Oridonin is an antidepressant molecule working through the PPAR-γ/AMPA receptor signaling pathway.

abstract：:We investigated the interactions of 4'-(9-acridinylamino)methanesulfon-m-anisidide (mAMSA) with thiol-containing compounds and the potential binding of the thiolytic adducts to DNA. All thiols tested (glutathione, cysteine, coenzyme A, 2-mercaptoethanol and lactate dehydrogenase) formed adducts with mAMSA as evidenced...

journal_title：Biochemical pharmacology

authors： Wong A,Huang CH,Hwang SM,Prestayko AW,Crooke ST

更新日期：1986-05-15 00:00:00

abstract：:In this study, we showed that oligogalacturonic acid (OGA) purified from flax pectin inhibit in vitro osteoclastic bone resorption in a dose-dependent manner. The OGA inhibitory effect was neither linked to an effect on osteoclast apoptosis, nor to an inhibition of cathepsin K activity. By means of an in vitro collage...

journal_title：Biochemical pharmacology

authors： Lion JM,Mentaverri R,Rossard S,Jullian N,Courtois B,Courtois J,Brazier M,Mazière JC,Kamel S

更新日期：2009-12-15 00:00:00

abstract：:The reduction of penicillamine disulfide by reductants in aqueous solutions has been studied and compared with that for captopril disulfide. Whereas near quantitative reduction for captopril disulfide was achieved with tributyl phosphine (200 mM), no detectable penicillamine was formed from penicillamine disulfide. Th...

journal_title：Biochemical pharmacology

authors： Drummer OH,Routley L,Christophidis N

更新日期：1987-04-15 00:00:00

abstract：:Common marmosets (Callithrix jacchus) are potentially useful nonhuman primate models for preclinical studies. An anti-inflammatory drug, diclofenac is reportedly metabolized mainly by human cytochrome P450 (P450) 2C9 to 4'-hydroxydiclofenac and minorly by P450 3A4 to 5-hydroxydiclofenac that leads to reactive intermed...

journal_title：Biochemical pharmacology

authors： Nakanishi K,Uehara S,Kusama T,Inoue T,Shimura K,Kamiya Y,Murayama N,Shimizu M,Uno Y,Sasaki E,Yamazaki H

更新日期：2018-06-01 00:00:00

abstract：:MCF-7 human breast cancer cell homogenates and subcellular organelles were submitted to isopycnic centrifugation on Percoll gradients to investigate the subcellular localization of triphenylethylene antiestrogen specific binding sites (AEBS). Electron microscopy revealed that gradient fractions coincident with the mig...

journal_title：Biochemical pharmacology

authors： Gulino A,Vacca A,Modesti A,Screpanti I,Farina A,Frati L

更新日期：1986-11-01 00:00:00

abstract：:PI3K cascade is a central signaling pathway regulating cell proliferation, growth, differentiation, and survival. Tight regulation of the PI3K signaling pathway is necessary to avoid aberrant cell proliferation and cancer development. Together with SHIP-1, the inositol phosphatases PTEN and SHIP-2 are the gatekeepers ...

journal_title：Biochemical pharmacology

authors： Condé C,Gloire G,Piette J

更新日期：2011-11-15 00:00:00

abstract：:Heme oxygenase (HO)-1 is the inducible isoform of the rate-limiting enzyme of heme degradation. HO regulates the cellular content of the pro-oxidant heme and produces catabolites with physiological functions. HO-1 is induced by a host of oxidative stress stimuli, and the activation of HO-1 gene expression is considere...

journal_title：Biochemical pharmacology

authors： Immenschuh S,Ramadori G

更新日期：2000-10-15 00:00:00

abstract：:Novel hydroxynaphthoquinones have been shown to be potent and selective inhibitors of mitochondrial electron transport in the protozoan Eimeria tenella, inhibiting at concentrations of 10(-10) to 10(-11)M. The primary site of electron transport inhibition has been localized to the ubiquinol-cytochrome c reductase span...

journal_title：Biochemical pharmacology

authors： Fry M,Hudson AT,Randall AW,Williams RB

更新日期：1984-07-01 00:00:00

abstract：:It has been reported that endothelins (ETs) stimulate catecholamine release from chromaffin cells. However, it is not known whether ETs also affect catecholamine biosynthesis. Thus, using a rat pheochromocytoma cell line, PC12, we examined the effects of ETs on catecholamine biosynthesis. The mRNA level and activity o...

journal_title：Biochemical pharmacology

authors： Takekoshi K,Ishii K,Shibuya S,Kawakami Y,Isobe K,Nakai T

更新日期：2002-03-01 00:00:00

abstract：:Alzheimer disease (AD) is a progressive neurodegenerative disorder characterized by severe cognitive impairment, inability to perform activities of daily living and mood changes. Statins, long known to be beneficial in conditions where dyslipidemia occurs by lowering serum cholesterol levels, also have been proposed f...

