Dietary compounds prevent oxidative damage and nitric oxide production by cells involved in demyelinating disease.

abstract：:The aldo-keto reductases (AKRs) represent a growing oxidoreductase superfamily. Forty proteins have been identified and characterized as AKRs, and an additional fourteen genes may encode proteins related to the superfamily. Found in eukaryotes and prokaryotes, the AKRs metabolize a wide range of substrates, including ...

journal_title：Biochemical pharmacology

authors： Jez JM,Flynn TG,Penning TM

更新日期：1997-09-15 00:00:00

abstract：:Treatment of normolipidemic rats by alkylthiopropionic acid (CETTD), resulted in a dose- and time-dependent increase in total dihydroxyacetone phosphate acyltransferase (DHAPAT) activity, in extent comparable to that of 3-thiadicarboxylic acid (BCMTD) and alkylthioacetic acid (CMTTD). Thus, in CETTD- and CMTTD-treated...

journal_title：Biochemical pharmacology

authors： Skorve J,Ruyter B,Rustan AC,Christiansen EN,Drevon CA,Berge RK

更新日期：1990-11-01 00:00:00

abstract：:Diabetic retinopathy (DR) is the most frequent complication of diabetes and one of leading causes of blindness worldwide. Early phases of DR are characterized by retinal pericyte loss mainly related to concurrent inflammatory process. Recently, an important link between P2X7 receptor (P2X7R) and inflammation has been ...

journal_title：Biochemical pharmacology

authors： Platania CBM,Giurdanella G,Di Paola L,Leggio GM,Drago F,Salomone S,Bucolo C

更新日期：2017-08-15 00:00:00

abstract：:The molecular mechanism(s) underlying induction of the hepatic microsomal cytochrome P4502E1 (2E1) by xenobiotics (e.g. ethanol and acetone) is controversial. Proposed mechanisms include increased rates of enzyme synthesis due to elevated 2E1 mRNA levels, enhanced translation of pre-existing mRNA, or stabilization of ...

journal_title：Biochemical pharmacology

authors： Kraner JC,Lasker JM,Corcoran GB,Ray SD,Raucy JL

更新日期：1993-04-06 00:00:00

abstract：:In the present study the inability of 1,4-benzoquinone to support NADPH-cytochrome reductase catalysed redox cycling was investigated. The results obtained demonstrate that NADPH-cytochrome reductase is able to initiate a rapid two-electron reduction of 1,4-benzoquinone resulting in formation of the hydroquinone. The ...

journal_title：Biochemical pharmacology

authors： Boersma MG,Balvers WG,Boeren S,Vervoort J,Rietjens IM

更新日期：1994-06-01 00:00:00

abstract：:Blood samples from 140 healthy German volunteers were used to further characterize the genetic polymorphism of the human theta class glutathione S-transferase 1 (GSTT1). For measurements of GSTT1 activity, hemolysates were incubated in vitro with different concentrations of dichloromethane. The resulting enzymatically...

journal_title：Biochemical pharmacology

authors： Bruhn C,Brockmöller J,Kerb R,Roots I,Borchert HH

更新日期：1998-11-01 00:00:00

abstract：:In the past few years, substantial advances have been made in analyzing the structure and function of the GABA receptor-gated Cl- channel. A major goal is to identify the molecular characteristics of the GABAA receptor that are necessary for maintaining normal GABAergic neurotransmission. Future studies will undoubted...

journal_title：Biochemical pharmacology

authors： Schwartz RD

更新日期：1988-09-15 00:00:00

abstract：:Reoxygenation of hypoxic (120 min at 37 degrees) rabbit kidney cortical slices in vitro resulted in a rapid increase in lipid peroxidation and phosphatidylinositol hydrolysis. No changes in phosphatidylinositol breakdown occurred during hypoxia or upon reoxygenation in the absence of calcium. Incubation of renal slice...

journal_title：Biochemical pharmacology

authors： Cotterill LA,Gower JD,Clark PK,Fuller BJ,Thorniley MS,Goddard JG,Green CJ

更新日期：1993-05-25 00:00:00

abstract：:Incubation of rat peritoneal mast cells with hydrogen peroxide results in a marked release of histamine. Maximal release is observed with 0.05-0.1 mM H(2)O(2), but higher concentrations of H(2)O(2) instead suppresses the release. Histamine release starts after about 2 min of lag time and reaches a plateau in about 10 ...

journal_title：Biochemical pharmacology

authors： Ohmori H,Yamamoto I,Akagi M,Tasaka K

更新日期：1980-03-01 00:00:00

abstract：:What does it mean to be a mentor in science? Definitions of mentorship are freely spouted in publications and include concepts such as academic support, professional development, role modeling, interaction, impartment of knowledge, evaluation of work, demonstration of methodology, etc. Perhaps most of us would agree w...

