Abstract：
:The bactericidal effect of metronidazole on Escherichia coli and Bacteroides fragilis can be partially reversed by cysteamine under conditions that lead to the formation of an adduct, the thioether, 4-(2-aminoethyl)thio-2-methylimidazole-1-ethanol (4-ATME). This adduct, which is not mutagenic for the Ames histidine auxotrophs of Salmonella typhimurium, forms at a rate that is independent of live bacterial cells and, therefore, can not be shown to relate to the biological effect of cysteamine. When treated with Raney nickel, this adduct yields 2-methylimidazole-1-ethanol. To determine whether a structurally related adduct forms with bacterial protein, a culture of B. fragilis was incubated with radiolabelled metronidazole and then treated with 5% trichloroacetic acid. That the radiolabel in the precipitate did not yield 2-methylimidazole-1-ethanol when treated with Raney nickel suggests that binding of metronidazole to cellular macromolecules does not involve thioether formation.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Yeung TC,Goldman Pdoi
10.1016/0006-2952(83)90196-xsubject
Has Abstractpub_date
1983-11-01 00:00:00pages
3145-9issue
21eissn
0006-2952issn
1873-2968pii
0006-2952(83)90196-Xjournal_volume
32pub_type
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
doi：10.1016/0006-2952(82)90082-x
更新日期：1982-10-01 00:00:00
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journal_title：Biochemical pharmacology
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doi：10.1016/0006-2952(82)90710-9
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journal_title：Biochemical pharmacology
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更新日期：1996-11-08 00:00:00
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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更新日期：2000-01-15 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Biochemical pharmacology
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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journal_title：Biochemical pharmacology
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journal_title：Biochemical pharmacology
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journal_title：Biochemical pharmacology
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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更新日期：1992-03-17 00:00:00
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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更新日期：2002-06-15 00:00:00
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journal_title：Biochemical pharmacology
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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更新日期：2009-05-01 00:00:00
