Abstract：
:The effects of physiological and pathological concentrations of glucocorticoids were investigated using the glucocorticoid antagonist RU486 and the synthetic glucocorticoid dexamethasone, respectively. The effects of these treatments on the concentrations of glutamine and other amino acids in skeletal muscle and plasma and on the rates of release of glutamine and alanine from incubated preparations of skeletal muscle of the rat were investigated. Dexamethasone treatment increased the concentration of glutamine and the rate of release of this amino acid from incubated soleus muscle preparations. This treatment decreased the concentration of glutamine in both gastrocnemius and EDL muscles, but was without effect on the rate of glutamine release from EDL muscles. In contrast, administration of the glucocorticoid antagonist RU486 decreased the rate of glutamine release from muscle. It is concluded that glucocorticoids have marked effects on the metabolism of glutamine by skeletal muscle per se and that these hormones may be important in the control of the rate of glutamine release from muscle in both physiological and pathological conditions.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Parry-Billings M,Leighton B,Dimitriadis GD,Bond J,Newsholme EAdoi
10.1016/0006-2952(90)90505-fsubject
Has Abstractpub_date
1990-09-01 00:00:00pages
1145-8issue
5eissn
0006-2952issn
1873-2968pii
0006-2952(90)90505-Fjournal_volume
40pub_type
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