Histamine H1 receptor-induced Ca2+ mobilization and prostaglandin E2 release in human gingival fibroblasts. Possible role of receptor-operated Ca2+ influx.

abstract：:Three sulfolipid compounds, 1, 2, and 3, have been isolated from a higher plant, a pteridophyte, Athyrium niponicum, as potent inhibitors of the activities of calf DNA polymerase alpha and rat DNA polymerase beta. The inhibition by the sulfolipids was concentration dependent, and almost complete inhibition of DNA poly...

journal_title：Biochemical pharmacology

authors： Mizushina Y,Watanabe I,Ohta K,Takemura M,Sahara H,Takahashi N,Gasa S,Sugawara F,Matsukage A,Yoshida S,Sakaguchi K

更新日期：1998-02-15 00:00:00

abstract：:The Na(+), K(+)-ATPase is a ubiquitous membrane transport protein in mammalian cells, responsible for establishing and maintaining high K(+) and low Na(+) in the cytoplasm required for normal resting membrane potentials and various cellular activities. The ionic homeostasis maintained by the Na(+), K(+)-ATPase is also...

journal_title：Biochemical pharmacology

authors： Yu SP

更新日期：2003-10-15 00:00:00

abstract：:Sodium orthovanadate is known to promote glucose uptake in muscle and adipose tissues and has been suggested as a possible oral hypoglycemic agent. In addition, insulin-dependent diabetes has been shown to alter the hepatobiliary clearance of several drugs in rats. This study has determined whether orthovanadate, like...

journal_title：Biochemical pharmacology

authors： Watkins JB 3rd,Bauman ME,Beaty TM

更新日期：1993-12-14 00:00:00

abstract：:Studies have been carried out to analyze the phosphoprotein composition of plasma membranes from Chinese hamster lung cells resistant to the action of adriamycin. Gel electrophoretic analysis of [32Pi]-labeled proteins revealed that plasma membranes from resistant cells contain a phosphoprotein of 180,000 molecular we...

journal_title：Biochemical pharmacology

authors： Garman D,Albers L,Center MS

更新日期：1983-12-01 00:00:00

abstract：:The abilities of liver cytosol fractions from the suncus and Sprague-Dawley (SD) rats to N-acetylate aniline, p-aminobenzoic acid, p-aminosalicylic acid and 2-aminofluorene (AF) were compared. The cytosol from rats N-acetylated these substrates at efficient rates, whereas the cytosol from the suncus did not N-acetylat...

journal_title：Biochemical pharmacology

authors： Nakura H,Itoh S,Kusano H,Ishizone H,Deguchi T,Kamataki T

更新日期：1995-10-12 00:00:00

abstract：:We investigated the role played by monoclonal antibody defined classes of cytochrome P-450 in the metabolism of antipyrine, aminopyrine and theophylline. Two enzyme inhibitory monoclonal antibodies (MAb 1-7-1 and MAb 2-66-3) raised to two forms of cytochrome P-450 were used. Microsomes were prepared from the livers of...

journal_title：Biochemical pharmacology

authors： Slusher LB,Park SS,Gelboin HV,Vesell ES

更新日期：1987-07-15 00:00:00

abstract：:The abilities of halothane and the fluoroethane chlorofluorocarbon (CFC) substitutes, FC-123, FC-133a, FC-124, FC-134a and FC-125, to stimulate cytochrome P450 activities and 2-chloro-1,1-difluoroethene (CDE) defluorination in hepatic microsomes from phenobarbital-treated rabbits were compared. At 1% (v/v) each, halot...

journal_title：Biochemical pharmacology

authors： Wang Y,Olson MJ,Baker MT

更新日期：1993-07-06 00:00:00

abstract：:The killing of isolated hepatocytes by N-acetyl-p-benzoquinone imine (NAPQI), the major metabolite of the oxidation of the hepatotoxin acetaminophen, has been studied previously as a model of liver cell injury by the parent compound. Such studies assume that the toxicity of acetaminophen is mediated by NAPQI and that ...

journal_title：Biochemical pharmacology

authors： Harman AW,Kyle ME,Serroni A,Farber JL

更新日期：1991-04-15 00:00:00

abstract：:Improved syntheses, based on Lewis acid-catalyzed nucleosidation, are described for the preparation of 5-alkyl-2'-deoxyuridines. These were converted to their 5'-phosphates with the use of wheat shoot phosphotransferase. The dUMP analogues, 5-ethyl-dUMP and 5-propyl-dUMP, were competitive vs dUMP inhibitors of thymidy...

journal_title：Biochemical pharmacology

authors： Rode W,Kulikowski T,Kedzierska B,Jastreboff M,Shugar D

更新日期：1984-09-01 00:00:00

abstract：:ICRF-193 [meso-2,3-bis(3,5-dioxopiperazine-1-yl)butane], a bisdioxopiperazine compound, has been shown to be a catalytic inhibitor of DNA topoisomerase II by stabilizing the enzyme in the form of a closed "protein clamp," an intermediate form in the catalytic cycle (Roca et al., Proc Natl Acad Sci USA 91: 1781-1785, 1...

