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Similar pyruvate kinase modifications in glioblastoma cells by 7β-hydroxycholesterol and glutamine withdrawal.

Abstract：

:Oxysterols possess anti-proliferative properties that may be used with much effect in the treatment of cancer. We have demonstrated previously that 7 beta-hydroxycholesterol (7b-HC) provokes both metabolic stress, as witnessed by AMPK activation, and changes in lipid raft composition in C6 glioblastoma cells. These observations suggested that glycolysis might have been changed. Here we will show that 7b-HC increases cell cycle time and that it changes the affinity of pyruvate kinase to its substrate, phosphoenol pyruvate. The latter effect is mimicked by glutamine withdrawal.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

de Weille J,Fabre C,Gaven C,Bakalara N

doi

10.1016/j.bcp.2013.03.012

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

161-7

issue

1

eissn

0006-2952

issn

1873-2968

pii

S0006-2952(13)00193-7

journal_volume

86

pub_type

杂志文章

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