Cytoprotection against neutrophil-delivered oxidant attack by antibiotics.

abstract：:The concentrations of dopamine (DA), m-tyramine (mTA), p-tyramine (pTA) and serotonin (5-HT) in the striata of rats 18 hr after the administration of three different doses (5, 50, or 100 mg/kg) of beta-phenylethylhydrazine (phenelzine, PEH) were measured. These concentrations were compared to those following the admin...

journal_title：Biochemical pharmacology

authors： Dyck LE,Durden DA,Yu PH,Davis BA,Boulton AA

更新日期：1983-05-01 00:00:00

abstract：:The effects of pretreatment with 3-methylcholanthrene (MC) and beta-naphthoflavone (beta NF) on the hepatic microsome-mediated mutagenesis of aflatoxin B1 (AFB1) and benzo[a]pyrene, and on the metabolism of aflatoxins B1 and B2, were investigated in inbred mouse strains. The inbred strains of mice studied included Ah ...

journal_title：Biochemical pharmacology

authors： Raina V,Williams CJ,Gurtoo HL

更新日期：1983-12-15 00:00:00

abstract：:Binding of the selective D-1 dopamine receptor ligand 125I SCH 23982 was studied using crude plasma membranes derived from human renal cortex. 125I SCH 23982 bound saturably to a single high affinity site (Kd = 650 pM, Bmax = 19 fmol/mg protein). Binding at 37 degrees was rapid and reversible with forward and reverse ...

journal_title：Biochemical pharmacology

authors： Hughes A,Sever P

更新日期：1989-03-01 00:00:00

abstract：:The effect of the calcium channel blocker verapamil (VRP) on the accumulation and retention of vincristine (VCR) has been examined in mice bearing xenografts of human rhabdomyosarcomas. The tumors were Rh18, moderately sensitive to VCR, and its subline, Rh18/VCR3, selected in vivo for primary resistance to VCR. Admini...

journal_title：Biochemical pharmacology

authors： Horton JK,Thimmaiah KN,Houghton JA,Horowitz ME,Houghton PJ

更新日期：1989-06-01 00:00:00

abstract：:Anandamide and 2-arachidonoylglycerol (2-AG) are two endogenous ligands for the cannabinoid receptors, and their cannabimimetic activities are lost when they are hydrolyzed enzymatically. Cytosol and particulate fractions of porcine brain exhibited a high 2-AG hydrolyzing activity of 100 nmol/min/mg protein. Most of t...

journal_title：Biochemical pharmacology

authors： Goparaju SK,Ueda N,Taniguchi K,Yamamoto S

更新日期：1999-02-15 00:00:00

abstract：:These in vitro studies indicate that N-oxidation of N-hydroxyamphetamine (NOHA) by rat liver homogenates yields phenylacetone oxime (PAOx) as the major metabolite. This oxidation was NADPH and oxygen dependent but was not appreciably increased in microsomes from phenobarbital-pretreated animals. The addition to micros...

journal_title：Biochemical pharmacology

authors： Matsumoto RM,Cho AK

更新日期：1982-01-01 00:00:00

abstract：:Phosphodiesterase inhibitors were used as a tool to manipulate cellular nucleotide levels in vitro and in vivo. The lipopolysaccharide (LPS)-induced release of tumor necrosis factor alpha (TNF-alpha) from mouse peritoneal macrophages was inhibited by prostaglandin E2 with an IC50 of 0.05 microM and by dibutyryl-cAMP w...

journal_title：Biochemical pharmacology

authors： Fischer W,Schudt C,Wendel A

更新日期：1993-06-22 00:00:00

abstract：:Previous studies of platinum(II) compounds with bidentate leaving ligands have emphasized the contrast between the stability of the bidentate leaving ligand in vitro (T1/2 greater than 11 days in water) and the apparent reactivity of these bidentate platinum compounds in vivo. However, none of these studies actually m...

journal_title：Biochemical pharmacology

authors： Mauldin SK,Plescia M,Richard FA,Wyrick SD,Voyksner RD,Chaney SG

更新日期：1988-09-01 00:00:00

abstract：:Hyperactivated macrophages play a key role in the initiation and perpetuation of mucosal inflammation in Crohn's disease (CD). Increasing evidence suggests that the basic helix-loop-helix (bHLH) repressor Twist1 can suppress activation of nuclear factor-κB (NF-κB) and the subsequent production of TNF-α, which are both...

journal_title：Biochemical pharmacology

authors： Tu T,Yu M,Zhang Y,Shi X,Xu J,Hu J,Gan J,He W,Dong L,Han J,Huang Z,Pan Y,Zhang J

更新日期：2018-09-01 00:00:00

abstract：:CYP3A4 is the most important drug-metabolizing enzyme that is involved in biotransformation of more than 50% of drugs. Pregnane X receptor (PXR) dominantly controls CYP3A4 inducibility in the liver, whereas vitamin D receptor (VDR) transactivates CYP3A4 in the intestine by secondary bile acids. Four major functional P...

