Effect of disodium cromoglycate and cyclic AMP-active drugs on cytotoxic histamine release from rat mast cells.

abstract：:The effect of dichlorvos (200 mg/kg body weight) with or without nimodipine (6 mg/kg body weight/day for 3 days, starting 1 day prior to the administration of dichlorvos) on calcium homeostasis was studied in the rat brain. The delayed neurotoxic potential of dichlorvos was assessed in terms of neuropathy target ester...

journal_title：Biochemical pharmacology

authors： Choudhary S,Gill KD

更新日期：2001-11-01 00:00:00

abstract：:The distribution of renal adenosine A(1) receptors was investigated in rats with glycerol- or mercuric chloride (HgCl(2))-induced acute renal failure. Receptors were localised by autoradiography using [(3)H]8-cyclopentyl-1,3-dipropylxanthine ([(3)H]DPCPX), a selective A(1) adenosine receptor antagonist. In saline-inje...

journal_title：Biochemical pharmacology

authors： Smith JA,Whitaker EM,Bowmer CJ,Yates MS

更新日期：2000-03-15 00:00:00

abstract：:Bone morphogenetic proteins (BMPs) are members of a class of ancient, highly conserved signalling molecules that play major roles in embryonic axis determination, organ development, tissue repair, and regeneration throughout the animal kingdom. The bone morphogenetic proteins are potent developmental morphogens that a...

journal_title：Biochemical pharmacology

authors： Kaplan FS,Shore EM

更新日期：1998-02-15 00:00:00

abstract：:The bactericidal effect of metronidazole on Escherichia coli and Bacteroides fragilis can be partially reversed by cysteamine under conditions that lead to the formation of an adduct, the thioether, 4-(2-aminoethyl)thio-2-methylimidazole-1-ethanol (4-ATME). This adduct, which is not mutagenic for the Ames histidine au...

journal_title：Biochemical pharmacology

authors： Yeung TC,Goldman P

更新日期：1983-11-01 00:00:00

abstract：:The cytoprotective effects of propylthiouracil (PTU) were studied in rats treated with the hepatotoxin D-galactosamine (D-GNH2). Five days of PTU pretreatment prior to D-GNH2 caused hypothyroidism and a significant reduction in liver injury as assessed by serum transaminase levels. When PTU was administered as a singl...

journal_title：Biochemical pharmacology

authors： Cooper DS,Carter EA,Kieffer JD,Wands JR

更新日期：1984-11-01 00:00:00

abstract：:The present study aimed to investigate endothelin-1 (ET-1) receptors in human and swine cardiomyocytes with binding studies using ET(A) and ET(B) selective receptor antagonists (BMS-182874 and BQ-788, respectively). Cell distribution of mRNA expression for ET(A) and ET(B) subtypes was investigated by in situ hybridiza...

journal_title：Biochemical pharmacology

authors： Modesti PA,Vanni S,Paniccia R,Perna A,Maccherini M,Lisi G,Sani G,Neri Serneri GG

更新日期：1999-07-15 00:00:00

abstract：:Ischemia/reperfusion (I/R) injury constitutes a major reason for failure of liver surgeries and transplantation. I/R injury is more severe in steatotic livers and limits their use in transplantation. Here, we present a novel and selective Toll-like receptor 9 (TLR9) antagonist COV08-0064 and test its potential to prot...

journal_title：Biochemical pharmacology

authors： Shaker ME,Trawick BN,Mehal WZ

更新日期：2016-07-15 00:00:00

abstract：:When human saliva obtained after cigarette smoking was incubated in the presence of tryptamine, the formation of 1,2,3,4-tetrahydro-beta-carboline (TBC) and 1-methyl-1,2,3,4-tetrahydro-beta-carboline (MTBC) was observed in a short time. After incubation with tryptamine (2.5 micrograms/microliter) for 10 min, the conce...

journal_title：Biochemical pharmacology

authors： Tsuchiya H,Ohtani S,Yamada K,Tajima K,Sato M

更新日期：1995-12-22 00:00:00

abstract：:The mechanism of activation of microsomal glutathione transferase in isolated liver cells by diisapropylidene acetone (phorone) was investigated. Phorone (1 mM) causes a time-dependent increase (up to 2.6-fold) in the glutathione transferase activity of microsomes isolated from treated hepatocytes. Since phorone react...

journal_title：Biochemical pharmacology

authors： Lundqvist G,Morgenstern R

更新日期：1992-01-22 00:00:00

abstract：:A comparative study of the N-B transition and the drug binding properties of human serum albumin samples from various sources has been carried out with the help of circular dichroism and equilibrium dialysis. It was found that when warfarin was used as a marker the midpoint pH and the cooperative nature of the N-B tra...

