Abstract:
:Pentahydroxyflavone dihydrate, quercetin (QU) is one of common flavonols biosynthesized by plants and has been suggested to modulate inflammatory responses in various models. In the present study, we investigated in vivo effects of oral or intra-cutaneous QU in chronic rat adjuvant-induced arthritis (AA). Growth delay and arthritic scores were evaluated daily after AA induction in Lewis rats. Oral administration of QU (5 x 160 mg/kg) to arthritic rats resulted in a clear decrease of clinical signs compared to untreated controls. Intra-cutaneous injections of lower doses (5 x 60 mg/kg) of QU gave similar anti-arthritic effects, while 5 x 30 mg/kg concentrations were inefficient in this respect. Finally, injection of relatively low QU doses (5 x 30 mg/kg) prior to AA induction significantly reduced arthritis signs. As QU was suggested to inhibit macrophage-derived cytokines and nitric oxide (NO), we then analyzed macrophage response ex vivo. Anti-arthritic effects of QU correlated with significant decrease of inflammatory mediators produced by peritoneal macrophages, ex vivo and in vitro. These data indicate that QU is a potential anti-inflammatory therapeutic and preventive agent targeting the inflammatory response of macrophages.
journal_name
Biochem Pharmacoljournal_title
Biochemical pharmacologyauthors
Mamani-Matsuda M,Kauss T,Al-Kharrat A,Rambert J,Fawaz F,Thiolat D,Moynet D,Coves S,Malvy D,Mossalayi MDdoi
10.1016/j.bcp.2006.08.001subject
Has Abstractpub_date
2006-11-15 00:00:00pages
1304-10issue
10eissn
0006-2952issn
1873-2968pii
S0006-2952(06)00496-5journal_volume
72pub_type
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