journal_title：Biochemical pharmacology

authors： Smith SL

更新日期：2015-11-15 00:00:00

abstract：:Alterations in heme biosynthetic and degradative capabilities and in the activities of several heme-containing enzymes were examined in hepatic tissues of streptozotocin (STZ)-diabetic female Sprague-Dawley rats. Activities were measured 10, 30 and 90 days following the administration of STZ (65 mg/kg, i.v.). The acti...

journal_title：Biochemical pharmacology

authors： Bitar M,Weiner M

更新日期：1983-06-15 00:00:00

abstract：:The aim of this review is to summarize current available information about the role of PI3K/AKT/mTOR signaling in head and neck cancer as a potential target for new therapy options. 90% of all head and neck cancers are squamous cell carcinomas (HNSCC). The most common genetic alteration is inactivation of p16 gene whi...

journal_title：Biochemical pharmacology

authors： Marquard FE,Jücker M

更新日期：2020-02-01 00:00:00

abstract：:The development of an oxidant/antioxidant imbalance in lung inflammation may activate redox-sensitive transcription factors such as nuclear factor-kappa B (NF-kappa B) and activator protein-1 (AP-1), which regulate the genes for proinflammatory mediators and protective antioxidant genes. GSH, a ubiquitous tripeptide t...

journal_title：Biochemical pharmacology

authors： Rahman I

更新日期：2000-10-15 00:00:00

abstract：:We have shown previously that acetaldehyde forms stable covalent adducts with tubulin, resulting in impaired microtubule formation. The present study explored the mechanism responsible for impaired microtubule formation caused by the substoichiometric stable binding of acetaldehyde to tubulin. The free tubulin dimer w...

journal_title：Biochemical pharmacology

authors： Smith SL,Jennett RB,Sorrell MF,Tuma DJ

更新日期：1992-07-07 00:00:00

abstract：:Nitrogen dioxide (NO2), an environmental oxidant pollutant, is known to peroxidize membrane lipids of lung cells. We evaluated the ability of NO2 to alter the surface membrane fluidity, lipid composition, and insulin receptor binding of porcine pulmonary artery endothelial cells in culture. After 3- to 24-hr exposure ...

journal_title：Biochemical pharmacology

authors： Patel JM,Edwards DA,Block ER,Raizada MK

更新日期：1988-04-15 00:00:00

abstract：:The release of the inflammatory mediators, prostaglandins (PGs), leukotrienes (LT) and lysosomal acid hydrolases (LAH), by macrophages is stimulated by endocytic stimuli such as zymosan. This process can be interfered with by specific inhibitors of phosphatidylcholine (PC) biosynthesis. The diphenylsulfone dapsone and...

journal_title：Biochemical pharmacology

authors： Bonney RJ,Wightman PD,Dahlgren ME,Sadowski SJ,Davies P,Jensen N,Lanza T,Humes JL

更新日期：1983-01-15 00:00:00

abstract：:We examined the effects of amiloride derivatives, especially 5-(N-ethyl-N-isopropyl)amiloride (EIPA), on the activity of cytochrome P450 (CYP) 1 isoforms, known to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP), into mutagenic metabolites and whose cellular expression can ...

journal_title：Biochemical pharmacology

authors： Sparfel L,Huc L,Le Vee M,Desille M,Lagadic-Gossmann D,Fardel O

更新日期：2004-05-01 00:00:00

abstract：:The inductive effects of phenobarbitone (PB) and 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) were compared in C57BL/6J mice. Induction parameters included six substrates: ethylmorphine (EM), benzphetamine (Bph), biphenyl, ethoxycoumarin (EtoC), pentoxyresorufin and dichloro-p-nitroanisole (DPNA). In order to ...

journal_title：Biochemical pharmacology

authors： Heubel F,Reuter T,Gerstner E

更新日期：1989-04-15 00:00:00

abstract：:Hyperglycaemia increases the generation of reactive oxidants in blood vessels and is a major cause of endothelial dysfunction. A water-soluble selenium-containing sugar (1,4-Anhydro-4-seleno-d-talitol, SeTal) has potent antioxidant activity in vitro and is a promising treatment to accelerate wound healing in diabetic ...

journal_title：Biochemical pharmacology

authors： Ng HH,Leo CH,O'Sullivan K,Alexander SA,Davies MJ,Schiesser CH,Parry LJ

更新日期：2017-03-15 00:00:00

abstract：:Perfluorodecanoic acid (PFDA) alters the circulating level of thyroid hormones, but the physiological significance of this change at the target tissue remains to be defined. To this end, the activities of thyroid-responsive hepatic enzymes were examined in adult male rats 1 week after treatment with a single dose of P...

