Abstract:
:This review has highlighted some of the well-described differences in endothelial cells derived from different sites of the vascular tree. In presenting a select group of endothelial properties, there was no intention to imply that these are the only properties of endothelial cells that exhibit heterogeneity. Nonetheless, having described endothelial heterogeneity in regard to a number of defined properties, we are left with persistent questions including: Are these divergent properties of endothelial cells fixed? Alternatively, can we alter the properties of endothelial cells by affecting the signals from the environment? A number of reports strongly suggest that endothelial cells are capable of acquiring new properties. Stewart and Wiley investigated the role of the neural tissue environment on the differentiation of brain capillary endothelial cells. These authors transplanted ectopic sites, i.e. vascular segments of brain from very young quail embryos to chick coeliac cavity, and a quail somites to chick brain ventricles. The distinctive morphology of quail cells provided a cell marker to differentiate host from graft. The results of this study demonstrated that mesenteric or somatic vessels growing into grafted brain developed functional, structural and histochemical features specific for neural capillaries. Conversely, capillaries in mesodermal tissue that had been grafted to the brain were devoid of the neural capillary characteristics, indicating that brain vessels do not form a barrier when they are made to vascularize non-neural tissue. Milici and Carley reported that bovine adrenal capillary cells cultured on plastic exhibited occasional diaphragmed fenestrations and no transendothelial channels. However, if these same cells were cultured on a basement membrane (matrix) laid down by MDCK cells (a canine nephron epithelial cell line), the cells responded by increasing the number of diaphragmed fenestrations and transendothelial channels. This cell culture study supported an earlier whole animal study in which the importance of the epithelium and/or epithelial basal lamina in the maintenance of endothelial ultrastructure was demonstrated in a developmental study of rat intestinal capillaries. In this earlier study, it was noted that epithelial development coincided with the formation of fenestrations by the endothelium. Enzymatic activities of endothelial cells can also be altered by environmental signals. For example, primary cerebral microvascular endothelial cells exhibit barrier features and are enriched in gamma-glutamyl transpeptidase activity, yet rapidly lose the activity when subcultured.(ABSTRACT TRUNCATED AT 400 WORDS)
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Gerritsen MEdoi
10.1016/0006-2952(87)90252-8subject
Has Abstractpub_date
1987-09-01 00:00:00pages
2701-11issue
17eissn
0006-2952issn
1873-2968pii
0006-2952(87)90252-8journal_volume
36pub_type
杂志文章,评审abstract::Extrahepatic cytochrome P450 enzymes (CYP450) are pivotal in the metabolism of endogenous substrates and xenobiotics. CYP2J2 is a major cardiac CYP450 and primarily metabolizes polyunsaturated fatty acids such as arachidonic acid to cardioactive epoxyeicosatrienoic acids. Due to its role in endobiotic metabolism, CYP2...
journal_title:Biochemical pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.bcp.2017.02.017
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abstract::The effects of chronic lead exposure on mRNA expression, ADP-ribosylation and photoaffinity labeling with [alpha-32P]guanine triphosphate-gamma-azidoanilide ([32P]GTP-A) of alpha i or alpha s subunit of G protein were investigated in neurons isolated from the brain of neonatal and adult rats exposed to lead acetate or...
journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(93)90255-u
更新日期:1993-03-09 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2006.02.013
更新日期:2006-05-28 00:00:00
abstract::Multiple molecular forms of cyclic nucleotide phosphodiesterase have been characterized in various tissues and cells according to their substrate specificity, intracellular location, and calmodulin dependence. The purpose of this study was to evaluate the possible involvement of different molecular forms of phosphodie...
journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(90)90304-4
更新日期:1990-08-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/s0006-2952(02)00978-4
更新日期:2002-06-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
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更新日期:2003-09-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(92)90595-a
更新日期:1992-03-03 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(95)00265-2
更新日期:1995-10-12 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.bcp.2007.06.025
更新日期:2007-10-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2018.04.002
更新日期:2018-06-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/s0006-2952(97)00226-8
更新日期:1997-09-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2005.11.019
更新日期:2006-02-28 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/s0006-2952(00)00418-4
更新日期:2000-10-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.bcp.2013.06.016
更新日期:2014-01-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(92)90501-9
更新日期:1992-03-17 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2007.05.007
更新日期:2007-08-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2007.01.001
更新日期:2007-04-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章,评审
doi:10.1016/j.bcp.2004.04.022
更新日期:2004-09-15 00:00:00
abstract::Adenosine is an endogenous nucleoside that regulates many physiological processes through the activation of its four receptors: A(1), A(2A), A(2B) and A(3). Previous studies have identified the involvement of A(2) receptors in the inhibitory activity of adenosine analogues on tumor necrosis factor-alpha (TNF-alpha) pr...
journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2004.12.008
更新日期:2005-03-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/s0006-2952(02)01623-4
更新日期:2003-03-01 00:00:00
abstract::Boldine ([S]-2,9-dihydroxy-1,10-dimethoxyaporphine) has been shown to exert antioxidant and anti-inflammatory effects. The present study elucidated the protective effect of boldine on catecholamine-induced membrane permeability transition in brain mitochondria and viability loss in PC12 cells. Dopamine (200 microM) an...
journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/s0006-2952(01)00852-8
更新日期:2002-02-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(87)90573-9
更新日期:1987-12-01 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2005.01.017
更新日期:2005-04-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2010.08.004
更新日期:2010-11-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(82)90158-7
更新日期:1982-02-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(93)90236-p
更新日期:1993-06-22 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2003.08.008
更新日期:2003-12-15 00:00:00
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journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/j.bcp.2005.01.005
更新日期:2005-04-01 00:00:00
abstract::The concentrations of dopamine (DA), m-tyramine (mTA), p-tyramine (pTA) and serotonin (5-HT) in the striata of rats 18 hr after the administration of three different doses (5, 50, or 100 mg/kg) of beta-phenylethylhydrazine (phenelzine, PEH) were measured. These concentrations were compared to those following the admin...
journal_title:Biochemical pharmacology
pub_type: 杂志文章
doi:10.1016/0006-2952(83)90475-6
更新日期:1983-05-01 00:00:00