Different effects of oxytetracycline and doxycycline on mitochondrial protein synthesis in rat liver after long-term treatment.

abstract：:We previously reported that RSV-transformed quail neuroretina cells (QNR-ts68) were highly resistant to apoptosis provoked by serum withdrawal, and that this property was due to v-Src kinase activity. The present study investigates the cytotoxic effect and the functional mechanism of carbazolequinone-mediated cell dea...

journal_title：Biochemical pharmacology

authors： Aouacheria A,Néel B,Bouaziz Z,Dominique R,Walchshofer N,Paris J,Fillion H,Gillet G

更新日期：2002-12-01 00:00:00

abstract：:Nitric oxide sensitive guanylyl cyclase (NOsGC) is a heterodimeric enzyme consisting of an α and a β subunit. Two heterodimeric enzymes are known to be important for NO-signalling in humans: α(1)/β(1) and α(2)/β(1). No difference had so far been detected with respect to their pharmacological properties, but as we show...

journal_title：Biochemical pharmacology

authors： Haase N,Haase T,Kraehling JR,Behrends S

更新日期：2010-12-01 00:00:00

abstract：:The substrate specificity of highly purified pig liver catechol-O-methyltransferase has been investigated kinetically. This enzyme shows stereospecificity towards the naturally occurring L-isomer of 3,4-dihydroxyphenylalanine (DOPA) which has a higher affinity and maximal velocity as a substrate than the D-form. We ha...

journal_title：Biochemical pharmacology

authors： Gordonsmith RH,Raxworthy MJ,Gulliver PA

更新日期：1982-02-01 00:00:00

abstract：:Class B peptide hormone GPCRs are targets for the treatment of major chronic disease. Peptide ligands of these receptors display biased agonism and this may provide future therapeutic advantage. Recent active structures of the calcitonin (CT) and glucagon-like peptide-1 (GLP-1) receptors reveal distinct engagement of ...

journal_title：Biochemical pharmacology

authors： Dal Maso E,Zhu Y,Pham V,Reynolds CA,Deganutti G,Hick CA,Yang D,Christopoulos A,Hay DL,Wang MW,Sexton PM,Furness SGB,Wootten D

更新日期：2018-04-01 00:00:00

abstract：:In this study we analyse the effects of the anti-tumor compound distamycin on the binding of nuclear factor(s) to a synthetic oligonucleotide (GTATA/IFN-gamma) mimicking a putative regulatory region of the human HLA-DR alpha gene. This region contains the sequence (GTATA), that is required for nuclear protein binding ...

journal_title：Biochemical pharmacology

authors： Gambari R,Barbieri R,Nastruzzi C,Chiorboli V,Feriotto G,Natali PG,Giacomini P,Arcamone F

更新日期：1991-02-15 00:00:00

abstract：:We demonstrated recently that phenethyl isothiocyanate (PEITC), a potent anticarcinogen present in cruciferous vegetables, inhibited P-glycoprotein (P-gp) and multidrug resistance protein 1 (MRP1) and that MRP1 can transport PEITC and/or its metabolites. In this study, we have examined whether PEITC is transported by ...

journal_title：Biochemical pharmacology

authors： Ji Y,Morris ME

更新日期：2005-08-15 00:00:00

abstract：:The metabolism of toluene in human liver microsomes and by cDNA-expressed human cytochrome P450s (CYPs) was investigated. Toluene was metabolized mainly to benzyl alcohol and slightly to o- and p-cresol by human liver microsomes. Formation of o-cresol was elevated in microsomes from human livers derived from cigarette...

journal_title：Biochemical pharmacology

authors： Nakajima T,Wang RS,Elovaara E,Gonzalez FJ,Gelboin HV,Raunio H,Pelkonen O,Vainio H,Aoyama T

更新日期：1997-02-07 00:00:00

abstract：:The study of binding is not an easy task especially because of the difficulty of interpreting the results in terms of binding on specific receptor sites. The problem is not new; what is new is the increasing amount of fanciful interpretation that such a technique has generated. The tendency to interpret anomalous or i...

