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Statins more than cholesterol lowering agents in Alzheimer disease: their pleiotropic functions as potential therapeutic targets.

Abstract：

:Alzheimer disease (AD) is a progressive neurodegenerative disorder characterized by severe cognitive impairment, inability to perform activities of daily living and mood changes. Statins, long known to be beneficial in conditions where dyslipidemia occurs by lowering serum cholesterol levels, also have been proposed for use in neurodegenerative conditions, including AD. However, it is not clear that the purported effectiveness of statins in neurodegenerative disorders is directly related to cholesterol-lowering effects of these agents; rather, the pleiotropic functions of statins likely play critical roles. The aim of this review is to provide an overview on the new discoveries about the effects of statin therapy on the oxidative and nitrosative stress levels as well as on the modulation of the heme oxygenase/biliverdin reductase (HO/BVR) system in the brain. We propose a novel mechanism of action for atorvastatin which, through the activation of HO/BVR-A system, may contribute to the neuroprotective effects thus suggesting a potential therapeutic role in AD and potentially accounting for the observation of decreased AD incidence with persons on statin.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Barone E,Di Domenico F,Butterfield DA

doi

10.1016/j.bcp.2013.10.030

subject

Has Abstract

pub_date

2014-04-15 00:00:00

pages

605-16

issue

4

eissn

0006-2952

issn

1873-2968

pii

S0006-2952(13)00714-4

journal_volume

88

pub_type

杂志文章,评审

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