Abstract：
:Stress, be it from environmental factors or intrinsic to the cell as result of growth and metabolism, can be harmful to cells. Mammalian cells have developed numerous mechanisms to respond to diverse forms of stress. These mechanisms combine signaling cascades and activation of gene expression programs to orchestrate an adaptive response that will allow the cell to survive and resume its normal functioning. In this review we will focus on the transcription factor NFAT5, a fundamental regulator of the response to osmotic stress in mammalian cells. Identified in 1999, NFAT5 is the latest addition to the Rel family, which comprises the NF-kappaB and NFATc proteins. Though in some of its structural and functional features NFAT5 is a hybrid between these two major groups of Rel proteins, it has unique characteristics that make it stand on its own as a third type of Rel transcription factor. Since its discovery, NFAT5 has been studied mostly in the context of the hypertonicity stress response. The advent of mouse models deficient in NFAT5 and other recent advances have confirmed a fundamental osmoprotective role for this factor in mammals, but also revealed features that suggest it may have a wider range of functions.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Aramburu J,Drews-Elger K,Estrada-Gelonch A,Minguillón J,Morancho B,Santiago V,López-Rodríguez Cdoi
10.1016/j.bcp.2006.07.002subject
Has Abstractpub_date
2006-11-30 00:00:00pages
1597-604issue
11eissn
0006-2952issn
1873-2968pii
S0006-2952(06)00417-5journal_volume
72pub_type
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