MicroRNA: A new generation therapeutic target in diabetic nephropathy.

abstract：:Ribonucleotide reductase (RNR), which consists of R1 and R2 subunits, catalyzes a key step of deoxyribonucleoside triphosphate (dNTP) synthesis for DNA replication and repair. The R2 subunit is controlled in a cell cycle-specific manner for timely DNA synthesis and is negatively regulated by p53 in response to DNA dam...

journal_title：Biochemical pharmacology

authors： Lin ZP,Belcourt MF,Carbone R,Eaton JS,Penketh PG,Shadel GS,Cory JG,Sartorelli AC

更新日期：2007-03-15 00:00:00

abstract：:ERCC1 is a critical gene within the nucleotide excision repair pathway. Overexpression of ERCC1 through promoter-mediating transcriptional regulation is associated with repair of cisplatin-induced DNA damage and clinical resistance to platinum-chemotherapy. Several transcriptional repressors and activators within the ...

journal_title：Biochemical pharmacology

authors： Yan QW,Reed E,Zhong XS,Thornton K,Guo Y,Yu JJ

更新日期：2006-03-14 00:00:00

abstract：:An intestinal active transport system specific to small peptides and peptide-like drugs such as beta-lactam antibiotics was functionally expressed in Xenopus laevis oocytes after microinjection of messenger RNA (mRNA) derived from rat intestinal mucosal cells. The transport activity was evaluated by measuring the upta...

journal_title：Biochemical pharmacology

authors： Tamai I,Tomizawa N,Kadowaki A,Terasaki T,Nakayama K,Higashida H,Tsuji A

更新日期：1994-08-30 00:00:00

abstract：:A series of isoquinolines, N-methyl-1,2-dihydroisoquinolines, N-methyl-1,2,3,4-tetrahydroisoquinolines, 1,2,3,4-tetrahydroisoquinolines, and N-methylisoquinolinium ions were tested as inhibitors of monoamine oxidases A and B. All compounds were found to act as reversible and time-independent MAO inhibitors, often with...

journal_title：Biochemical pharmacology

authors： Thull U,Kneubühler S,Gaillard P,Carrupt PA,Testa B,Altomare C,Carotti A,Jenner P,McNaught KS

更新日期：1995-09-07 00:00:00

abstract：:Despite the steadily increased numbers of formyl peptide receptor (FPR) ligands identified over the years, few have been characterized in studies using animal disease models and even less have entered clinical trials in human subjects. A small-molecule compound, Act-389949, was however recently tested in a phase I cli...

journal_title：Biochemical pharmacology

authors： Lind S,Sundqvist M,Holmdahl R,Dahlgren C,Forsman H,Olofsson P

更新日期：2019-08-01 00:00:00

abstract：:Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the deamination of methylamine and aminoacetone to produce toxic aldehydes, i.e. formaldehyde and methylglyoxal, as well as hydrogen peroxide and ammonia. An increase of SSAO activity was detected by different laboratories in patients suffering from vascular disor...

journal_title：Biochemical pharmacology

authors： Yu PH,Davis BA,Deng Y

更新日期：2001-03-15 00:00:00

abstract：:There is increasing evidence that S-nitrosylation is a mechanism for the regulation of protein function via the modification of critical sulfhydryl groups. The activity of rat liver microsomal glutathione S-transferase (GST) is increased after treatment with N-ethylmaleimide (NEM), a sulfhydryl alkylating reagent, and...

journal_title：Biochemical pharmacology

authors： Ji Y,Toader V,Bennett BM

更新日期：2002-04-15 00:00:00

abstract：:This mini-review addresses the effect of glycosylation and phosphorylation on the conformational alterations of the epidermal growth factor receptor (EGFR). Based on studies with full-length and truncated EGFRs, we propose a model to suggest that receptor-receptor self-association, which occurs in the truncated recept...

journal_title：Biochemical pharmacology

authors： Bishayee S

更新日期：2000-10-15 00:00:00

abstract：:Minoxidil sulphotransferase (MST) activity was determined in the cytosolic fraction of rat skin and liver. MST of rat skin is similar to the P (phenol)-form of phenosulphotransferase (PST) of human tissues with respect to thermostability and inhibition by 2,6-dichloro-4-nitrophenol (DCNP). p-Nitrophenol, a prototype s...

journal_title：Biochemical pharmacology

authors： Wong KO,Tan AY,Lim BG,Wong KP

更新日期：1993-03-09 00:00:00

abstract：:Phenobarbital (PB) and certain structurally-related compounds induce a variety of hepatic drug-metabolizing enzymes in many strains of rats. Thus, following administration of PB (300, 500 ppm), barbital (BB, 1500 ppm) or 5-ethyl-5-phenylhydantoin (EPH, 500 ppm), CYP2B1-mediated benzyloxyresorufin O-dealkylase activity...

