Cisplatin-induced apoptosis by translocation of endogenous Bax in mouse collecting duct cells.

abstract：:The tumor necrosis factor (TNF) superfamily (TNFSF) includes about thirty structurally related receptors (TNFSFRs) and about twenty protein ligands that bind to one or more of these receptors. Receptors of the tumor necrosis factor (TNF) superfamily (TNFSFRs) are pharmacological targets for treatment of inflammatory a...

journal_title：Biochemical pharmacology

authors： Platania CBM,Ronchetti S,Riccardi C,Migliorati G,Marchetti MC,Di Paola L,Lazzara F,Drago F,Salomone S,Bucolo C

更新日期：2020-08-01 00:00:00

abstract：:Disodium cromoglycate and compounds which elevated levels of cyclic AMP in the mast cell variously inhibited cytotoxic histamine release induced by the surface active agents melittin, Tween 20 and Triton X-100. These results are inconsistent with the postulated effects of the drugs on receptor mediated calcium channel...

journal_title：Biochemical pharmacology

authors： Pearce FL,Clements J

更新日期：1982-07-01 00:00:00

abstract：:Three sulfolipid compounds, 1, 2, and 3, have been isolated from a higher plant, a pteridophyte, Athyrium niponicum, as potent inhibitors of the activities of calf DNA polymerase alpha and rat DNA polymerase beta. The inhibition by the sulfolipids was concentration dependent, and almost complete inhibition of DNA poly...

journal_title：Biochemical pharmacology

authors： Mizushina Y,Watanabe I,Ohta K,Takemura M,Sahara H,Takahashi N,Gasa S,Sugawara F,Matsukage A,Yoshida S,Sakaguchi K

更新日期：1998-02-15 00:00:00

abstract：:A 4',5'-unsaturated 5'-fluoroadenosine inhibitor of S-adenosyl-L-homocysteine hydrolase (SAH hydrolase; EC 3.3.1.1), MDL 28842, was found to inhibit markedly the growth of Plasmodium falciparum in vitro and Plasmodium berghei in mice. Inhibition of P. berghei growth was associated with a large increase in the concentr...

journal_title：Biochemical pharmacology

authors： Bitonti AJ,Baumann RJ,Jarvi ET,McCarthy JR,McCann PP

更新日期：1990-08-01 00:00:00

abstract：:The peripheral benzodiazepine receptor (PBR), an integral protein of the mitochondrial membrane, is involved in the formation of mitochondrial permeability transition (MPT) pores. The opening of the MPT-leading to the dissipation of the inner-mitochondrial transmembrane potential (deltapsi(m))-is considered to be an e...

journal_title：Biochemical pharmacology

authors： Strohmeier R,Roller M,Sänger N,Knecht R,Kuhl H

更新日期：2002-07-01 00:00:00

abstract：:5-Phenylthioacyclouridine (PTAU or 1-[(2-hydroxyethoxy)methyl]-5-phenylthiouracil) was synthesized as a highly specific and potent inhibitor of uridine phosphorylase (UrdPase, EC 2.4.2.3). PTAU has inhibition constant (K(is)) values of 248 and 353 nM towards UrdPase from mouse and human livers, respectively. PTAU was ...

journal_title：Biochemical pharmacology

authors： el Kouni MH,Goudgaon NM,Rafeeq M,Al Safarjalani ON,Schinazi RF,Naguib FN

更新日期：2000-09-15 00:00:00

abstract：:Induction of the breast cancer resistance protein (BCRP/ABCG2) expression has been found in various tissues and cell-types after exposure to chemicals including 17β-estradiol, rosiglitazone, imatinib, as well as aryl hydrocarbon receptor (AhR) activators such as 2,3,7,8-tetrachlorodibenzodioxin, 3-methylcholanthrene (...

