Enhancement by beraprost sodium, a stable analogue of prostacyclin, in thrombomodulin expression on membrane surface of cultured vascular endothelial cells via increase in cyclic AMP level.

abstract：:The well-known analgesic and antipyretic drug N-acetyl-p-aminophenol (acetaminophen; APAP) has been previously reported to affect MDR1 expression in rat liver. In this study, we have investigated the effect of subtoxic doses of APAP on MDR1 expression and activity in rat intestine and human intestinal cells. Administr...

journal_title：Biochemical pharmacology

authors： Ghanem CI,Arias A,Novak A,Carpini GD,Villanueva S,Blazquez AG,Marin JJ,Mottino AD,Rubio MC

更新日期：2011-01-15 00:00:00

abstract：:The stimulated uptake of 45Ca2+ into incubated cerebrocortical synaptosomes caused by veratrine (75 microM) was blocked by low concentrations of verapamil (0.5-30 microM) which did not prevent or reduce depolarization as judged by efflux of potassium (K+). However, verapamil did not prevent amino acid neutrotransmitte...

journal_title：Biochemical pharmacology

authors： Norris DK,Bradford HF

更新日期：1985-06-01 00:00:00

abstract：:The effect of methotrexate (MTX) on 6-mercaptopurine (6-MP) metabolism was studied in four human leukemic cell lines in vitro. CCRF-CEM, WI-L2, TBJ, and HL-60 all expressed thiopurine methyltransferase (TPMT) activity. The cells were grown in horse serum-supplemented RPMI 1640 medium to which was added 4 microM of 6-M...

journal_title：Biochemical pharmacology

authors： Giverhaug T,Loennechen T,Aarbakke J

更新日期：1998-05-15 00:00:00

abstract：:Boldine ([S]-2,9-dihydroxy-1,10-dimethoxyaporphine) has been shown to exert antioxidant and anti-inflammatory effects. The present study elucidated the protective effect of boldine on catecholamine-induced membrane permeability transition in brain mitochondria and viability loss in PC12 cells. Dopamine (200 microM) an...

journal_title：Biochemical pharmacology

authors： Youn YC,Kwon OS,Han ES,Song JH,Shin YK,Lee CS

更新日期：2002-02-01 00:00:00

abstract：:A structure-activity study of fourteen chemically related flavonoids was conducted to evaluate their abilities to inhibit glutathione reductase (GR). By comparing the I50 values of flavonoids from different classes possessing an identical hydroxyl configuration, we determined the following order of potency for inhibit...

journal_title：Biochemical pharmacology

authors： Elliott AJ,Scheiber SA,Thomas C,Pardini RS

更新日期：1992-10-20 00:00:00

abstract：:Metabolism of the synthetic steroid 17 beta-hydroxy-11 beta-(4-dimethylaminophenyl)17 alpha-1-propynyl-estra-4,9-dien-3-one (RU486) occurs in the dedifferentiated S-H56-125 variant of Reuber hepatoma. Considering that rat liver cytochrome P450 (P450) monooxygenases are engaged in different oxidative steps of the metab...

journal_title：Biochemical pharmacology

authors： Chasserot-Golaz S,Beck G,Venetianer A

更新日期：1993-12-03 00:00:00

abstract：:Aminoglycoside antibiotics induce a lysosomal phospholipidosis in kidney proximal tubules after conventional therapy in animals and man. We have previously demonstrated that these drugs bind to negatively charged phospholipid bilayers at acid pH and inhibit the activity of lysosomal acid phospholipases in vitro and in...

journal_title：Biochemical pharmacology

authors： Brasseur R,Carlier MB,Laurent G,Claes PJ,Vanderhaeghe HJ,Tulkens PM,Ruysschaert JM

更新日期：1985-04-01 00:00:00

abstract：:Chlorogenic acid (Chl) has been reported to possess a wide range of biological and pharmacological properties including induction of apoptosis of Bcr-Abl(+) chronic myeloid leukemia (CML) cell lines and clinical leukemia samples via inhibition of Bcr-Abl phosphorylation. Here we studied the mechanisms of action of Chl...

journal_title：Biochemical pharmacology

authors： Rakshit S,Mandal L,Pal BC,Bagchi J,Biswas N,Chaudhuri J,Chowdhury AA,Manna A,Chaudhuri U,Konar A,Mukherjee T,Jaisankar P,Bandyopadhyay S

更新日期：2010-12-01 00:00:00

abstract：:We have demonstrated that the simplest steady-state random sequential Bi Bi mechanism is sufficient to explain the previously reported non-hyperbolic kinetics of glutathione S-transferase 3-3 [Pabst MJ et al., J Biol Chem 249: 7140-7150, 1974; Jakobson I et al., Biochem J 177: 861-868, 1979]. The metabolism of 1-chlor...

journal_title：Biochemical pharmacology

authors： Ivanetich KM,Goold RD,Sikakana CN

更新日期：1990-06-15 00:00:00

abstract：:Stimulation of human gingival fibroblasts with histamine elicited an increase in the intracellular concentration of free calcium ([Ca2+]i) and the formation of inositol 1,4,5-trisphosphate (InsP3) in a concentration- and time-dependent manner. The histamine-induced increase in [Ca2+]i was attenuated completely by chlo...

