Influence of delta 9-tetrahydrocannabinol on expression of histone and ribosomal genes in normal and transformed human cells.

Abstract:

:The influence of delta 9-tetrahydrocannabinol (delta 9-THC) on the cellular levels of histone mRNAs and ribosomal RNAs was examined in several normal and transformed human cell lines--HeLa S3 cells, WI-38 human diploid fibroblasts, SV40-transformed WI-38 cells, and A549 lung carcinoma cells. RNA sequences were quantitatively assayed by electrophoretic fractionation, transfer to nitrocellulose, and hybridization with cloned genomic human histone or ribosomal DNA sequences. Treatment with delta 9-THC (10-40 microM) for 10 hr resulted in a concentration-dependent decrease in the representation of H2A, H2B, H3 and H4 histone mRNAs without a significant inhibitory effect on the levels of ribosomal RNAs. The cannabinoid-mediated inhibitory effect on histone gene expression was less evident in cells with active drug-metabolizing systems.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Green LG,Stein JL,Stein GS

doi

10.1016/0006-2952(84)90510-0

subject

Has Abstract

pub_date

1984-04-01 00:00:00

pages

1033-40

issue

7

eissn

0006-2952

issn

1873-2968

pii

0006-2952(84)90510-0

journal_volume

33

pub_type

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