journal_title：Biochemical pharmacology

authors： Tompkins LM,Li H,Li L,Lynch C,Xie Y,Nakanishi T,Ross DD,Wang H

更新日期：2010-12-01 00:00:00

abstract：:Following our observation that erythrosine B (FD&C Red No. 3) is a relatively potent inhibitor of the TNF-R-TNFα and CD40-CD154 protein-protein interactions, we investigated whether this inhibitory activity extends to any other protein-protein interactions (PPI) as well as whether any other approved food colors posses...

journal_title：Biochemical pharmacology

authors： Ganesan L,Margolles-Clark E,Song Y,Buchwald P

更新日期：2011-03-15 00:00:00

abstract：:Antioxidant and anti-inflammatory therapy approaches have been in the focus of attention in the treatment of neurodegenerative Parkinson's and Alzheimer's diseases where oxidative stress has been implicated. Tea extracts have been previously reported to possess radical scavenger, iron chelating and anti-inflammatory p...

journal_title：Biochemical pharmacology

authors： Levites Y,Youdim MB,Maor G,Mandel S

更新日期：2002-01-01 00:00:00

abstract：:It has been reported that an extract from Angelica sinensis mainly consisting of polysaccharides (95%) prevented ethanol- or indomethacin-induced gastric mucosal damage (Cho CH et al. Planta Med 2000;66:348-51). However, it is not known whether Angelica sinensis has a direct stimulatory effect on the healing of gastri...

journal_title：Biochemical pharmacology

authors： Ye YN,Liu ES,Shin VY,Koo MW,Li Y,Wei EQ,Matsui H,Cho CH

更新日期：2001-06-01 00:00:00

abstract：:Common marmosets (Callithrix jacchus) are potentially useful nonhuman primate models for preclinical studies. An anti-inflammatory drug, diclofenac is reportedly metabolized mainly by human cytochrome P450 (P450) 2C9 to 4'-hydroxydiclofenac and minorly by P450 3A4 to 5-hydroxydiclofenac that leads to reactive intermed...

journal_title：Biochemical pharmacology

authors： Nakanishi K,Uehara S,Kusama T,Inoue T,Shimura K,Kamiya Y,Murayama N,Shimizu M,Uno Y,Sasaki E,Yamazaki H

更新日期：2018-06-01 00:00:00

abstract：:Microsomal epoxide hydrolase (mEH) catalyzes the hydrolysis of epoxide intermediates derived from drugs and environmental chemicals. The response of in vivo (embryo) and in vitro (embryo fibroblast) tests were analyzed using mEH-null and wild-type mice to determine the relative role of maternal and embryonic mEH in th...

journal_title：Biochemical pharmacology

authors： Miyata M,Motoki K,Tamura E,Furukawa M,Gonzalez FJ,Yamazoe Y

更新日期：2002-03-15 00:00:00

abstract：:We recently found that simvastatin can modulate the nuclear factor-kappaB (NF-kappaB) activation pathway, but whether other statins have similar effects to those of simvastatin is unknown. Therefore, we evaluated the effect six different statins on TNF-induced NF-kappaB activation in human myeloid leukemia cells. We t...

journal_title：Biochemical pharmacology

authors： Ahn KS,Sethi G,Aggarwal BB

更新日期：2008-02-15 00:00:00

abstract：:The advent of drugs targeting tumor-associated prosurvival alterations of cancer cells has changed the interest of antitumor drug development from cytotoxic drugs to target-specific agents. Although single-agent therapy with molecularly targeted agents has shown limited success in tumor growth control, a promising str...

journal_title：Biochemical pharmacology

authors： Perego P,Cossa G,Zuco V,Zunino F

更新日期：2010-11-15 00:00:00

abstract：:OSI-930, a dual c-Kit and KDR tyrosine kinase inhibitor, is reported to have undergone a Phase I dose escalation study in patients with advanced solid tumors. A series of fifteen pyridyl and phenyl analogues of OSI-930 were designed and synthesized. Extensive screening of these compounds led to the discovery that nitr...