journal_title：Biochemical pharmacology

authors： Lubet RA,Nims RW,Dragnev KH,Jones CR,Diwan BA,Devor DE,Ward JM,Miller MS,Rice JM

更新日期：1992-03-03 00:00:00

abstract：:The increasing incidence of severe liver diseases worldwide has resulted in a high demand for curative liver transplantation. Unfortunately, the need for transplants by far eclipses the availability of suitable grafts leaving many waitlisted patients to face liver failure and often death. Routine use of smaller grafts...

journal_title：Biochemical pharmacology

authors： Greenbaum LE,Ukomadu C,Tchorz JS

更新日期：2020-05-01 00:00:00

abstract：:We have examined, relative to clofibric acid (CPIB), the effects of a chemical series of phenoxyacetic acids and of two asymmetric CPIB analogues, the R(+)- and S(-)-enantiomers of 2-(4-chlorophenoxy)propionic acid (4-CPPA) and 2-(4-chlorophenoxy)butyric acid (4-CPBA), on hepatic peroxisome proliferation both in vivo ...

journal_title：Biochemical pharmacology

authors： Esbenshade TA,Kamanna VS,Newman HA,Tortorella V,Witiak DT,Feller DR

更新日期：1990-09-15 00:00:00

abstract：:The carrier protein for methotrexate and tetrahydrofolate cofactors (GP-MTX) in CCRF-CEM human lymphoblastic leukemia cells in a 117 kDa glycoprotein containing both N- and O-linked oligosaccharides (Matherly et al., J Biol Chem 267: 23253-23260, 1992). Tunicamycin, an inhibitor of N-glycosylation, was used to investi...

journal_title：Biochemical pharmacology

authors： Matherly LH,Angeles SM

更新日期：1994-03-15 00:00:00

abstract：:Recent studies in our laboratory have revealed that Mn2+ is capable of promoting cell spreading and neurite outgrowth in PC12 cells, a process which is dependent on Mn2+ stimulation of the interaction between extracellular matrix (ECM) components and their corresponding integrin receptors. Since the major ECM proteins...

journal_title：Biochemical pharmacology

authors： Lin WH,Marcucci K,Roth JA

更新日期：1994-04-29 00:00:00

abstract：:Rat erythrocytes were incubated in vitro with various selenium compounds at 37 degrees. Hemolysis occurred with some selenium compounds but not with corresponding sulfur analogues. Selenite induced more rapid loss of intracellular glutathione (GSH) than did selenocystine but was less hemolytic. Cystine caused neither ...

journal_title：Biochemical pharmacology

authors： Hu ML,Spallholz JE

更新日期：1983-03-15 00:00:00

abstract：:Treatment of red blood cells with the copper (II) ascorbate system causes increased lipid peroxidation, increased membrane microviscosity, and phospholipid translocation with a concurrent decrease in cytosolic catalase and glutathione peroxidase activities. All these changes are prevented if the cells are treated with...

journal_title：Biochemical pharmacology

authors： Chattopadhyay A,Choudhury TD,Bandyopadhyay D,Datta AG

更新日期：2000-02-15 00:00:00

abstract：:[3H]Spiperone binding sites were solubilized in high yield from human, dog and rat brain with a mixture of sodium cholate (0.3% w/v) and sodium chloride (1.4 M). The binding sites were not sedimented after one hour at 100,000 g, they passed freely through 0.20 micron filters, migrated as a single peak in gradient sedi...

journal_title：Biochemical pharmacology

authors： Wouters W,van Dun J,Laduron PM

更新日期：1984-12-15 00:00:00

abstract：:It was previously shown that [Pt(O,O'-acac)(γ-acac)(DMS)] induces apoptosis in various cancer cells and exerts antimetastatic responses in vitro. In rats, [Pt(O,O'-acac)(γ-acac)(DMS)] reaches the central nervous system in quantities higher than cisplatin causing less excitotoxicity. The aim of the present paper was to...

journal_title：Biochemical pharmacology

authors： Muscella A,Calabriso N,Vetrugno C,Fanizzi FP,De Pascali SA,Marsigliante S

更新日期：2011-06-01 00:00:00

abstract：:The reduction of penicillamine disulfide by reductants in aqueous solutions has been studied and compared with that for captopril disulfide. Whereas near quantitative reduction for captopril disulfide was achieved with tributyl phosphine (200 mM), no detectable penicillamine was formed from penicillamine disulfide. Th...

journal_title：Biochemical pharmacology

authors： Drummer OH,Routley L,Christophidis N

更新日期：1987-04-15 00:00:00

abstract：:The stereoselective sulfoxidation of the pharmacologically active metabolite of sulindac, sulindac sulfide, was characterized in human liver, kidney, and cDNA-expressed enzymes. Kinetic parameter estimates (pH = 7.4) for sulindac sulfoxide formation in human liver microsomes (N = 4) for R- and S-sulindac sulfoxide wer...