journal_title：Biochemical pharmacology

authors： Pavek P,Pospechova K,Svecova L,Syrova Z,Stejskalova L,Blazkova J,Dvorak Z,Blahos J

更新日期：2010-01-15 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) cause a range of adverse effects, some of which have been associated with perturbances of lipid metabolic pathways. Previous data demonstrating stereoselective formation of the CoA thioester of R-ibuprofen in particular were suggestive of possible stereoselective effects ...

journal_title：Biochemical pharmacology

authors： Browne GS,Nelson C,Nguyen T,Ellis BA,Day RO,Williams KM

更新日期：1999-04-01 00:00:00

abstract：:Understanding the mechanism of resistance to tubulin-targeted anticancer drugs is important for improved chemotherapy. In this work, a colchicine-resistant MCF-7 cell line (MCF-7Col30) was generated by the gradual increment of colchicine treatment and the MCF-7Col30 showed ∼8-fold resistance towards colchicine. MCF-7C...

journal_title：Biochemical pharmacology

authors： Rai A,Kapoor S,Naaz A,Kumar Santra M,Panda D

更新日期：2017-05-15 00:00:00

abstract：:The glycolipid alpha-galactosylceramide (alpha-GalCer), when presented on CD1 molecules by antigen presenting cells (APCs) to invariant NKT (iNKT cells), is a potent immunomodulator. Indoleamine 2,3-dioxygenase (IDO), an enzyme catalyzing the catabolism of L-tryptophan along the kynurenine pathway, is inducible in APC...

journal_title：Biochemical pharmacology

authors： Fallarini S,Paoletti T,Panza L,Lombardi G

更新日期：2008-09-15 00:00:00

abstract：:This study was designed to assess the participation of transient receptor potential vanilloid 1 (TRPV1) in the biological effects induced by the plant-derived sesquiterpenes polygodial and drimanial. In rat isolated urinary bladder, polygodial and drimanial produced a tachykinin-mediated contraction that was inhibited...

journal_title：Biochemical pharmacology

authors： André E,Campi B,Trevisani M,Ferreira J,Malheiros A,Yunes RA,Calixto JB,Geppetti P

更新日期：2006-04-14 00:00:00

abstract：:Reactive oxygen and nitrogen species are overproduced in the cardiovascular system in response to the exposure to doxorubicin, a cardiotoxic anticancer compound. Oxidant-induced cell injury involves the activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) and pharmacological inhibition of PARP has recen...

journal_title：Biochemical pharmacology

authors： Szenczi O,Kemecsei P,Holthuijsen MF,van Riel NA,van der Vusse GJ,Pacher P,Szabó C,Kollai M,Ligeti L,Ivanics T

更新日期：2005-03-01 00:00:00

abstract：:To investigate the potential interactions between the angiotensin II (Ang II) and insulin signaling systems, regulation of IRS-1 phosphorylation and insulin-induced Akt activation by Ang II were examined in clone 9 (C9) hepatocytes. In these cells, Ang II specifically inhibited activation of insulin-induced Akt Thr(30...

journal_title：Biochemical pharmacology

authors： Arellano-Plancarte A,Hernandez-Aranda J,Catt KJ,Olivares-Reyes JA

更新日期：2010-03-01 00:00:00

abstract：:This study demonstrates that the exposure of phenobarbitone-treated rats to halothane at an oxygen concentration of either 10% or 14% results in marked decreases in cytochrome P-450 content and aminopyrine demethylase activity in animals sacrificed from 1 to 48 hr post-exposure. The alterations observed in the hepatic...

journal_title：Biochemical pharmacology

authors： Knights KM,Gourlay GK,Cousins MJ

更新日期：1987-03-15 00:00:00

abstract：:Dihydromyricetin (DMY) is the most abundant flavonoid in Ampelopsis grossedentata possessing many pharmacological activities. But less is known about its protective effect against nonalcoholic steatohepatitis (NASH) in the context of metabolic syndrome. The present study is aimed to evaluate the pharmacological effect...

journal_title：Biochemical pharmacology

authors： Zeng Y,Hua YQ,Wang W,Zhang H,Xu XL

更新日期：2020-05-01 00:00:00

abstract：:The 3'-fluoro-and 3'-azido-substituted derivatives of 2',3'-dideoxythymidine (ddThd), 2',3'-dideoxyuridine (ddUrd), 2',3'-dideoxy-5-ethyluridine (ddEtUrd) and 2',3'-dideoxycytidine (ddCyd) have been synthesized and evaluated for their anti-retrovirus activity [against human immunodeficiency virus (HIV) and murine Molo...

journal_title：Biochemical pharmacology

authors： Balzarini J,Baba M,Pauwels R,Herdewijn P,De Clerq E

更新日期：1988-07-15 00:00:00

abstract：:The role of calcium in the stimulation of phosphoinositide (PIn) hydrolysis by norepinephrine and the calcium ionophore A23187 was investigated in chopped cerebral cortex in which the PIns had been labeled previously with ([3H]myo-inositol. The accumulation of the newly formed [3H]inositol phosphate ([3H]IPs) was used...

