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Behavioural and neurochemical interactions between chronic reserpine and chronic antidepressants. A possible model for the detection of atypical antidepressants.

Abstract：

:Chronic treatment with a low dose of reserpine (0.1 mg/kg) caused rats to become hyperactive in the "open field" apparatus. When mianserin (5 mg/kg) or the selective serotonin uptake inhibitor ORG. 6582 (5 mg/kg) was chronically administered in combination with reserpine, the hyperactivity was attenuated. Both antidepressants were found to reverse the reduction in the noradrenaline concentration of the amygdaloid cortex caused by chronic reserpine treatment. It is proposed that changes in the activity of the noradrenergic system in the amygdaloid cortex may be causally related to the changes in activity of the rats in the "open field" apparatus.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Jancsár SM,Leonard BE

doi

10.1016/0006-2952(83)90329-5

subject

Has Abstract

pub_date

1983-05-15 00:00:00

pages

1569-71

issue

10

eissn

0006-2952

issn

1873-2968

pii

0006-2952(83)90329-5

journal_volume

32

pub_type

杂志文章

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