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Suppressive effects of tranilast on the expression of inducible cyclooxygenase (COX2) in interleukin-1beta-stimulated fibroblasts.

Abstract：

:We investigated the effects of tranilast on inducible cyclooxygenase (COX2)-mediated prostaglandin E2 (PGE2) production and enzyme induction in interleukin-lbeta (IL-1beta)-stimulated cultured dermal fibroblasts. IL-1beta enhanced PGE2 production in cultured fibroblasts. Tranilast did not affect constitutive cyclooxygenase (COX1) or COX2 activity in non-stimulated or IL-lbeta-stimulated fibroblasts. However, the COX2 expression induced by IL-1beta was inhibited by tranilast. This result, that IL-1beta-induced COX2 expression was suppressed by tranilast, was confirmed by immunohistochemical analysis. Thus, it is possible for tranilast to regulate PGE2 production by inhibiting COX2 induction.

journal_name

Biochem Pharmacol

journal_title

Biochemical pharmacology

authors

Inoue H,Ohshima H,Kono H,Yamanaka M,Kubota T,Aihara M,Hiroi T,Yago N,Ishida H

doi

10.1016/s0006-2952(97)00187-1

subject

Has Abstract

pub_date

1997-06-15 00:00:00

pages

1941-4

issue

12

eissn

0006-2952

issn

1873-2968

pii

S0006295297001871

journal_volume

53

pub_type

杂志文章

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