The GABAA receptor-gated ion channel: biochemical and pharmacological studies of structure and function.

Abstract:

:In the past few years, substantial advances have been made in analyzing the structure and function of the GABA receptor-gated Cl- channel. A major goal is to identify the molecular characteristics of the GABAA receptor that are necessary for maintaining normal GABAergic neurotransmission. Future studies will undoubtedly include techniques that have been used successfully to construct a detailed structural and dynamic model of the nACHR-gated ion channel. These include X-ray scattering, single group rotation theory, and genetic homology, deletion and site-directed mutation studies. Such techniques will make it possible to identify the structural defects that give rise to abnormal GABA receptor function and possibly to sleep, anxiety and seizure disorders.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Schwartz RD

doi

10.1016/0006-2952(88)90684-3

subject

Has Abstract

pub_date

1988-09-15 00:00:00

pages

3369-75

issue

18

eissn

0006-2952

issn

1873-2968

pii

0006-2952(88)90684-3

journal_volume

37

pub_type

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