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Potentiating effects of clofibrate on prostaglandin-dependent and -independent pathways of human platelet activation: evidence for involvement of cyclic AMP.

Abstract：

:Although clofibrate has been shown to inhibit platelet aggregation that is caused by thrombin, ADP and epinephrine, by blocking the release of arachidonic acid from platelet phospholipids [8], here we have demonstrated that clofibrate enhanced platelet aggregation by arachidonic acid and PLC and reversed the effects of PGE1 on platelet cAMP concentration and on PLC-induced secretion of [14C]-5HT in similar, concentration-dependent manners. Taken together, these findings strongly suggest that the proaggregatory effect of clofibrate is mediated by a lowering of cAMP in platelets.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Huzoor-Akbar,Witiak DT,Newman HA,Fertel RH,Feller DR

doi

10.1016/0006-2952(82)90434-8

subject

Has Abstract

pub_date

1982-06-01 00:00:00

pages

2125-8

issue

11

eissn

0006-2952

issn

1873-2968

pii

0006-2952(82)90434-8

journal_volume

31

pub_type

杂志文章

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