journal_title：Biochemical pharmacology

authors： Dröge JH,Wilting J,Janssen LH

更新日期：1982-12-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of myricitrin, a flavonoid with anti-inflammatory and antinociceptive action, upon persistent neuropathic and inflammatory pain. The neuropathic pain was caused by a partial ligation (2/3) of the sciatic nerve and the inflammatory pain was induced by an intra...

journal_title：Biochemical pharmacology

authors： Meotti FC,Missau FC,Ferreira J,Pizzolatti MG,Mizuzaki C,Nogueira CW,Santos AR

更新日期：2006-12-15 00:00:00

abstract：:As previously shown with isolated oxyhemoglobin, methemoglobin formation can also be induced in intact erythrocytes by hydroxylamine compounds and substituted phenols such as butylated hydroxyanisole (BHA). Electron spin resonance investigations revealed that, accordingly, free radical intermediates were formed in ery...

journal_title：Biochemical pharmacology

authors： Stolze K,Dadak A,Liu Y,Nohl H

更新日期：1996-12-24 00:00:00

abstract：:The mechanism for formation of high-affinity binding of 1-(2,6-dichlorobenzylidene-amino)-3-hydroxyguanidine (guanoxabenz) to alpha2-adrenoceptors was studied in particulate fractions from the rat spleen. The proportion of apparent high versus low-affinity alpha2-adrenoceptor binding sites increased with increasing in...

journal_title：Biochemical pharmacology

authors： Uhlén S,Dambrova M,Tiger G,Oliver DW,Wikberg JE

更新日期：1998-11-01 00:00:00

abstract：:The ability of adrenergic catechol derivatives, including dobutamine, dopamine, and isoproterenol, to inhibit lipid peroxidation was examined. All the catechol derivatives we tested strongly inhibited lipid peroxidation. Dobutamine was a more powerful inhibitor of iron-catalyzed lipid peroxidation than the other agent...

journal_title：Biochemical pharmacology

authors： Miura T,Muraoka S,Ogiso T

更新日期：1998-06-15 00:00:00

abstract：:We have recently reported evidence that a simple beta-linked alkylated mannose reversibly increased the magnitude of GABA(A) receptor currents evoked in cultured rat pyramidal neurons whilst concomitantly reducing the incidence of spontaneous synaptic activity. In this present study, the effects of the simple beta-lin...

journal_title：Biochemical pharmacology

authors： Rezai N,Duggan C,Cairns D,Lees G,Chazot PL

更新日期：2003-02-15 00:00:00

abstract：:3'-azido-3'-deoxythymidine (AZT) is a staple of highly active antiretroviral therapy (HAART). Prior to HAART, long-term use of high-dosage AZT caused myopathy, cardiomyopathy, and hepatotoxicity, associated with mitochondrial DNA depletion. As a component of HARRT, AZT causes cytopenias and lipodystrophy. AZT-5'-triph...

journal_title：Biochemical pharmacology

authors： Lynx MD,Bentley AT,McKee EE

更新日期：2006-04-28 00:00:00

abstract：:The tissue distributions of debrisoquine 4-monooxygenase and bufuralol 1'-monooxygenase activities in microsomes from bovine and rabbit tissues were analysed. Debrisoquine 4-monooxygenase and bufuralol 1'-monooxygenase activities were found in liver, and at low levels in cerebral cortex, kidney cortex, lung, small int...

journal_title：Biochemical pharmacology

authors： Matsuo Y,Iwahashi K,Ichikawa Y

更新日期：1992-05-08 00:00:00

abstract：:Acetaminophen (APAP)-induced hepatotoxicity is the main cause of drug-induced liver injury. This study investigated the protection of baicalin and its aglycone baicalein against APAP-induced hepatotoxicity and its mechanism. Baicalein and baicalin alleviated APAP-induced hepatotoxicity both in vitro and in vivo. Moreo...

journal_title：Biochemical pharmacology

authors： Shi L,Hao Z,Zhang S,Wei M,Lu B,Wang Z,Ji L

更新日期：2018-04-01 00:00:00

abstract：:Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is an active constituent of Rheum palmatum, and showed inhibitory activity on lipopolysaccharide-induced NO production in our previous study. However, the apoptosis-inducing activity of emodin has remained undefined. Among three structurally related anthraquinones, inclu...

journal_title：Biochemical pharmacology

authors： Chen YC,Shen SC,Lee WR,Hsu FL,Lin HY,Ko CH,Tseng SW

更新日期：2002-12-15 00:00:00

abstract：:The ability of gold coordination complexes to bind to DNA and produce inter-strand cross-links in DNA was assessed in an assay system based on the fluorescence properties of the DNA intercalative dye, ethidium bromide. Results from these studies using a variety of gold(I) and gold(III) complexes suggest that the abili...