journal_title：Biochemical pharmacology

authors： Niisato N,Ogata Y,Furuyama S,Sugiya H

更新日期：1996-10-11 00:00:00

abstract：:Incubation of cultured embryonic chicken heart cells with transforming growth factor beta 1 (TGF-beta 1) resulted in a concentration- and time-dependent decrease in the number of muscarinic acetylcholine receptors (mAChR), which reached a maximum by 24 hr. Twenty-four hours following TGF-beta 1 treatment, cm2 and cm4 ...

journal_title：Biochemical pharmacology

authors： Jackson DA,Nathanson NM

更新日期：1997-08-15 00:00:00

abstract：:Members of the homologous series of nine antitumour dimethanesulphonic acid esters, with the exception of ethylene dimethanesulphonate (EDMS), were found to cause DNA-DNA interstrand crosslinking in cells derived from the transplantable rodent Yoshida lymphosarcoma. The ability of the series to induce interstrand cros...

journal_title：Biochemical pharmacology

authors： Bedford P,Fox BW

更新日期：1983-08-01 00:00:00

abstract：:Pyridine N-oxide derivatives represent a new class of anti-HIV compounds for which some members exclusively inhibit HIV-1 RT, whereas other members act, additionally or alternatively, at a post-integrational event in the replicative cycle of HIV. A prototype pyridine N-oxide derivative, JPL-32, inhibited tumor necrosi...

journal_title：Biochemical pharmacology

authors： Stevens M,Pannecouque C,De Clercq E,Balzarini J

更新日期：2006-04-14 00:00:00

abstract：:Mevinolin is a potent competitive inhibitor of HMG-CoA reductase, the enzyme catalyzing the major rate-limiting step in cholesterol synthesis. In this study the drug was administered as an intragastric dose at 2.5 mg/kg/day to 10 to 12-week-old lean and obese Zucker female rats over a 5-day period. Mevinolin showed no...

journal_title：Biochemical pharmacology

authors： McCune SA,Jurin RR

更新日期：1987-03-15 00:00:00

abstract：:The role of Ca2+ and protein kinase C (PKC) activity in the release of immunoreactive endothelin-1 (ET-1) from cultured porcine aortic endothelial cells of first or second passage has been studied. ET-1 accumulation within cells and secretion into cell-conditioned medium over 3 and/or 5 hr was measured. Confluent cell...

journal_title：Biochemical pharmacology

authors： Brunner F

更新日期：1995-06-16 00:00:00

abstract：:Poor prognosis in patients with later stage colorectal cancer (CRC) necessitates the search for new treatment strategies. Ceramide, because of its role in orchestrating death cascades in cancer cells, is a versatile alternative. Ceramide can be generated by exposure to chemotherapy or ionizing radiation, or it can be ...

journal_title：Biochemical pharmacology

authors： Morad SA,Madigan JP,Levin JC,Abdelmageed N,Karimi R,Rosenberg DW,Kester M,Shanmugavelandy SS,Cabot MC

更新日期：2013-04-15 00:00:00

abstract：:Several derivatives of N-t-butyl-alpha-phenylnitrone (PBN) such as N-2-(2-ethoxycarbonyl-propyl)-alpha-phenylnitrone (EPPN) have recently been reported to form superoxide spin adducts (t(1/2) ca. 2-7 min at pH 7.0), which are considerably more stable than their respective PBN or DMPO adducts (t(1/2) ca. 10 and 45 s, r...

journal_title：Biochemical pharmacology

authors： Stolze K,Udilova N,Rosenau T,Hofinger A,Nohl H

更新日期：2004-07-01 00:00:00

abstract：:The effect of 3'-deoxythymidin-2'-ene (d4T) on the metabolism of exogenously supplied radiolabeled nucleosides was investigated. Following a 24-hr exposure to 250 microM d4T, we observed no significant effect on the incorporation of [3H]thymidine or [3H]deoxycytidine into DNA. In contrast, the amounts of [3H]uridine, ...

journal_title：Biochemical pharmacology

authors： Marongiu ME,August EM,Prusoff WH

更新日期：1990-05-15 00:00:00

abstract：:The kinetics of the reaction of acetaldehyde (AcH) with the alpha-amino group of several di- and tripeptides to form 2-methylimidazolidin-4-one adducts were determined at pH 7, 4, 37 degrees C, using reverse phase HPLC to separate peptides from adducts. The imidazolidin-4-one structure of the adducts was confirmed by ...

journal_title：Biochemical pharmacology

authors： Fowles LF,Beck E,Worrall S,Shanley BC,de Jersey J

更新日期：1996-05-17 00:00:00

abstract：:Colchiceine, a closely related structural analog of colchicine possessing a C-ring tropolone, has been shown to be a potent inhibitor of microtubule assembly in vitro (I50 = 20 microM). The mechanism of inhibition is mediated through binding to tubulin (KA = 1.2 +/- 0.7 x 10(4) M-1), although potentially not through t...