journal_title：Biochemical pharmacology

authors： Sato M,Ishida R,Narita T,Kato J,Ikeda H,Fukazawa H,Andoh T

更新日期：1997-09-01 00:00:00

abstract：:The characteristics of the uptake of acetaminophen (N-acetyl-p-aminophenol or paracetamol, APAP) in incubations of isolated rat liver cells were consistent with diffusion of the drug being the predominant mechanism of APAP influx in these cells at concentrations above 0.5 mM. At lower substrate concentrations (below 0...

journal_title：Biochemical pharmacology

authors： McPhail ME,Knowles RG,Salter M,Dawson J,Burchell B,Pogson CI

更新日期：1993-04-22 00:00:00

abstract：:Quantitative RNase protection assays were performed to determine the levels of muscarinic receptor subtype (m1-m5) mRNAs in rat hippocampi. Results showed that the m1, m3, and m4 subtype mRNAs were expressed at relatively high levels, but the levels of the m2 and m5 subtype were very low. Three weeks following aspirat...

journal_title：Biochemical pharmacology

authors： Zang Z,Creese I

更新日期：1997-05-09 00:00:00

abstract：:The regulation of neurotensin-induced phosphoinositide turnover was studied in transfected CHO cells expressing the rat neurotensin receptor. Stimulation of these cells with neurotensin resulted in an important, but transient, increase in inositol phosphate cell content. Preincubation of the cells with neurotensin dra...

journal_title：Biochemical pharmacology

authors： Hermans E,Maloteaux JM

更新日期：1996-06-28 00:00:00

abstract：:The effect of dichlorvos (200 mg/kg body weight) with or without nimodipine (6 mg/kg body weight/day for 3 days, starting 1 day prior to the administration of dichlorvos) on calcium homeostasis was studied in the rat brain. The delayed neurotoxic potential of dichlorvos was assessed in terms of neuropathy target ester...

journal_title：Biochemical pharmacology

authors： Choudhary S,Gill KD

更新日期：2001-11-01 00:00:00

abstract：:Two novel halogenated pyrrolopyrimidine analogues of adenosine, isolated from marine sources, have been examined for pharmacological and biochemical activities. 4-Amino-5-bromo-pyrrolo[2,3-d]pyrimidine, from a sponge of the genus Echinodictyum, had bronchodilator activity at least as potent as theophylline but with a ...

journal_title：Biochemical pharmacology

authors： Davies LP,Jamieson DD,Baird-Lambert JA,Kazlauskas R

更新日期：1984-02-01 00:00:00

abstract：:In order to elucidate the role of mitochondrial dysfunction in paracetamol-induced hepatotoxicity, the effects of paracetamol on the oxygen consumption and ATP content of the isolated perfused rat liver were correlated with parameters of hepatic viability and hepatotoxicity. Paracetamol at 5 g/L reduced the oxygen con...

journal_title：Biochemical pharmacology

authors： Strubelt O,Younes M

更新日期：1992-07-07 00:00:00

abstract：:Metabolic activation of a potent mutagen, 6-aminochrysene, to genotoxic products in a newly developed tester strain, Salmonella typhimurium NM2009, was studied in a rat liver microsomal monooxygenase system containing cytochrome P450 (P450). Since the tester strain was constructed by introducing an O-acetyltransferase...

journal_title：Biochemical pharmacology

authors： Yamazaki H,Shimada T

更新日期：1992-09-01 00:00:00

abstract：:The release of the inflammatory mediators, prostaglandins (PGs), leukotrienes (LT) and lysosomal acid hydrolases (LAH), by macrophages is stimulated by endocytic stimuli such as zymosan. This process can be interfered with by specific inhibitors of phosphatidylcholine (PC) biosynthesis. The diphenylsulfone dapsone and...

journal_title：Biochemical pharmacology

authors： Bonney RJ,Wightman PD,Dahlgren ME,Sadowski SJ,Davies P,Jensen N,Lanza T,Humes JL

更新日期：1983-01-15 00:00:00

abstract：:Aminoglycoside antibiotics induce a lysosomal phospholipidosis in kidney proximal tubules after conventional therapy in animals and man. We have previously demonstrated that these drugs bind to negatively charged phospholipid bilayers at acid pH and inhibit the activity of lysosomal acid phospholipases in vitro and in...

journal_title：Biochemical pharmacology

authors： Brasseur R,Carlier MB,Laurent G,Claes PJ,Vanderhaeghe HJ,Tulkens PM,Ruysschaert JM

更新日期：1985-04-01 00:00:00

abstract：:The proinflammatory cytokine interleukin (IL)-18 appears to be involved in the pathogenesis of diseases associated with immunoactivation and inflammation. Consequently, blockage of IL-18 bioactivity by use of IL-18 binding protein (IL-18 BP) is likely a promising therapeutic concept. In the present study, we investiga...

