Abstract:
:Treatment of red blood cells with the copper (II) ascorbate system causes increased lipid peroxidation, increased membrane microviscosity, and phospholipid translocation with a concurrent decrease in cytosolic catalase and glutathione peroxidase activities. All these changes are prevented if the cells are treated with erythropoietin prior to the exposure to copper (II) ascorbate. The present investigation further indicates that the oxidative damage brought about by copper (II) ascorbate is due to generation of hydroxyl radical and that erythropoietin plays a unique role in protecting the membrane from oxidative damage.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Chattopadhyay A,Choudhury TD,Bandyopadhyay D,Datta AGdoi
10.1016/s0006-2952(99)00277-4subject
Has Abstractpub_date
2000-02-15 00:00:00pages
419-25issue
4eissn
0006-2952issn
1873-2968pii
S0006295299002774journal_volume
59pub_type
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