journal_title：Biochemical pharmacology

authors： Barone E,Di Domenico F,Butterfield DA

更新日期：2014-04-15 00:00:00

abstract：:Silymarin is known to have hepatoprotective and anticarcinogenic effects. Recently, anti-inflammatory effect of silymarin is attracting an increasing attention, but the mechanism of this effect is not fully understood. Here, we report that silymarin protected mice against lipopolysaccharide (LPS)-induced sepsis. In th...

journal_title：Biochemical pharmacology

authors： Kang JS,Jeon YJ,Park SK,Yang KH,Kim HM

更新日期：2004-01-01 00:00:00

abstract：:Microsomal and cytosolic epoxide hydrolase (mEH and cEH respectively) and glutathione S-transferase (GST) activities were measured in the liver, kidney, and gills of rainbow trout. Assays were optimized for time, pH, and temperature, using trans-stilbene oxide (TSO) and cis-stilbene oxide (CSO) as substrates for cEH a...

journal_title：Biochemical pharmacology

authors： Laurén DJ,Halarnkar PP,Hammcock BD,Hinton DE

更新日期：1989-03-15 00:00:00

abstract：:The aim of this study was to determine the culture conditions that could modulate the induction of apoptosis by all-trans retinoic acid (ATRA). Cell viability was evaluated by trypan blue test, differentiation by nitro blue tetrazolium test, and apoptosis by morphological analysis. ATRA induced apoptosis in HL60 cells...

journal_title：Biochemical pharmacology

authors： Carpentier Y,Mayer P,Bobichon H,Desoize B

更新日期：1998-01-15 00:00:00

abstract：:The reactivities of sulfite (SO23-) with DNA in the presence of metal ions were investigated by a DNA sequencing technique using 32P-labeled DNA fragments obtained from human c-Ha-ras-1 protooncogene. Sulfite caused DNA damage in the presence of Co2+, Cu2+ and Mn2+, although sulfite alone or metal ion alone did not. T...

journal_title：Biochemical pharmacology

authors： Kawanishi S,Yamamoto K,Inoue S

更新日期：1989-10-15 00:00:00

abstract：:Cancer develops through a series of genetic changes leading to malignant transformation. Numerous gene and pathways involved in stages of progression to frank malignancy have been elucidated. These genetic changes result in aberrations in fundamental cellular processes controlling proliferation, apoptosis, differentia...

journal_title：Biochemical pharmacology

authors： Pinkas J,Teicher BA

更新日期：2006-08-28 00:00:00

abstract：:Nuclear factor-kappaB (NF-kappaB) activity affects cell survival and determines the sensitivity of cancer cells to cytotoxic agents as well as to ionizing radiation. Preventing the protective function of NF-kappaB may result in chemo- and radio-sensitization of cancer cells. Therefore, NF-kappaB has emerged as one of ...

journal_title：Biochemical pharmacology

authors： Waddick KG,Uckun FM

更新日期：1999-01-01 00:00:00

abstract：:A large variety of 5-substituted 2'deoxyuridines (dUrds) and 2'-deoxyuridylates (dUMPs) have been evaluated for their inhibitory effects on the thymidine (dThd) kinase or thymidylate (dTMP) synthetase isolated from mouse leukemia L1210 cells. The most potent inhibitors of dThd kinase were 5-chloro-, 5-bromo- and 5-iod...

journal_title：Biochemical pharmacology

authors： Balzarini J,De Clercq E,Mertes MP,Shugar D,Torrence PF

更新日期：1982-11-15 00:00:00

abstract：:Calmodulin can be specifically acylated with a fluorene-containing hydrophobic spin-labeling reagent at just Lys 75 or at Lys 75 and Lys 148. The binding of trifluoperazine to calmodulin and the two adducts was determined using a Hummel-Dreyer procedure, and binding of the phenothiazine was found to be characterized b...

journal_title：Biochemical pharmacology

authors： Jackson AE,Puett D

更新日期：1986-12-15 00:00:00

abstract：BACKGROUND:Rho-Associated kinases ROCK1 and ROCK2 have been extensively investigated in the pathogenesis of cardiovascular disease. However, their roles are not fully understood in carcinogenesis. In this study, we investigated whether ROCK1 or ROCK2 is required for the survival and growth of hepatocellular carcinoma (...

journal_title：Biochemical pharmacology

authors： Wu H,Chen Y,Li B,Li C,Guo J,You J,Hu X,Kuang D,Qi S,Liu P,Li L,Xu C

更新日期：2020-12-02 00:00:00

abstract：:The interaction of various cholecystokinin (CCK) peptides with the protein inhibitor (PK-I) of cyclic AMP dependent protein kinase (A-PK) has been studied. The order of the affinities (ED50) for relaxation of hog biliary muscle by a series of C-terminal peptides of CCK correlated with the order of the potencies for A-...