journal_title：Biochemical pharmacology

authors： Mirabelli CK,Zimmerman JP,Bartus HR,Sung CM,Crooke ST

更新日期：1986-05-01 00:00:00

abstract：:The 2-hydroxylation of desmethylimipramine (DMI) correlates strongly with the 4-hydroxylation of debrisoquine (D) both in human volunteers and in vitro comparing human liver microsomes from different individuals. D competitively inhibits the 2-hydroxylation of DMI in vitro suggesting that DMI is hydroxylated by the 'd...

journal_title：Biochemical pharmacology

authors： von Bahr C,Spina E,Birgersson C,Ericsson O,Göransson M,Henthorn T,Sjöqvist F

更新日期：1985-07-15 00:00:00

abstract：:Previous studies of platinum(II) compounds with bidentate leaving ligands have emphasized the contrast between the stability of the bidentate leaving ligand in vitro (T1/2 greater than 11 days in water) and the apparent reactivity of these bidentate platinum compounds in vivo. However, none of these studies actually m...

journal_title：Biochemical pharmacology

authors： Mauldin SK,Plescia M,Richard FA,Wyrick SD,Voyksner RD,Chaney SG

更新日期：1988-09-01 00:00:00

abstract：:A major problem in the treatment of cancer is cellular resistance to cytotoxic drugs. In tumor cells in vitro, the development of multidrug resistance is usually accompanied by increased expression of drug transporters, either P-glycoprotein (P-gp) or multidrug resistance-associated protein (MRP(1)). Both proteins bel...

journal_title：Biochemical pharmacology

authors： Marbeuf-Gueye C,Priebe W,Garnier-Suillerot A

更新日期：2000-11-15 00:00:00

abstract：:Acute administration of alpha-naphthylisothiocyanate (ANIT) to rats has been used as a model of intrahepatic cholestasis. The mechanism of toxicity of ANIT is unknown, although recent evidence suggests a causal or permissive role for glutathione (GSH) (Dahm LJ and Roth RA, Biochem Pharmacol 42: 1181-1188, 1991). In th...

journal_title：Biochemical pharmacology

authors： Dahm LJ,Bailie MB,Roth RA

更新日期：1991-08-22 00:00:00

abstract：:Rats fed 1% paracetamol in the diet failed to grow and a dose-dependent inhibition of growth was observed and found to be independent of hepatoxicity. Addition of 0.5% D- or L-methionine, or L-cysteine to a diet containing 1% paracetamol restored growth. Addition of L-methionine to the drinking water was equally effec...

journal_title：Biochemical pharmacology

authors： McLean AE,Armstrong GR,Beales D

更新日期：1989-01-15 00:00:00

abstract：:Local anaesthetics and opioid drugs function synergistically to provide analgesia. In the present study, the nature of this synergy has been investigated using in vitro radioligand binding to determine whether the local anaesthetics bupivacaine and tetracaine modulate the binding of two kappa-opioid receptor ligands, ...

journal_title：Biochemical pharmacology

authors： Fraser GL,Fowler CJ

更新日期：1995-03-30 00:00:00

abstract：:Adenosine is an endogenous nucleoside that regulates many physiological processes through the activation of its four receptors: A(1), A(2A), A(2B) and A(3). Previous studies have identified the involvement of A(2) receptors in the inhibitory activity of adenosine analogues on tumor necrosis factor-alpha (TNF-alpha) pr...

journal_title：Biochemical pharmacology

authors： Zhang JG,Hepburn L,Cruz G,Borman RA,Clark KL

更新日期：2005-03-15 00:00:00

abstract：:A new analogue of methotrexate was synthesized from 4-amino-4-deoxy-N10-methylpteroic acid and D,L-homocysteic acid. The product (mAPA-HCysA) was bound tightly to L1210 mouse leukemia dihydrofolate reductase (IC50 = 1 nM), inhibited L1210 cell proliferation in culture (IC50 = 0.3 microM), and prolonged the survival of...

journal_title：Biochemical pharmacology

authors： Rosowsky A,Moran RG,Forsch R,Colman P,Uren J,Wick M

更新日期：1984-01-01 00:00:00

abstract：:The effect of thiopental on glutamate metabolism was studied by 13C magnetic resonance spectroscopy. Cerebral cortical astrocytes were incubated with 0.5 mM [U-13C]glutamate for 2 hr in the presence of 0.5 or 1 mM thiopental. Labeled glutamate, glutamine, aspartate, and glutathione were observed in cell extracts, and ...

journal_title：Biochemical pharmacology

authors： Qu H,Faerø E,Jørgensen P,Dale O,Gisvold SE,Unsgård G,Sonnewald U

更新日期：1999-09-15 00:00:00

abstract：:Our results indicate that sex hormones play an important role in the regulation of brain and hepatic GST protein during maturity. The conjugating factor GSH does not appear to be under the influence of sex hormones. These observations are of great significance in view of the possibility of continued exposure to neurot...

journal_title：Biochemical pharmacology

authors： Das M,Agarwal AK,Seth PK

更新日期：1982-12-01 00:00:00