Abstract:
:The effect of cyclosporin A (CyA) on 2-deoxyglucose (2DG) uptake by soleus muscles of ICR mice was studied in vivo and in vitro. The basal and insulin-stimulated uptakes of 2DG by the muscles as well as the plasma insulin level were significantly decreased by the in vivo treatment of mice with 20 mg/kg/day of CyA for 6 weeks (P less than 0.01 and P less than 0.05), whereas the insulin binding was increased inversely in the muscles from 20 mg/kg/day CyA-treated mice. The insulin-stimulated uptake of 2DG by the muscles was significantly decreased by the in vitro treatment of the muscles with 1, 10 and 100 micrograms/mL of CyA (P less than 0.05 and P less than 0.01, respectively), while the basal uptake of 2DG was not changed by the in vitro treatment of the muscles with CyA. The insulin binding to the muscles was not altered by the in vitro treatment of the muscles with CyA. These findings suggest that CyA affects not only the insulin secretion from the pancreatic islets but also the postbinding mechanisms of insulin action on the glucose transport by the muscles, which may account for a part of the diabetogenic effect of CyA.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Ikeuchi M,Kida K,Goto Y,Kaino Y,Matsuda Hdoi
10.1016/0006-2952(92)90202-tsubject
Has Abstractpub_date
1992-04-01 00:00:00pages
1459-63issue
7eissn
0006-2952issn
1873-2968pii
0006-2952(92)90202-Tjournal_volume
43pub_type
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pub_type: 杂志文章
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更新日期:1992-09-25 00:00:00
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pub_type: 杂志文章
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更新日期:2005-10-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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