Polyunsaturated fatty acids reduce pyrogen-induced tissue factor expression in human monocytes.

abstract：:Using a continuous perfusion system, synaptosomes prepared from rat brain released [3H]norepinephrine in a Ca2+-dependent manner when pulse depolarized by briefly elevating external potassium concentrations. Tetrodotoxin (10(-7) M), a sodium channel blocker, inhibited 48% of this pulsed release, and D595 (10(-5) M), a...

journal_title：Biochemical pharmacology

authors： Clark JM,Brooks MW

更新日期：1989-07-15 00:00:00

abstract：:Cannabidiol (CBD) has been shown to inhibit mouse hepatic mixed-function oxidations of several drugs after acute treatment, whereas repetitive treatment resulted in the restoration of drug-metabolizing capabilities. We have found that acute CBD treatment modestly decreased cytochrome P-450 content but markedly decreas...

journal_title：Biochemical pharmacology

authors： Bornheim LM,Correia MA

更新日期：1989-09-01 00:00:00

abstract：:SARM is the fifth and most conserved member of the Toll/Il-1 Receptor (TIR) adaptor family. However, unlike the other TIR adaptors, MyD88, Mal, TRIF and TRAM, SARM does not participate in transducing signals downstream of TLRs. By contrast SARM inhibits TLR signalling by interacting with the adaptors TRIF and MyD88. I...

journal_title：Biochemical pharmacology

authors： Carty M,Bowie AG

更新日期：2019-03-01 00:00:00

abstract：:[3H]Morphine, PL-017[prolyl-3,4-3H,D-prolyl,3,4-3H] ([3H]PL-017) and enkephalin-(2-D-penicillamine,5-D-penicillamine)[tyrosyl-2,6-3H] ([3H]DPDPE) were directly cross-linked to mouse brain opiate receptors by an ultraviolet (254 nm) irradiation procedure. [3H]Morphine preferentially and specifically labeled a 58 kDa pr...

journal_title：Biochemical pharmacology

authors： Nagamatsu K,Tagawa Y,Uchida S,Hasegawa A

更新日期：1993-10-05 00:00:00

abstract：:The 5-HT1A receptor is a critical mediator of serotonergic (5-HT) function. We have identified 13 potential single nucleotide polymorphisms resulting in amino acid changes throughout the human 5-HT1A receptor. The pharmacological profiles of these 13 polymorphic variants were then characterized using a high-throughput...

journal_title：Biochemical pharmacology

authors： Del Tredici AL,Schiffer HH,Burstein ES,Lameh J,Mohell N,Hacksell U,Brann MR,Weiner DM

更新日期：2004-02-01 00:00:00

abstract：:We investigated the effects of tranilast on inducible cyclooxygenase (COX2)-mediated prostaglandin E2 (PGE2) production and enzyme induction in interleukin-lbeta (IL-1beta)-stimulated cultured dermal fibroblasts. IL-1beta enhanced PGE2 production in cultured fibroblasts. Tranilast did not affect constitutive cyclooxyg...

journal_title：Biochemical pharmacology

authors： Inoue H,Ohshima H,Kono H,Yamanaka M,Kubota T,Aihara M,Hiroi T,Yago N,Ishida H

更新日期：1997-06-15 00:00:00

abstract：:The nitroderivative 1-nitro-2-phenylethane (NPE) was recently described as a compound possessing heme-dependent soluble guanylyl cyclase (sGC) stimulating properties in vascular smooth muscle cells. In this study, we tested such pharmacological property of NPE in mice pancreatic acinar cells subjected to the bile salt...

journal_title：Biochemical pharmacology

authors： Cosker F,Lima FJ,Lahlou S,Magalhães PJ

更新日期：2014-09-15 00:00:00

abstract：:C-1748 is a DNA-binding agent with potent antitumor activity, especially towards prostate and colon carcinoma xenografts in mice. Here, we elucidated the nature of cellular response of human colon carcinoma HCT8 and HT29 cells to C-1748 treatment, at biologically relevant concentrations (EC(90) and their multiplicity)...

journal_title：Biochemical pharmacology

authors： Augustin E,Moś-Rompa A,Nowak-Ziatyk D,Konopa J

更新日期：2010-05-01 00:00:00

abstract：:We studied several steps of methionine metabolism in isolated rat hepatocytes both with and without the presence of a hepatotoxic agent (D-galactosamine). By use of selective labelling either on methyl or on carboxyl groups, we showed that intracellular methionine is used preferentially for the methylation of phosphol...

journal_title：Biochemical pharmacology

authors： Ozturk M,Lemonnier F,Cresteil D,Lemonnier A

更新日期：1986-12-01 00:00:00

abstract：:Free radical-induced damage to lipid and protein constituents of neuronal membranes contributes to the pathophysiology of neurodegenerative diseases, including Alzheimer's disease (AD). The development of an effective inhibitor of oxidative stress represents an important goal for the treatment of AD. In this study, th...