journal_title：Biochemical pharmacology

authors： Knepper SM,Rutledge CO

更新日期：1987-09-15 00:00:00

abstract：:The effect of low M(r) heparin fragments (CY222) and fetal calf serum (FCS) on the level of fibronectin and fibrillar collagen mRNAs was investigated in smooth muscle cells (SMC) in culture. In the absence of FCS, addition of CY222 (100 micrograms/10(6) cells) to postconfluent early passage SMC resulted in a decrease ...

journal_title：Biochemical pharmacology

authors： Asselot-Chapel C,Combacau L,Labat-Robert J,Kern P

更新日期：1995-03-01 00:00:00

abstract：:5,10-Dideazatetrahydrofolic acid (DDATHF) reduces de nova purine biosynthesis by inhibiting glycinamide ribonucleotide transformylase. ICI D1964 and CB3717 are folate-based inhibitors of thymidylate synthase (TS). Fluorodeoxyuridine (FdUrd) following metabolism to FdUMP also inhibits TS. In cultured L1210 cells DDATHF...

journal_title：Biochemical pharmacology

authors： Chong LK,Tattersall MH

更新日期：1995-03-15 00:00:00

abstract：:Nucleoside analogs used in antiviral therapies need to be phosphorylated to their tri-phospho counterparts in order to be active on their cellular target. Human phosphoglycerate kinase (hPGK) was recently reported to participate in the last step of phosphorylation of cytidine L-nucleotide derivatives [Krishnan PGE, La...

journal_title：Biochemical pharmacology

authors： Gallois-Montbrun S,Faraj A,Seclaman E,Sommadossi JP,Deville-Bonne D,Véron M

更新日期：2004-11-01 00:00:00

abstract：:To determine whether alpha,alpha-dideutero substitution in the side chain of the tryptamine molecule can exert primary isotope effects and enhance its bioavailability, equimolar mixtures of tryptamine (T) and either alpha,alpha-dideutero-tryptamine (alpha,alpha-[2H2]T) or beta,beta-dideutero-tryptamine (beta,beta-[2H2...

journal_title：Biochemical pharmacology

authors： Dyck LE,Boulton AA

更新日期：1986-09-01 00:00:00

abstract：:Characteristics of erythromycin binding to Staphylococcus aureus were determined by using kinetics and equilibrium binding experiments. Both methods yielded identical values of the dissociation constant, i.e. 0.1 muM. This value was in accord with that found with a bacterial extract of ribosomes which are the organell...

journal_title：Biochemical pharmacology

authors： Barre J,Fournet MP,Zini R,Deforges L,Duval J,Tillement JP

更新日期：1986-03-15 00:00:00

abstract：:Purification of functional nucleoside transporters has been hampered by the instability of detergent-solubilized proteins. The present study was undertaken to determine if the presence of specific transporter ligands in the solubilization medium could enhance the functional stability of the isolated proteins. Ehrlich ...

journal_title：Biochemical pharmacology

authors： Hammond JR

更新日期：1997-03-07 00:00:00

abstract：:Glutathione transferases are believed to play an important protective role in the various tissues of animals and man by catalysing the glutathione conjugation of electrophilic drugs and electrophilic drug metabolites. Many of these compounds have the potential to react with vital cellular macromolecules in the absence...

journal_title：Biochemical pharmacology

authors： Ahokas JT,Davies C,Ravenscroft PJ,Emmerson BT

更新日期：1984-06-15 00:00:00

abstract：:We investigated the interactions of 4'-(9-acridinylamino)methanesulfon-m-anisidide (mAMSA) with thiol-containing compounds and the potential binding of the thiolytic adducts to DNA. All thiols tested (glutathione, cysteine, coenzyme A, 2-mercaptoethanol and lactate dehydrogenase) formed adducts with mAMSA as evidenced...

journal_title：Biochemical pharmacology

authors： Wong A,Huang CH,Hwang SM,Prestayko AW,Crooke ST

更新日期：1986-05-15 00:00:00

abstract：:Oral administration of tobacco to rats for 21 days caused remarkable stimulation of the metabolism of phenacetin, aniline and benzo[a]pyrene, a carcinogen, by hepatic microsomal mixed function oxidases (MFO). Such treatment for 6 days resulted in a small increase in the activities of phenacetin O-dealkylase and aromat...

journal_title：Biochemical pharmacology

authors： Kaur S,Ali B

更新日期：1982-04-15 00:00:00

abstract：:We have studied the effect of the protein phosphatase (PP) inhibitor, okadaic acid (OKA) on histamine release elicited by immunologic and non-immunologic stimuli in peritoneal and pleural rat mast cells. When cells were stimulated with antigen (egg albumin), OKA strongly inhibited histamine release. This finding sugge...

journal_title：Biochemical pharmacology

authors： Estévez MD,Vieytes MR,Louzao MC,Botana LM

更新日期：1994-02-09 00:00:00