Abstract:
:The action of nystatin, a polyene antibiotic, was studied in rat myocardial cells, isolated rat hearts, and intact rats. Myocardial cells responded to 10 and 25 micrograms nystatin/ml with arrhythmias that could be minimized by elevated concentrations of K+ and Mg2+ or reversed by washing the cells. Similarly, the isolated heart responded to 100 micrograms nystatin/ml with arrhythmias that could be tempered by addition of elevated concentrations of K+ and Mg2+. The i.v. injection of the drug caused heart failure in intact animals at the 4-mg/kg dose level. At the subcellular level, nystatin made the myocardial cell membranes more rigid, as measured by electron spin resonance spectrometry. These findings indicate a parallel between physiocochemical changes caused by nystatin in the myocardial cell membrane and the biological changes caused by this drug in myocardial cells, isolated heart, and heart of the intact animal.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Aszalos A,Bradlaw JA,Reynaldo EF,Yang GC,El-Hage ANdoi
10.1016/0006-2952(84)90040-6subject
Has Abstractpub_date
1984-12-01 00:00:00pages
3779-86issue
23eissn
0006-2952issn
1873-2968pii
0006-2952(84)90040-6journal_volume
33pub_type
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