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Desensitization of neurotensin-induced phosphoinositide hydrolysis in transfected CHO cells.

Abstract：

:The regulation of neurotensin-induced phosphoinositide turnover was studied in transfected CHO cells expressing the rat neurotensin receptor. Stimulation of these cells with neurotensin resulted in an important, but transient, increase in inositol phosphate cell content. Preincubation of the cells with neurotensin dramatically decreased their response to further stimulation. This diminution, which was time-dependent and not related to the availability of phospholipase C substrate, is though to reflect a progressive homologous desensitization of the recombinant neurotensin receptor.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Hermans E,Maloteaux JM

doi

10.1016/0006-2952(96)00108-6

subject

Has Abstract

pub_date

1996-06-28 00:00:00

pages

1749-52

issue

12

eissn

0006-2952

issn

1873-2968

pii

0006-2952(96)00108-6

journal_volume

51

pub_type

杂志文章

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