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Explanation of the non-hyperbolic kinetics of the glutathione S-transferases by the simplest steady-state random sequential Bi Bi mechanism.

Abstract：

:We have demonstrated that the simplest steady-state random sequential Bi Bi mechanism is sufficient to explain the previously reported non-hyperbolic kinetics of glutathione S-transferase 3-3 [Pabst MJ et al., J Biol Chem 249: 7140-7150, 1974; Jakobson I et al., Biochem J 177: 861-868, 1979]. The metabolism of 1-chloro-2,4-dinitrobenzene by rat liver glutathione S-transferase isoenzymes 2-2 and 3-3 and of 1,2-dichloro-4-nitrobenzene by isoenzyme 3-4 was shown to exhibit non-hyperbolic kinetics, which are best fit by the simplest steady-state random sequential Bi Bi mechanism. Neither more complex steady-state mechanisms nor the superimposition of product inhibition or enzyme memory on the simplest steady-state mechanism was necessary to generate non-hyperbolic kinetics for the glutathione S-transferases.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Ivanetich KM,Goold RD,Sikakana CN

doi

10.1016/0006-2952(90)90621-q

subject

Has Abstract

pub_date

1990-06-15 00:00:00

pages

1999-2004

issue

12

eissn

0006-2952

issn

1873-2968

pii

0006-2952(90)90621-Q

journal_volume

39

pub_type

杂志文章

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