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Comparison of the ability of dopamine receptor agonists to inhibit forskolin-stimulated adenosine 3'5'-cyclic monophosphate (cAMP) accumulation via D2L (long isoform) and D3 receptors expressed in Chinese hamster ovary (CHO) cells.

Abstract：

:The pharmacological properties of the human D2L (long isoform) and rat D3 dopamine receptors in functional assays were examined. A range of dopamine agonists were assessed for their ability to inhibit adenosine 3'5'-cyclic monophosphate (cAMP) accumulation via the two receptors expressed stably in Chinese hamster ovary cells. Dopamine caused a significantly greater maximal inhibition (P < 0.05) of cAMP accumulation via the D2L receptor (approximately 70%) as compared to the D3 receptor (approximately 50%). The pattern of agonist effects was different at the two receptors. The absolute and relative potencies for inhibition of cAMP accumulation were different for a range of agonists acting at the two receptors. Similarly, the maximal inhibitions achieved by a range of agonists were different for the two receptors.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Hall DA,Strange PG

doi

10.1016/s0006-2952(99)00101-x

subject

Has Abstract

pub_date

1999-07-15 00:00:00

pages

285-9

issue

2

eissn

0006-2952

issn

1873-2968

pii

S0006-2952(99)00101-X

journal_volume

58

pub_type

杂志文章

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