journal_title：Biochemical pharmacology

authors： Mason RP,Olmstead EG,Jacob RF

更新日期：2000-09-01 00:00:00

abstract：:We have investigated whether or not the cellular content of reactive platinum, aside from total cellular and DNA-bound platinum, is a measure of the growth inhibitory potential of a given platinum complex. Human MCF-7 breast cancer cells, after treatment with cisplatin [cis-diamminedichloroplatinum(II)] and several 1,...

journal_title：Biochemical pharmacology

authors： Lindauer E,Holler E

更新日期：1996-07-12 00:00:00

abstract：:Breast cancer is the most prevalent type of tumor and the second leading cause of death due to cancer among women. Although screening methods, diagnosis and therapeutic options have improved in the last decade, chemoresistance remains an important challenge. There is evidence relating breast cancer resistance with sig...

journal_title：Biochemical pharmacology

authors： Muley H,Fadó R,Rodríguez-Rodríguez R,Casals N

更新日期：2020-07-01 00:00:00

abstract：:Catalase is an antioxidant enzyme that catalyzes mainly the transformation of hydrogen peroxide into water and oxygen. Although catalase is frequently down-regulated in tumors the underlying mechanism remains unclear. Few transcription factors have been reported to directly bind the human catalase promoter. Among them...

journal_title：Biochemical pharmacology

authors： Glorieux C,Auquier J,Dejeans N,Sid B,Demoulin JB,Bertrand L,Verrax J,Calderon PB

更新日期：2014-05-15 00:00:00

abstract：:We examined the effects of amiloride derivatives, especially 5-(N-ethyl-N-isopropyl)amiloride (EIPA), on the activity of cytochrome P450 (CYP) 1 isoforms, known to metabolize carcinogenic polycyclic aromatic hydrocarbons (PAHs), such as benzo(a)pyrene (BP), into mutagenic metabolites and whose cellular expression can ...

journal_title：Biochemical pharmacology

authors： Sparfel L,Huc L,Le Vee M,Desille M,Lagadic-Gossmann D,Fardel O

更新日期：2004-05-01 00:00:00

abstract：:The anti-anginal agent bepridil blocks slow Ca2+ channels in a variety of tissues. Since bepridil accumulates inside cells, the possibility exists that bepridil acts, at least partially, from inside the cell. To test this possibility, we examined the effects of a quaternary ammonium analog of bepridil, methylated bepr...

journal_title：Biochemical pharmacology

authors： Wahler GM,Doane JD,Ousterhout JM,Sperelakis N,Lamar JC,Busch N,Biswas JC,Rogers TB

更新日期：1986-07-15 00:00:00

abstract：:The role of calcium in the stimulation of phosphoinositide (PIn) hydrolysis by norepinephrine and the calcium ionophore A23187 was investigated in chopped cerebral cortex in which the PIns had been labeled previously with ([3H]myo-inositol. The accumulation of the newly formed [3H]inositol phosphate ([3H]IPs) was used...

journal_title：Biochemical pharmacology

authors： Knepper SM,Rutledge CO

更新日期：1987-09-15 00:00:00

abstract：:Recently, we reported that alterations in topoisomerase II (topo II) activity appear to contribute to mitomycin C (MMC) resistance in HT-29R13 human colon cancer cells under aerobic conditions. In this study, the expression of topo II alpha and topo II beta in parent HT-29 and MMC resistant variant HT-29R13 cells was ...

journal_title：Biochemical pharmacology

authors： Kang Y,Greaves B,Perry RR

更新日期：1996-08-23 00:00:00

abstract：:The advent of drugs targeting tumor-associated prosurvival alterations of cancer cells has changed the interest of antitumor drug development from cytotoxic drugs to target-specific agents. Although single-agent therapy with molecularly targeted agents has shown limited success in tumor growth control, a promising str...

journal_title：Biochemical pharmacology

authors： Perego P,Cossa G,Zuco V,Zunino F

更新日期：2010-11-15 00:00:00

abstract：:Incubation of cultured embryonic chicken heart cells with transforming growth factor beta 1 (TGF-beta 1) resulted in a concentration- and time-dependent decrease in the number of muscarinic acetylcholine receptors (mAChR), which reached a maximum by 24 hr. Twenty-four hours following TGF-beta 1 treatment, cm2 and cm4 ...

journal_title：Biochemical pharmacology

authors： Jackson DA,Nathanson NM

更新日期：1997-08-15 00:00:00

abstract：:We investigated the amplification of bleomycin-induced DNA cleavage by synthetic triamides containing N-methylpyrrole (Py) and/or N-methylimidazole (Im), PyPyPy, PyPyIm, PyImPy, and PyImIm, using 32P-labeled DNA fragments obtained from the human c-Ha-ras-1 and p53 genes. Peplomycin, a bleomycin analog, plus Fe(II) cau...