journal_title：Biochemical pharmacology

authors： Kelling CK,Van Rafelghem MJ,Menahan LA,Peterson RE

更新日期：1987-04-15 00:00:00

abstract：:The participation of mitochondria in the mechanism of tumor cell death induced by non-steroid anti-inflammatory drugs is uncertain. Here we show that ibuprofen induces death of Walker 256 tumor cells independently on mitochondrial depolarization as estimated by flow cytometry using DioC(6)(3). Oligomycin increased mit...

journal_title：Biochemical pharmacology

authors： Campos CB,Degasperi GR,Pacífico DS,Alberici LC,Carreira RS,Guimarães F,Castilho RF,Vercesi AE

更新日期：2004-12-01 00:00:00

abstract：:Oridonin is a diterpene compound that regulates the activity of PPAR-γ (peroxisome proliferator-activated receptor gamma) transcription factor. Cumulative evidence indicates that AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs) play an important role in the treatment of de...

journal_title：Biochemical pharmacology

authors： Liu P,Du J

更新日期：2020-10-01 00:00:00

abstract：:The present study focused on the desensitization process of the H(2) receptor in U937 cells and the recovery of the cyclic AMP (cAMP) response. Treatment of U937 leukemic cells with the H(2) histamine receptor agonists (+/-)-N(1)-[3-(3, 4-difluorophenyl)-3-(pyridin-2-yl)propyl]-N(2)-[3-(1H-imidazol-4-yl)p ropyl]guanid...

journal_title：Biochemical pharmacology

authors： Lemos Legnazzi B,Shayo C,Monczor F,Martin ME,Fernandez N,Brodsky A,Baldi A,Davio C

更新日期：2000-07-15 00:00:00

abstract：:The antiinflammatory effect of superoxide dismutase was studied in rats with kidney intoxication induced by the injection of nephrotoxic serum. The urinary excretion of protein was increased significantly by the administration of an intravenous injection of nephrotoxic serum. The daily injection of superoxide dismutas...

journal_title：Biochemical pharmacology

authors： Adachi T,Fukuta M,Ito Y,Hirano K,Sugiura M,Sugiura K

更新日期：1986-01-15 00:00:00

abstract：:The seminal vesicle protein No. 4 (SV-IV) secreted from the rat seminal vesicle epithelium, possesses immunosuppressive and anti-inflammatory properties and it is a potent inhibitor of platelet aggregation both in vivo and in vitro. This research aimed to investigate the possible effect of SV-IV on the process of huma...

journal_title：Biochemical pharmacology

authors： Di Micco B,Colonna G,Porta R,Metafora S

更新日期：1994-07-19 00:00:00

abstract：:Substituted fentanyls are abused and cause rapid fatal overdose. As their pharmacology is not well characterized, we examined in vitro pharmacology and structure-activity relationships of 22 substituted fentanyls with modifications of the fentanyl propyl group, and conducted in silico receptor/ligand modeling. Affinit...

journal_title：Biochemical pharmacology

authors： Eshleman AJ,Nagarajan S,Wolfrum KM,Reed JF,Nilsen A,Torralva R,Janowsky A

更新日期：2020-12-01 00:00:00

abstract：:Flunarizine, a calcium (Ca2+)-entry blocker, selective for vascular tissues, inhibits in a concn-dependent way the contraction of isolated rat caudal artery preparations induced by mediators derived from thrombin-stimulated rat platelets. This inhibition is slow in onset and is of prolonged duration. Specific measurem...

journal_title：Biochemical pharmacology

authors： De Clerck F,Van Nueten JM

更新日期：1983-03-01 00:00:00

abstract：:The effect of a choline-deficient diet on microsomal cytochrome P-450 and mixed-function oxidase (MFO) activity was investigated in relation to the development of nutritional cirrhosis. In rats that received the choline-deficient diet for 28 weeks cirrhosis was evident macroscopically and histologically; control rats ...

journal_title：Biochemical pharmacology

authors： Murray M,Zaluzny L,Farrell GC

更新日期：1986-06-01 00:00:00

abstract：:A voluminous number of evidence suggests that an increased consumption of fruit and vegetables is a relatively easy and practical strategy to reduce significantly the incidence of chronic diseases, such as cancer, cardiovascular diseases and other aging-related pathologies. This review will critically discuss the appl...

journal_title：Biochemical pharmacology

authors： Russo GL

更新日期：2007-08-15 00:00:00

abstract：:The O2 dependence of the metabolism of benzylamine to benzaldehyde, benzoate and hippurate was studied in isolated rat hepatocytes. The initial oxidation to benzaldehyde, catalyzed by monoamine oxidase, had an apparent Kmo2 value of 34 microM in cells and 40 microM in isolated rat liver mitochondria. The conversion of...

journal_title：Biochemical pharmacology

authors： Jones DP

更新日期：1984-02-01 00:00:00