journal_title：Biochemical pharmacology

authors： Kuang YH,Patel JP,Sodani K,Wu CP,Liao LQ,Patel A,Tiwari AK,Dai CL,Chen X,Fu LW,Ambudkar SV,Korlipara VL,Chen ZS

更新日期：2012-09-15 00:00:00

abstract：:Reactive oxygen and nitrogen species are overproduced in the cardiovascular system in response to the exposure to doxorubicin, a cardiotoxic anticancer compound. Oxidant-induced cell injury involves the activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) and pharmacological inhibition of PARP has recen...

journal_title：Biochemical pharmacology

authors： Szenczi O,Kemecsei P,Holthuijsen MF,van Riel NA,van der Vusse GJ,Pacher P,Szabó C,Kollai M,Ligeti L,Ivanics T

更新日期：2005-03-01 00:00:00

abstract：:The effect of 3'-deoxythymidin-2'-ene (d4T) on the metabolism of exogenously supplied radiolabeled nucleosides was investigated. Following a 24-hr exposure to 250 microM d4T, we observed no significant effect on the incorporation of [3H]thymidine or [3H]deoxycytidine into DNA. In contrast, the amounts of [3H]uridine, ...

journal_title：Biochemical pharmacology

authors： Marongiu ME,August EM,Prusoff WH

更新日期：1990-05-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death. Different signaling pathways are de-regulated in this pathogenesis, among them the epidermal growth factor receptor one (EGFR/Erb1). Here we show that blockage of this pathway by the tyrphostin 4-(3-chloroanilino)-6,7-dimethoxyqui...

journal_title：Biochemical pharmacology

authors： Caja L,Sancho P,Bertran E,Ortiz C,Campbell JS,Fausto N,Fabregat I

更新日期：2011-12-01 00:00:00

abstract：:The dimeric forms of metallothionein were isolated from livers of rabbits which accumulated cadmium in large quantities. The dimers were separated into three isoproteins, both on a DEAE Sephadex A-25 column and on a gel permeation column. Reduction of each dimer with mercaptoethanol yielded monomeric metallothionein-I...

journal_title：Biochemical pharmacology

authors： Suzuki KT,Yamamura M

更新日期：1980-03-01 00:00:00

abstract：:The 3'-fluoro-and 3'-azido-substituted derivatives of 2',3'-dideoxythymidine (ddThd), 2',3'-dideoxyuridine (ddUrd), 2',3'-dideoxy-5-ethyluridine (ddEtUrd) and 2',3'-dideoxycytidine (ddCyd) have been synthesized and evaluated for their anti-retrovirus activity [against human immunodeficiency virus (HIV) and murine Molo...

journal_title：Biochemical pharmacology

authors： Balzarini J,Baba M,Pauwels R,Herdewijn P,De Clerq E

更新日期：1988-07-15 00:00:00

abstract：:Taxol is an antineoplastic agent with significant activity against ovarian as well as breast cancer. To investigate mechanisms by which taxol exerts its cytotoxic action, taxol-induced apoptosis, characterized by morphologic changes and internucleosomal DNA fragmentation, was examined in a human ovarian tumor cell lin...

journal_title：Biochemical pharmacology

authors： Liu Y,Bhalla K,Hill C,Priest DG

更新日期：1994-09-15 00:00:00

abstract：:Wild-type and repair-deficient cell lines ( EM9 ) of Chinese Hamster Ovary cells were utilized to assess cytotoxic responses towards metals that produce lesions in DNA. Alkaline elution studies indicated that both CaCrO4 and HgCl2 induced single-strand breaks in the DNA. CaCrO4 and HgCl2 treatments of intact Chinese h...

journal_title：Biochemical pharmacology

authors： Christie NT,Cantoni O,Evans RM,Meyn RE,Costa M

更新日期：1984-05-15 00:00:00

abstract：:We have shown previously that acetaldehyde forms stable covalent adducts with tubulin, resulting in impaired microtubule formation. The present study explored the mechanism responsible for impaired microtubule formation caused by the substoichiometric stable binding of acetaldehyde to tubulin. The free tubulin dimer w...

