[The first case of Hb Camden carriage in Russia].

Abstract:

:Structural hemoglobinopathy due to carriage of Hb Camden was diagnosed in a male patient and his mother. Anomalous Hb was detected after a detailed analysis of the clinical evidence, blood smears microscopy, marrow examination, data obtained by a complex of methods to identify unstable Hb. It was defined as Hb Camden beta 131 GLN-->GLU. The carriage of this variant brings no clinical manifestations, but leads to impaired red cells morphology, decline of their life span, enhanced hemolysis. These properties are typical for mutant Hb lacking stability. Hb Camden carriage is considered as a compensatory hemolytic process.

journal_name

Ter Arkh

journal_title

Terapevticheskii arkhiv

authors

Aseeva EA,Lutsenko IN,Pivnik AV,Spivak VA,Beliaeva LS,Kremenetskaia AM,Saad V

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

49-51

issue

7

eissn

0040-3660

issn

2309-5342

journal_volume

65

pub_type

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