journal_title：Biochemical pharmacology

authors： Kimura M,Kobayashi S,Kimura I

更新日期：1983-03-01 00:00:00

abstract：:The effects of three phenothiazines, promethazine, thiazinamium chloride and chlorpromazine, on macrophage function were investigated in rat alveolar macrophages. The study focused on thromboxane B2 (TxB2) synthesis, zymosan phagocytosis, and hexosemonophosphate (HMP) shunt activity in these phagocytes. TxB2 synthesis...

journal_title：Biochemical pharmacology

authors： Chang J,Piperata S,Skowronek M,Lewis AJ

更新日期：1983-09-15 00:00:00

abstract：:The inactive anthracycline analog 4-demethoxy-7,9-di-epi-daunorubicin was covalently coupled to polyglutaraldehyde microspheres. The polymer-bound analog acquired significant cytostatic activity as evaluated with doxorubicin resistant and sensitive murine L1210 leukemia cells. A suggested multiple membrane interaction...

journal_title：Biochemical pharmacology

authors： Rogers KE,Tökés ZA

更新日期：1984-02-15 00:00:00

abstract：:Sex differences in the diabetes-induced changes in hepatic cytochrome P450 proteins were investigated in rats treated with streptozotocin. Changes in specific cytochrome P450 proteins were monitored using diagnostic substrates and immunologically utilizing specific polyclonal antibodies. When expressed in terms of nmo...

journal_title：Biochemical pharmacology

authors： Barnett CR,Rudd S,Flatt PR,Ioannides C

更新日期：1993-01-26 00:00:00

abstract：:In model experiments using human erythrocytes, glycochenodeoxycholate caused extensive membrane damage (as judged by release of membrane phospholipid and acetylcholinesterase and by cell lysis) at approximately 10-fold lower concentrations than glycocholate. Chenodeoxycholate feeding had no effect upon the total prote...

journal_title：Biochemical pharmacology

authors： Rahman K,Billington D

更新日期：1984-07-15 00:00:00

abstract：:Antitubulin activities of ansamitocins, maytansine and four maytansinoids which are structurally related to ansamitocins were studied using three reaction systems; inhibition of polymerization of bovine brain tubulin, depolymerization of the once polymerized tubulin, and immunofluorescent staining of cytoplasmic micro...

journal_title：Biochemical pharmacology

authors： Ikeyama S,Takeuchi M

更新日期：1981-09-01 00:00:00

abstract：:When HL-60 cells were stimulated with histamine, a significant differentiation of the cells toward neutrophils was elicited. Histamine increased phagocytic activity, but it reduced myeloperoxidase activity of HL-60 cells. Histamine-induced differentiation in HL-60 cells was inhibited not only by H2 antagonists, such a...

journal_title：Biochemical pharmacology

authors： Nonaka T,Mio M,Doi M,Tasaka K

更新日期：1992-09-25 00:00:00

abstract：:The human P2Y₁₁ nucleotide receptor mRNA was found in virtually all human tissues, and the receptor serves many physiological roles, such as immune response regulation. The Ala-87-Thr-P2Y₁₁ receptor single nucleotide polymorphism was linked to increased risk for acute myocardial infarction. To facilitate the developme...

journal_title：Biochemical pharmacology

authors： Haas M,Ben-Moshe I,Fischer B,Reiser G

更新日期：2013-09-01 00:00:00

abstract：:Interleukin-2 (IL-2) has been shown to decrease cytochrome P450 (CYP) mRNAs and proteins in cultured rat hepatocytes, and IL-2 administration decreases CYPs in rats. Although high doses of IL-2 are administered to cancer patients, the effect on human CYPs has not yet been determined. Patients with hepatic metastases f...

journal_title：Biochemical pharmacology

authors： Elkahwaji J,Robin MA,Berson A,Tinel M,Lettéron P,Labbe G,Beaune P,Elias D,Rougier P,Escudier B,Duvillard P,Pessayre D

更新日期：1999-04-15 00:00:00

abstract：:The peripheral benzodiazepine receptor (PBR), an integral protein of the mitochondrial membrane, is involved in the formation of mitochondrial permeability transition (MPT) pores. The opening of the MPT-leading to the dissipation of the inner-mitochondrial transmembrane potential (deltapsi(m))-is considered to be an e...

journal_title：Biochemical pharmacology

authors： Strohmeier R,Roller M,Sänger N,Knecht R,Kuhl H

更新日期：2002-07-01 00:00:00

abstract：:Caco-2 cells are a widely used model in drug development to study intestinal drug transport and metabolism. Recently, serotonin (5-hydroxytryptamine, 5-HT) has been characterized as a highly selective substrate of human UDP-glucuronosyltransferase UGT1A6 [Krishnaswamy S, Duan SX, von Moltke LL, Greenblatt DJ, Court MH...

journal_title：Biochemical pharmacology

authors： Köhle C,Badary OA,Nill K,Bock-Hennig BS,Bock KW

更新日期：2005-05-01 00:00:00