Abstract：
:Male mice were exposed via their diet to perfluoro fatty acids of various chain-lengths (2-10 carbon atoms) at different doses (0.02 and 0.1% weight) and for different periods of time (2-10 days). Thereafter, we monitored effects on liver and body weights and a number of hepatic parameters, including mitochondrial protein content, microsomal contents of cytochromes P450 and b5, NADPH-cytochrome P450 reductase activity [measured as NADPH-cytochrome c reductase (EC 1.6.2.3)], microsomal and cytosolic epoxide hydrolase (EC 3.3.2.3) activities, cytosolic DT-diaphorase (EC 1.6.99.2), glutathione transferase (EC 2.5.1.18), glutathione peroxidase (EC 1.11.1.9) and superoxide dismutase (EC 1.15.1.1) activities, and levels of thiobarbituric acid-reactive material (as an indicator of lipid peroxidation) in the mitochondrial subfraction. The most dramatic changes observed were a 5-9-fold increase in mitochondrial protein, a 3-6-fold increase in the microsomal content of cytochrome P450, a 3-10-fold increase in cytosolic DT-diaphorase activity, an approximately 2-fold increase in cytosolic epoxide hydrolase activity and as much as a 60% decrease in the level of thiobarbituric acid-reactive compounds in the mitochondrial fraction. Smaller increases in microsomal epoxide hydrolase activity and decreases in cytosolic glutathione peroxidase activity were also observed. Of the perfluoro fatty acids tested, perfluorooctanoic acid caused the largest changes in the parameters examined here. Dietary exposure of mice to a 0.02% dose of this substance for 10 days results in a maximal or near-maximal effect in most cases.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Permadi H,Lundgren B,Andersson K,DePierre JWdoi
10.1016/0006-2952(92)90383-tsubject
Has Abstractpub_date
1992-09-25 00:00:00pages
1183-91issue
6eissn
0006-2952issn
1873-2968pii
0006-2952(92)90383-Tjournal_volume
44pub_type
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更新日期：1999-10-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2000-01-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/0006-2952(88)90302-4
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pub_type： 杂志文章
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更新日期：1987-11-01 00:00:00
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更新日期：1995-09-07 00:00:00
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更新日期：1993-06-22 00:00:00
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pub_type： 杂志文章
doi：10.1016/0006-2952(82)90029-6
更新日期：1982-04-01 00:00:00
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pub_type： 杂志文章
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