resections seem to be the most favorable option other than pancreatod...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2018.11.009
更新日期:2019-05-01 00:00:00
abstract::We studied the effect of partial excision and wound closure on the postburn hypermetabolic state. A 25% of total body surface burn was produced in seven sheep. Oxygen consumption (VO2) was significantly increased to 215 +/- 44 ml/min/M2 by day 3 compared with baseline of 125 +/- 21 ml/min/M2. The calculated increase w...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1988-11-01 00:00:00
abstract::Heterotopic rat heart allografts were performed in 35 rats. At intervals after transplantation, rats were killed and tissue concentrations of immunoassayable prostaglandin E (PGE) were measured in the native heart, transplanted heart, spleen, and thymus. A significant increase in allograft PGE activity was observed at...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1975-10-01 00:00:00
abstract:BACKGROUND:There is not enough evidence to establish an appropriate surveillance strategy after operative resection for intraductal papillary mucinous neoplasm. METHODS:This study included 257 consecutive intraductal papillary mucinous neoplasm patients who underwent operative resection between July 1999 and March 201...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2016.04.007
更新日期:2016-08-01 00:00:00
abstract::Eleven patients with previous esophageal atresia repair (TEF) underwent esophageal motility studies and were compared to 10 normal patients. The upper sphincters (UES) in the two groups did not differ in resting pressure, contraction pressure, or coordination. UES relaxation, was 100% in normal patients and 83+/-8% in...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract:BACKGROUND:Histopathologic characteristics and optimal treatment modality for superficial esophageal cancer were reevaluated on the basis of 2418 patients from 143 institutions through a nationwide questionnaire to the members of the Japanese Society for Esophageal Diseases. METHODS:A questionnaire was designed for pa...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:After resection of advanced abdominal neuroblastoma, children may have persistent postoperative diarrhea. Until recently, the magnitude of this problem had not been appreciated. METHODS:To assess the incidence, severity, and management of chronic postoperative diarrhea in these patients, we reviewed the cas...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.1998.88092
更新日期:1998-05-01 00:00:00
abstract::The shear stress resistance of cultured human endothelium was investigated on 6 mm polytetrafluoroethylene vascular grafts. Endothelial cell attachment was promoted by precoating the grafts with fibrin glue, which contained human fibronectin and inhibitors of fibrinolysis (aprotinin and tranexam acid). To evaluate the...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:We determined the effect of infusing the iron chelator deferoxamine complexed to hetastarch on the degree of lung dysfunction and systemic abnormalities produced by a severe smoke exposure. METHODS:Adult sheep were given a smoke exposure under anesthesia that produced a peak carboxyhemoglobin between 40% an...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80121-8
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Surgical attempts to treat obesity began because of the discouraging results of conservative medical treatment, which successfully achieved initial weight loss but failed to maintain it. Gastric restrictive procedures, currently the most popular surgical methods for obesity therapy, have proved to be effecti...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80111-5
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Carcinoid tumors of the duodenum are rare, and their natural history has not been defined. Consequently, there is no consensus on the optimal extent of surgical treatment. METHODS:The authors reviewed the records of all patients with primary carcinoid tumors of the duodenum treated at their institution from...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.09.016
更新日期:2005-12-01 00:00:00
abstract::To determine the relative value of carotid phonoangiography (CPA), oculoplethysmography-Kartchner (OPG-K), and Doppler ultrasonic arteriography (UA), 90 vessels undergoing carotid endarterectomy were prospectively examined. By analyzing the data on receiver operator characteristic curves, the dynamic relationship betw...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1980-01-01 00:00:00
abstract:BACKGROUND:Hilar resection, especially in combination with liver resection, results in substantial morbidity and mortality, which clearly influences the overall outcome. In the present study, patients who underwent resection of a proximal bile duct tumor were analyzed with the aim of identifying risk factors for morbid...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1067/msy.2000.104250
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:Groin hernia repair occasionally leads to severe chronic pain associated with entrapped or damaged nerves. Conservative treatment is often unsuccessful. Selective neurectomy may be effective, but long-term results are scarce. The authors assessed the long-term efficacy of surgical neurectomy for chronic, pos...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.08.008
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Depression has been associated with delayed presentation, inadequate treatment, and poor survival in patients with cancer. METHODS:Using Surveillance, Epidemiology and End Results and Medicare linked data (1992-2005), we identified patients with pancreatic adenocarcinoma (N = 23,745). International classifi...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2012.06.010
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Visceral artery aneurysms are an uncommon but important form of abdominal vascular disease. This study reviews a contemporary experience with special emphasis on newer methods of diagnosis and treatment. METHODS:From 1980 to 1994, 37 patients were diagnosed with 46 visceral artery aneurysms. These consisted...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/s0039-6060(96)80009-2
更新日期:1996-10-01 00:00:00
abstract:BACKGROUND:Primary hyperparathyroidism is associated with an increased cardiovascular morbidity and mortality. However, mechanisms underlying this association are currently unclear. As there is clear evidence of the independent role of aldosterone on the cardiovascular system, the aim of this study was to evaluate aldo...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2009.09.041
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Early and accurate assessment of the response to neoadjuvant chemotherapy offers the potential to optimize treatment to obtain improved responses. We aimed to predict the response to neoadjuvant chemotherapy using a second breast core needle biopsy after a median of 2 cycles of neoadjuvant chemotherapy. MET...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2020.06.045
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Polymorphonuclear leukocyte (PMN) activation after interaction with implantable surfaces has been previously reported. The purpose of this study was to examine the mechanism of PMN activation in response to expanded polytetrafluoroethylene (ePTFE). METHODS:To demonstrate PMN activation, the cumulative produ...
journal_title:Surgery
pub_type: 杂志文章
doi:
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Survivin is a member of the inhibitor of apoptosis protein family, which inhibits apoptosis and regulates cell division. Survivin is expressed by the majority of human cancers, including pancreatic adenocarcinoma. We have reported that its expression is correlated with shorter survival of pancreatic cancer p...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2005.05.009
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:A minimally invasive step-up approach to necrotizing biliary pancreatitis often requires multiple interventions, delaying cholecystectomy. The risk of gallstone-related complications during this time interval is unknown, as is the feasibility and safety of cholecystectomy after minimally invasive step-up tre...
journal_title:Surgery
pub_type: 杂志文章
doi:10.1016/j.surg.2020.11.002
更新日期:2020-12-12 00:00:00