Abstract:
:The inhibition of rat liver monoamine oxidase by a number of N-propargyl and alpha-methyl amine derivatives has been examined. The results indicate that alpha-methyl-substituted primary and secondary amine derivatives tend to show selectivity as reversible inhibitors towards the A-form of the enzyme. The structural features that result in selectivity in irreversible inhibitors are less easy to define and substitution of an N-propargyl group into a compound that is a selective reversible inhibitor of monoamine oxidase will not necessarily result in retention of that selectivity. Replacement of the acetylenic group in a B-selective irreversible inhibitor by an ethylenic group resulted in a compound that was a reversible inhibitor showing slight selectivity for the A-form of the enzyme.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Tipton KF,McCrodden JM,Kalir AS,Youdim MBdoi
10.1016/0006-2952(82)90012-0subject
Has Abstractpub_date
1982-04-01 00:00:00pages
1251-5issue
7eissn
0006-2952issn
1873-2968pii
0006-2952(82)90012-0journal_volume
31pub_type
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