Abstract：
:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a commercially available chemical reagent. Although little has been known about its biological effects, recently MPTP has been reported to cause irreversible Parkinson's disease-like symptoms in humans and in monkeys. We describe here another pharmacologic effect of MPTP, the ability to deplete cardiac norepinephrine in rats and mice. In mice, cardiac norepinephrine concentration decreased within 1 hr, was maximally depleted at 24 hr, and recovered by 4-7 days after i.p. injection of a 32 mg/kg dose of MPTP. The depletion was antagonized by desipramine pretreatment, as was norepinephrine depletion by tyramine. In rats, cardiac norepinephrine depletion by 10-30 mg/kg, i.p., doses of MPTP was accompanied by depletion of cardiac dopamine and of norepinephrine in the mesenteric artery. In rats and in mice, norepinephrine in brain was affected to a smaller degree than was norepinephrine in heart, and dopamine in brain was depleted very little if at all. In spontaneously hypertensive rats, the depletion of cardiac norepinephrine was associated with a marked antihypertensive effect. The p-hydroxy analog of MPTP did not deplete cardiac norepinephrine in rats, indicating that its possible formation as a metabolite of MPTP was not involved in the depletion of cardiac norepinephrine. These findings extend the spectrum of known pharmacologic effects of MPTP.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Fuller RW,Hahn RA,Snoddy HD,Wikel JHdoi
10.1016/0006-2952(84)90593-8subject
Has Abstractpub_date
1984-10-01 00:00:00pages
2957-60issue
19eissn
0006-2952issn
1873-2968pii
0006-2952(84)90593-8journal_volume
33pub_type
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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更新日期：1982-07-01 00:00:00
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更新日期：2012-07-01 00:00:00