journal_title：Biochemical pharmacology

authors： Hiraku Y,Oikawa S,Kuroki K,Sugiyama H,Saito I,Kawanishi S

更新日期：2001-02-01 00:00:00

abstract：:To investigate the hypothesis that cyclic AMP (cAMP) regulates arachidonic acid metabolism in vascular tissue, we have studied the effects of forskolin (FSK), an activator of adenylate cyclase, and 3-isobutyl-1-methylxanthine (IBMX), a phosphodiesterase inhibitor, on hormone-stimulated prostacyclin (PGI2) synthesis in...

journal_title：Biochemical pharmacology

authors： Whorton AR,Collawn JB,Montgomery ME,Young SL,Kent RS

更新日期：1985-01-01 00:00:00

abstract：:The TRPM8 cation channel can be activated by the cooling compound icilin. Recently, we showed that stimulation of TRPM8 channels induces a signaling cascade leading to the activation of the transcription factor AP-1. Additionally, expression of the AP-1 constituent c-Fos has been shown to be induced following TRPM8 st...

journal_title：Biochemical pharmacology

authors： Ulrich M,Wissenbach U,Thiel G

更新日期：2020-07-01 00:00:00

abstract：:Theophylline, caffeine, isobutylmethylxanthine, papaverine, N6-cyclohexyladenosine, N6-allyl-N6-cyclohexyladenosine ( ACHA ) and N6-L-phenylisopropyladenosine (L-PIA) inhibited the transport of adenosine, uridine and hypoxanthine in Novikoff rat hepatoma cells. The IC50 values for the inhibition of uridine transport r...

journal_title：Biochemical pharmacology

authors： Plagemann PG,Wohlhueter RM

更新日期：1984-06-01 00:00:00

abstract：:There is increasing evidence that S-nitrosylation is a mechanism for the regulation of protein function via the modification of critical sulfhydryl groups. The activity of rat liver microsomal glutathione S-transferase (GST) is increased after treatment with N-ethylmaleimide (NEM), a sulfhydryl alkylating reagent, and...

journal_title：Biochemical pharmacology

authors： Ji Y,Toader V,Bennett BM

更新日期：2002-04-15 00:00:00

abstract：:Adiponectin blocks hepatocellular carcinoma (HCC) progression by inducing cell apoptosis through the modulation of C-Jun N-terminal kinase and mammalian target of rapamycin. However, the precise upstream signaling pathways or molecules remain elusive. In the present study, we analyzed the role of antioxidant protein t...

journal_title：Biochemical pharmacology

authors： Xing SQ,Zhang CG,Yuan JF,Yang HM,Zhao SD,Zhang H

更新日期：2015-01-15 00:00:00

abstract：:Nitroimidazoles labeled with technetium-99m are being investigated as non-invasive markers of tumor hypoxia. They are bioreductive compounds that require enzymatic reduction for retention in hypoxic cells, but little is known about the cellular factors affecting their accumulation in hypoxic cells. If the absolute acc...

journal_title：Biochemical pharmacology

authors： Melo T,Ballinger JR,Rauth AM

更新日期：2000-09-01 00:00:00

abstract：:A newly-synthesized derivative of prazosin, prazosinamine hydrochloride, was examined for its ability to antagonize the interaction of the alpha 1-adrenergic agonist phenylephrine with liver cells. Using a Ca2--selective electrode to measure changes in perfusate Ca2+ concentration, prazosinamine was found to be as eff...

journal_title：Biochemical pharmacology

authors： Armarego WL,Altin JG,Weir RC,Bygrave FL

更新日期：1987-05-15 00:00:00

abstract：:Uracil incorporation into DNA occurs under conditions that limit thymidine biosynthesis; uracil is removed by two isoforms of uracil DNA glycosylase (UNG; EC 3.2.2.3), UNG1 and UNG2. We hypothesize that UNG is important in protecting the mid-organogenesis stage [gestational day (GD) 10-12] rat conceptus against condit...

journal_title：Biochemical pharmacology

authors： Vinson RK,Hales BF

更新日期：2002-08-15 00:00:00

abstract：:The characterization of the potent p38 inhibitor BIRB796 as a dual inhibitor of p38/Jun N-terminal kinases (JNK) mitogen-activated protein kinases (EC 2.7.11.24) has complicated the interpretation of its reported anti-inflammatory activity. To better understand the contribution of JNK2 inhibition to the anti-inflammat...

journal_title：Biochemical pharmacology

authors： Gruenbaum LM,Schwartz R,Woska JR Jr,DeLeon RP,Peet GW,Warren TC,Capolino A,Mara L,Morelock MM,Shrutkowski A,Jones JW,Pargellis CA

更新日期：2009-02-01 00:00:00

abstract：:Surfaces of higher eukaryotes such as plants, invertebrates, and vertebrates, including humans, are normally covered with microorganisms but usually are not infected by them. The reason, apart from physical barriers, is the production of gene-encoded antimicrobial peptides by epithelial cells. Many novel antimicrobial...

journal_title：Biochemical pharmacology

authors： Schröder JM

更新日期：1999-01-15 00:00:00