Abstract：
:In artificially ventilated beagle dogs a severe hypoglycemic condition was induced by insulin injection, while the posthypoglycemic recovery was induced by glucose treatment at the end of a 20-min period of spontaneous electroencephalographic silence. The motor area of the cerebral cortex was analyzed for glycolytic metabolites, related amino acids, energy mediators, fatty acids, phospholipids and free fatty acids. The effects on the posthypoglycemic recovery of a intracarotid infusion with some agents (i.e. uridine, cytidine, DL-carnitine, DL-acetylcarnitine, papaverine) were tested. Severe hypoglycemia induced an extensive derangement of the brain metabolism, with partial restitution during the posthypoglycemic recovery. During this condition, the intracarotid perfusion with some biological pyrimidines (uridine, cytidine) interfered with the glycolytic and amino acid metabolites, inducing a decrease in glucose, pyruvate and lactate contents, and an increase in succinate, alanine and glutamine cerebral concns. The lipid carriers (DL-carnitine, DL-acetylcarnitine) interfered with the fatty acid degradation inducing a magnification of the decrease in the individual (palmitic acid, oleic acid) and total fatty acids, the vasodilating agent (papaverine) being practically inactive.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Benzi G,Gorini A,Dossena M,Taglietti M,Fulle D,Pastoris Odoi
10.1016/0006-2952(83)90629-9subject
Has Abstractpub_date
1983-03-15 00:00:00pages
1083-91issue
6eissn
0006-2952issn
1873-2968pii
0006-2952(83)90629-9journal_volume
32pub_type
杂志文章abstract：:In the present study, a novel synthetic compound 4-(2-(cyclohex-2-enylidene)hydrazinyl)quinolin-2(1H)-one (CYL-4d) was found to inhibit lipopolysaccharide (LPS)-induced nitric oxide (NO) production without affecting cell viability or enzyme activity of expressed inducible NO synthase (iNOS) in RAW 264.7 macrophages. C...
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
doi：10.1016/0006-2952(85)90189-3
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：1988-10-01 00:00:00
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更新日期：2013-09-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.bcp.2005.07.034
更新日期：2005-10-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.bcp.2006.08.001
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pub_type： 杂志文章
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更新日期：2003-05-15 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.bcp.2016.09.011
更新日期：2016-11-15 00:00:00
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pub_type： 杂志文章,评审
doi：10.1016/s0006-2952(98)00245-7
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
doi：10.1016/0006-2952(96)00348-6
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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更新日期：2015-03-15 00:00:00
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journal_title：Biochemical pharmacology
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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更新日期：2008-01-15 00:00:00
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pub_type： 杂志文章
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更新日期：1992-06-09 00:00:00
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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更新日期：1986-02-15 00:00:00
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
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更新日期：2009-11-01 00:00:00
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
doi：10.1016/0006-2952(91)90112-i
更新日期：1991-05-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-12-01 00:00:00
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
doi：10.1016/j.bcp.2014.07.013
更新日期：2014-10-01 00:00:00
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journal_title：Biochemical pharmacology
pub_type： 杂志文章
doi：10.1016/0006-2952(91)90651-k
更新日期：1991-04-15 00:00:00