journal_title：Biochemical pharmacology

authors： Hamman MA,Haehner-Daniels BD,Wrighton SA,Rettie AE,Hall SD

更新日期：2000-07-01 00:00:00

abstract：:Cyclic AMP (cAMP) and cyclic GMP (cGMP) are two second messengers that have been proposed to act as a dualistic system in biological regulation. To determine if cGMP plays a role in the mediation of circadian rhythmicity of the adenylate cyclase (AC)-cAMP-phosphodiesterase (PDE) system in the achlorophyllous ZC mutant...

journal_title：Biochemical pharmacology

authors： Tong J,Edmunds LN Jr

更新日期：1993-05-25 00:00:00

abstract：:The effects of pretreatment with 3-methylcholanthrene (MC) and beta-naphthoflavone (beta NF) on the hepatic microsome-mediated mutagenesis of aflatoxin B1 (AFB1) and benzo[a]pyrene, and on the metabolism of aflatoxins B1 and B2, were investigated in inbred mouse strains. The inbred strains of mice studied included Ah ...

journal_title：Biochemical pharmacology

authors： Raina V,Williams CJ,Gurtoo HL

更新日期：1983-12-15 00:00:00

abstract：:Studies have been carried out to analyze the phosphoprotein composition of plasma membranes from Chinese hamster lung cells resistant to the action of adriamycin. Gel electrophoretic analysis of [32Pi]-labeled proteins revealed that plasma membranes from resistant cells contain a phosphoprotein of 180,000 molecular we...

journal_title：Biochemical pharmacology

authors： Garman D,Albers L,Center MS

更新日期：1983-12-01 00:00:00

abstract：:Hepatic stellate cells (HSCs) are the primary source of matrix components in hepatic fibrosis. Ferulic acid (FA) has antifibrotic potential in renal and cardiac disease. However, whether FA comprises inhibitive effects of HSCs activation remains to be clarified. This study aims at evaluating the hypothesis that FA inh...

journal_title：Biochemical pharmacology

authors： Xu T,Pan Z,Dong M,Yu C,Niu Y

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND/AIMS:Carnitine palmitoyl-transferase I (CPT I) catalyses the synthesis of long-chain (LC)-acylcarnitines from LC-acyl-CoA esters. It is the rate-limiting enzyme of mitochondrial fatty acid beta-oxidation (FAO) pathway and its activity is regulated by malonyl-CoA. The antiepileptic drug valproic acid (VPA) is...

journal_title：Biochemical pharmacology

authors： Aires CC,Ijlst L,Stet F,Prip-Buus C,de Almeida IT,Duran M,Wanders RJ,Silva MF

更新日期：2010-03-01 00:00:00

abstract：:One of the most rapidly developing areas of organellar biology, and one with major involvements in biochemical pharmacology, is that of peroxisomal function. In this commentary, several recent research findings in this area are described, along with their significance in relation to the metabolism of drugs and xenobio...

journal_title：Biochemical pharmacology

authors： Masters CJ

更新日期：1998-09-15 00:00:00

abstract：:Somatostatin receptors from rabbit retinal membranes were solubilized in an active form using a mixture of the detergent n-octyl b-D-glucopyranoside (OG) and CHAPS. The binding of [125I]-Try11-somatostatin to the soluble extract was saturable and of high affinity, with an apparent affinity constant (Kd) of 0.60 +/- 0....

journal_title：Biochemical pharmacology

authors： Liapakis G,Politou E,Thermos K

更新日期：1993-05-05 00:00:00

abstract：:A drastic increase in nitric oxide (NO) content was revealed by the EPR method in rat brain cortex and cerebellum under halothane anesthesia. The NO scavenger diethyldithiocarbamate sodium salt (DETC) and ferrous citrate were injected into adult rats 30-60 min before anesthesia. Rats were anesthetized by inhalation of...

journal_title：Biochemical pharmacology

authors： Sjakste N,Baumane L,Meirena D,Lauberte L,Dzintare M,Kalviņs I

更新日期：1999-12-15 00:00:00

abstract：:It has become apparent of late that even in tamoxifen and/or aromatase resistant breast cancers, ERα remains a bona fide therapeutic target. Not surprisingly, therefore, there has been considerable interest in developing Selective ER Degraders (SERDs), compounds that target the receptor for degradation. Currently, ICI...

journal_title：Biochemical pharmacology

authors： Wardell SE,Marks JR,McDonnell DP

更新日期：2011-07-15 00:00:00

abstract：:Our previous work established that hypocholesterolemic agents altered K-ras intracellular localization in lung. Here, we examined K-ras activity to define further its potential importance in lung carcinogenesis. K-ras activity in lungs from male A/J, Swiss and C57BL/6 mice was examined. For 3 weeks, mice consumed eith...

journal_title：Biochemical pharmacology

authors： Calvert RJ,Tepper S,Kammouni W,Anderson LM,Kritchevsky D

更新日期：2006-12-15 00:00:00