Abstract：
:Current evidence demonstrates that protein kinase C (PKC) belongs to a group of cell-signaling molecules that are sensitive targets for redox modifications and functional alterations that mediate oxidant-induced cellular responses. Our studies have demonstrated that diminished intracellular GSH was associated to inactivation of classic isoforms and increased activity of novel PKCs, and triggered molecular signals important for cell survival. Loss of GSH and oxidative damage are probably an early signaling event in apoptotic death, which is characterized by the activation of PKC-delta. Apoptotic process consequent to GSH depletion was inhibited by rottlerin, a PKC-delta-specific inhibitor, which exerted a negative effect on oxyradical production. Therefore, it may be concluded that PKC-delta activity is related to reactive oxygen species production and is involved in the pathway leading to apoptosis and growth arrest.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Domenicotti C,Marengo B,Nitti M,Verzola D,Garibotto G,Cottalasso D,Poli G,Melloni E,Pronzato MA,Marinari UMdoi
10.1016/s0006-2952(03)00507-0subject
Has Abstractpub_date
2003-10-15 00:00:00pages
1521-6issue
8eissn
0006-2952issn
1873-2968pii
S0006295203005070journal_volume
66pub_type
杂志文章abstract：:Acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities were examined in several tissues of normal and hypophysectomized male and female rats. Significant sex differences in the mean AChE activities of normal rats were observed in the superior cervical ganglion (three times more activity in males) and...
journal_title：Biochemical pharmacology
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1991-04-15 00:00:00
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journal_title：Biochemical pharmacology
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journal_title：Biochemical pharmacology
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更新日期：1996-11-08 00:00:00
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journal_title：Biochemical pharmacology
pub_type： 杂志文章,评审
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更新日期：2006-03-30 00:00:00
