Abstract:
:Administration of phenobarbital to chick embryos increased hepatic microsomal UDP-glucuroyltransferase activity some 25-fold. The large phenobarbital-induced increase of UDP-glucuronyltransferase activity was correlated to an equivalent increase of immunochemically measurable UDP-glucuronyltransferase protein. Poly(A+) RNA isolated from the livers of chick embryos treated with either phenobarbital or saline was translated in vitro. Immunochemical analysis of the translation products indicated that phenobarbital induced a 30-fold increase in UDP-GT mRNA. Fractionation of hepatic poly(A+) RNA from phenobarbital-treated chick embryos by sucrose density gradient centrifugation indicated that the size of the UDP-GT mRNA was 21S. These data show that phenobarbital induction of chick embryo liver UDP-glucuronyltransferase activity correlates with a similar large increase in the level of translatable mRNA for this enzyme.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Jackson MR,Kennedy SM,Lown G,Burchell Bdoi
10.1016/0006-2952(86)90159-0subject
Has Abstractpub_date
1986-04-01 00:00:00pages
1191-8issue
7eissn
0006-2952issn
1873-2968pii
0006-2952(86)90159-0journal_volume
35pub_type
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