journal_title：Biochemical pharmacology

authors： Smith SL,Jennett RB,Sorrell MF,Tuma DJ

更新日期：1992-07-07 00:00:00

abstract：:This paper presents data on the effects of benfluron and its two metabolites DBF and NOBF on both endogenous and exogenous, respiration in the presence of succinate as substrate, of both P388 murine leukemia and Ehrlich ascites carcinoma cells. The most efficient inhibitors of endogenous and exogenous respiration were...

journal_title：Biochemical pharmacology

authors： Miko M,Krepelka J,Melka M

更新日期：1991-12-11 00:00:00

abstract：:We examined the effects of pyrazoloacridine (PZA), an investigational anticancer agent in clinical trials, on cytotoxicity, DNA synthesis, and DNA damage in MCF-7 human breast carcinoma cells. With PZA concentrations ranging from 0.5 to 50 microM for durations of 3-72 hr, cytotoxicity increased in proportion to the to...

journal_title：Biochemical pharmacology

authors： Grem JL,Politi PM,Berg SL,Benchekroun NM,Patel M,Balis FM,Sinha BK,Dahut W,Allegra CJ

更新日期：1996-06-28 00:00:00

abstract：:Nobiletin is a polymethoxylated flavone found in certain citrus fruits that exhibits various pharmacological effects including anti-inflammatory, antitumor and neuroprotective properties. The present study investigated the effects of nobiletin on insulin sensitivity in obese diabetic ob/ob mice, and the possible mecha...

journal_title：Biochemical pharmacology

authors： Lee YS,Cha BY,Saito K,Yamakawa H,Choi SS,Yamaguchi K,Yonezawa T,Teruya T,Nagai K,Woo JT

更新日期：2010-06-01 00:00:00

abstract：:Miconazole and clotrimazole, members of a class of imidazole agents which have broad spectrum antimycotic activity, were shown to be potent inhibitors of steroid aromatase activity of human placental microsomes. The I50 values for the inhibition of aromatase activity by miconazole, clotrimazole, ketoconazole, and amin...

journal_title：Biochemical pharmacology

authors： Mason JI,Murry BA,Olcott M,Sheets JJ

更新日期：1985-04-01 00:00:00

abstract：:The effect of varying the fatty acid composition of the lipid components of the diet on the activity of epoxide hydratase in the rat liver and intestinal mucosa has been studied. Feeding a 10% cod liver oil diet (containing 18% C20:5 and 11% C22:6) resulted in a 3-fold increase in epoxide hydratase activity in the liv...

journal_title：Biochemical pharmacology

authors： Gower JD,Sayer JW,Wills ED

更新日期：1986-06-15 00:00:00

abstract：:The genus Mycobacterium includes non-pathogenic species such as M. smegmatis, and pathogenic species such as M. tuberculosis, the causative agent of tuberculosis (TB). Treatment of TB requires a lengthy regimen of several antibiotics, whose effectiveness has been compromised by the emergence of resistant strains. New ...

journal_title：Biochemical pharmacology

authors： Lee Y,Mootien S,Shoen C,Destefano M,Cirillo P,Asojo OA,Yeung KR,Ledizet M,Cynamon MH,Aristoff PA,Koski RA,Kaplan PA,Anthony KG

更新日期：2013-07-15 00:00:00

abstract：:The characterization of the potent p38 inhibitor BIRB796 as a dual inhibitor of p38/Jun N-terminal kinases (JNK) mitogen-activated protein kinases (EC 2.7.11.24) has complicated the interpretation of its reported anti-inflammatory activity. To better understand the contribution of JNK2 inhibition to the anti-inflammat...

journal_title：Biochemical pharmacology

authors： Gruenbaum LM,Schwartz R,Woska JR Jr,DeLeon RP,Peet GW,Warren TC,Capolino A,Mara L,Morelock MM,Shrutkowski A,Jones JW,Pargellis CA

更新日期：2009-02-01 00:00:00