journal_title：Biochemical pharmacology

authors： Nold M,Hauser IA,Höfler S,Goede A,Eberhardt W,Ditting T,Geiger H,Pfeilschifter J,Mühl H

更新日期：2003-08-01 00:00:00

abstract：:Englitazone (CP 68,722, Pfizer) is a member of a family of drugs known as thiazolidinediones. One member of this family, troglitazone (Rezulin), is currently utilized in the treatment of Type 2 diabetes. Previous studies have focused on the ability of englitazone to increase insulin sensitivity in various tissues. How...

journal_title：Biochemical pharmacology

authors： Adams MD,Raman P,Judd RL

更新日期：1998-06-01 00:00:00

abstract：:CYP3A4 is the most important drug-metabolizing enzyme that is involved in biotransformation of more than 50% of drugs. Pregnane X receptor (PXR) dominantly controls CYP3A4 inducibility in the liver, whereas vitamin D receptor (VDR) transactivates CYP3A4 in the intestine by secondary bile acids. Four major functional P...

journal_title：Biochemical pharmacology

authors： Pavek P,Pospechova K,Svecova L,Syrova Z,Stejskalova L,Blazkova J,Dvorak Z,Blahos J

更新日期：2010-01-15 00:00:00

abstract：:In the present study we have investigated the effect of six antibiotics (penicillin G, ceftazidime, cephotaxime, cephoperazon, ampicillin and piperacillin) on the neutrophil cytolytic activity by using a system constituted of phorbol-12-myristate-13-acetate-triggered neutrophils and 51Cr-labelled lymphoblastoid Daudi ...

journal_title：Biochemical pharmacology

authors： Ottonello L,Dallegri F,Dapino P,Pastorino G,Sacchetti C

更新日期：1991-11-27 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs are used extensively in clinical medicine. In spite of their therapeutic utility, however, they are known to cause significant gastrointestinal and renal toxicities, circumstances that limit their use. The side effects produced in these organs have been attributed mainly to the inh...

journal_title：Biochemical pharmacology

authors： Basivireddy J,Jacob M,Pulimood AB,Balasubramanian KA

更新日期：2004-02-01 00:00:00

abstract：:Chemokine receptor (CKR) signaling forms the basis of essential immune cellular functions, and dysregulated CKR signaling underpins numerous disease processes of the immune system and beyond. CKRs, which belong to the seven transmembrane domain receptor (7TMR) superfamily, initiate signaling upon binding of endogenous...

journal_title：Biochemical pharmacology

authors： Kleist AB,Getschman AE,Ziarek JJ,Nevins AM,Gauthier PA,Chevigné A,Szpakowska M,Volkman BF

更新日期：2016-08-15 00:00:00

abstract：:The inactive anthracycline analog 4-demethoxy-7,9-di-epi-daunorubicin was covalently coupled to polyglutaraldehyde microspheres. The polymer-bound analog acquired significant cytostatic activity as evaluated with doxorubicin resistant and sensitive murine L1210 leukemia cells. A suggested multiple membrane interaction...

journal_title：Biochemical pharmacology

authors： Rogers KE,Tökés ZA

更新日期：1984-02-15 00:00:00

abstract：:The effect of cyclosporin A (CyA) on 2-deoxyglucose (2DG) uptake by soleus muscles of ICR mice was studied in vivo and in vitro. The basal and insulin-stimulated uptakes of 2DG by the muscles as well as the plasma insulin level were significantly decreased by the in vivo treatment of mice with 20 mg/kg/day of CyA for ...

journal_title：Biochemical pharmacology

authors： Ikeuchi M,Kida K,Goto Y,Kaino Y,Matsuda H

更新日期：1992-04-01 00:00:00

abstract：:Tenofovir alafenamide (TAF) can be considered a new prodrug of tenofovir (TFV), as successor of tenofovir disoproxil fumarate (TDF). It is in vivo as potent against human immunodeficiency virus (HIV) at a 30-fold lower dose (10mg) than TDF (300mg). TAF has been approved in November 2015 (in the US and EU), as a single...

journal_title：Biochemical pharmacology

authors： De Clercq E

更新日期：2016-11-01 00:00:00

abstract：:Oligodendrocytes and activated macrophages are involved in the immunopathology of demyelinating disease. In this study, we investigated the in vitro effect of dietary compounds, in particular flavonoids, on oxidative damage in OLN-93 oligodendrocytes and on nitric oxide (NO) production by NR8383 macrophages. Using a c...

journal_title：Biochemical pharmacology

authors： van Meeteren ME,Hendriks JJ,Dijkstra CD,van Tol EA

更新日期：2004-03-01 00:00:00

abstract：:Colchicine disposition involves both active biliary and renal excretion of parent drug, and at least in mammals a substantial fraction undergoes hepatic demethylation prior to excretion. We investigated the biotransformation of [3H]colchicine in a panel of microsomal preparations obtained from sixteen human liver samp...

journal_title：Biochemical pharmacology

authors： Tateishi T,Soucek P,Caraco Y,Guengerich FP,Wood AJ

更新日期：1997-01-10 00:00:00