journal_title：Biochemical pharmacology

authors： Hastie SB,Macdonald TL

更新日期：1990-04-15 00:00:00

abstract：:Silymarin is known to have hepatoprotective and anticarcinogenic effects. Recently, anti-inflammatory effect of silymarin is attracting an increasing attention, but the mechanism of this effect is not fully understood. Here, we report that silymarin protected mice against lipopolysaccharide (LPS)-induced sepsis. In th...

journal_title：Biochemical pharmacology

authors： Kang JS,Jeon YJ,Park SK,Yang KH,Kim HM

更新日期：2004-01-01 00:00:00

abstract：:The cytoprotective effects of propylthiouracil (PTU) were studied in rats treated with the hepatotoxin D-galactosamine (D-GNH2). Five days of PTU pretreatment prior to D-GNH2 caused hypothyroidism and a significant reduction in liver injury as assessed by serum transaminase levels. When PTU was administered as a singl...

journal_title：Biochemical pharmacology

authors： Cooper DS,Carter EA,Kieffer JD,Wands JR

更新日期：1984-11-01 00:00:00

abstract：:Homogenization of rat kidney under isotonic conditions and in the presence of protease inhibitors showed that some 92% of the cyclic AMP phosphodiesterase activity and some 83% of the cyclic GMP phosphodiesterase activity was released into the soluble fraction. Analysis of soluble phosphodiesterase activity by FPLC on...

journal_title：Biochemical pharmacology

authors： Hoey M,Houslay MD

更新日期：1990-07-15 00:00:00

abstract：:Extracellular nicotinamide is well recognized as the primary precursor to the cellular synthesis of NAD. NAD is a pivotal molecule in regulating the energy and redox potentials of cells via synthesis of ATP and NAD(P)/NAD(P)H ratios. NAD turnover in cells is very rapid due to NAD catabolism via ADP-ribosylation reacti...

journal_title：Biochemical pharmacology

authors： Olsson A,Olofsson T,Pero RW

更新日期：1993-03-24 00:00:00

abstract：:Bitter melon (Momordica charantia), commonly known as karela, has been reported to have hypoglycemic, antiviral, antidiabetic, and antitumor activities. In the present study, we have investigated the effects of oral feeding of karela fruit juice on the hepatic cytochrome P450 (CYP) and glutathione S-transferase (GST) ...

journal_title：Biochemical pharmacology

authors： Raza H,Ahmed I,Lakhani MS,Sharma AK,Pallot D,Montague W

更新日期：1996-11-22 00:00:00

abstract：:Naturally soluble rat germ cell adenylate cyclase was inhibited by adenosine and the adenosine analogs, 9-beta-D-arabinofuranosyl adenine (AFA) and 2',5'-dideoxyadenosine (DDA), all of which inhibited hormone-sensitive adenylate cyclases at the "P" site. The IC50 values for adenosine and DDA were approximately 0.1 and...

journal_title：Biochemical pharmacology

authors： Onoda JM,Braun T,Wrenn SM Jr

更新日期：1987-06-15 00:00:00

abstract：:The protective action of cysteine or mercaptopropionylglycine (MPG) in acute ethanol-induced liver injury has been investigated in the rat. Cysteine accelerated clearance of ethanol and acetaldehyde from blood and liver and prevented an increase in hepatic content of triglyceride and serum ornithine carbamoyl transfer...

journal_title：Biochemical pharmacology

authors： Hirayama C,Kishimoto Y,Wakushima T,Murawaki Y

更新日期：1983-01-15 00:00:00

abstract：:Repertaxin is a new non-competitive allosteric blocker of interleukin-8 (CXCL8/IL-8) receptors (CXCR1/R2), which by locking CXCR1/R2 in an inactive conformation prevents receptor signaling and human polymorphonuclear leukocyte (PMN) chemotaxis. Given the unique mode of action of repertaxin it was important to examine ...

journal_title：Biochemical pharmacology

authors： Casilli F,Bianchini A,Gloaguen I,Biordi L,Alesse E,Festuccia C,Cavalieri B,Strippoli R,Cervellera MN,Di Bitondo R,Ferretti E,Mainiero F,Bizzarri C,Colotta F,Bertini R

更新日期：2005-02-01 00:00:00

abstract：:Male ddY mice were given one injection of (1) mercury (mercuric chloride) simultaneously with various doses of selenium (sodium selenite), (2) mercury alone, or (3) various doses of selenium alone. The interaction between mercury and selenium in the liver and kidneys at 1, 5, 24, 120, and 240 hr after administration w...

journal_title：Biochemical pharmacology

authors： Yamamoto I

更新日期：1985-08-01 00:00:00

abstract：:A compound, YM-53792, was identified as an inhibitor of interleukin-2 (IL-2) gene promoter activity, using a Jurkat cell-based reporter system in which the luciferase gene is regulated by the IL-2 gene promoter. Production of IL-2, interleukin-4 (IL-4) and interleukin-5 (IL-5) from human peripheral blood mononuclear c...

journal_title：Biochemical pharmacology

authors： Kuromitsu S,Fukunaga M,Lennard AC,Masuho Y,Nakada S

更新日期：1997-11-01 00:00:00