journal_title：Biochemical pharmacology

authors： Laduron PM

更新日期：1984-03-15 00:00:00

abstract：:Microsomal and cytosolic epoxide hydrolase (mEH and cEH respectively) and glutathione S-transferase (GST) activities were measured in the liver, kidney, and gills of rainbow trout. Assays were optimized for time, pH, and temperature, using trans-stilbene oxide (TSO) and cis-stilbene oxide (CSO) as substrates for cEH a...

journal_title：Biochemical pharmacology

authors： Laurén DJ,Halarnkar PP,Hammcock BD,Hinton DE

更新日期：1989-03-15 00:00:00

abstract：:Curcumin (diferuloylmethane) is a well-known agent with anti-inflammatory, antioxidant, and anticarcinogenic properties. In this study, we observed that curcumin inhibited the kinase activity of v-Src, which led to a decrease in tyrosyl substrate phosphorylation of Shc, cortactin, and FAK. Our in vitro kinase experime...

journal_title：Biochemical pharmacology

authors： Leu TH,Su SL,Chuang YC,Maa MC

更新日期：2003-12-15 00:00:00

abstract：:The peptide hormone gastrin binds two ferric ions with high affinity, and iron binding is essential for the biological activity of non-amidated gastrins in vitro and in vivo. Bi3+ ions also bind to glycine-extended gastrin17 (Ggly), but inhibit Ggly-induced cell proliferation and migration in gastrointestinal cell lin...

journal_title：Biochemical pharmacology

authors： Kovac S,Loh SW,Lachal S,Shulkes A,Baldwin GS

更新日期：2012-02-15 00:00:00

abstract：:The characteristics of the muscarinic receptor in isolated gastric fundic cells from rabbit were determined by radioligand binding techniques and functional tests. The dissociation constants (KDS) of selective (hexahydrosiladifenidol and pirenzepine) and non-selective (N-methylscopolamine and atropine) muscarinic rece...

journal_title：Biochemical pharmacology

authors： Baudiere B,Monferini E,Giraldo E,Ladinsky H,Bali JP

更新日期：1987-09-15 00:00:00

abstract：:This study demonstrates that a long-lasting co-culture of neutrophil surrogates (HL-60 cells), minimally primed by platelet activating factor (PAF), and resting endothelial cells (EC) results in the elaboration of an hyper-adhesive endothelial surface, as measured by the increase in the expression of endothelial adhes...

journal_title：Biochemical pharmacology

authors： Allegra M,D'Acquisto F,Tesoriere L,Livrea MA,Perretti M

更新日期：2011-02-01 00:00:00

abstract：:Purified red blood cell cytosol is able to activate 2-aminofluorene (2AF) to N-hydroxy-2-aminofluorene. Apparent kinetic parameters are determined with and without methylene blue. The latter, which maintains haemoglobin in the reduced form and stimulates NADPH production, increases the affinity of the enzyme for the 2...

journal_title：Biochemical pharmacology

authors： Duverger-van Bogaert M,Wiame D,Stecca C

更新日期：1992-12-15 00:00:00

abstract：:Combining site-directed mutagenesis with information obtained from molecular modelling of the bradykinin (BK) human B2 receptor (hB2R) as derived from the bovine rhodopsin crystal structure [Science 289 (2000) 739], we previously defined a putative binding mode for the non-peptide B2 receptor antagonists, FR173657 and...

journal_title：Biochemical pharmacology

authors： Meini S,Cucchi P,Bellucci F,Catalani C,Faiella A,Rotondaro L,Quartara L,Giolitti A,Maggi CA

更新日期：2004-02-15 00:00:00

abstract：:The thermodynamic parameters DeltaG degrees , DeltaH degrees and DeltaS degrees of the binding equilibrium of agonists and antagonists at cannabinoid CB(1) and CB(2) receptors were determined by means of affinity measurements at different temperatures and van't Hoff plots were constructed. Affinity constants were meas...

journal_title：Biochemical pharmacology

authors： Merighi S,Simioni C,Gessi S,Varani K,Borea PA

更新日期：2010-02-01 00:00:00

abstract：:The influence of age on the mixed function oxidase system from a non-human primate was studied. Microsomes were isolated from the livers of female Macaca nemestrina ranging from 2 to 21 years of age. No significant age-related change was observed in either the cytochrome P-450 content or the NADPH cytochrome c reducta...

journal_title：Biochemical pharmacology

authors： Sutter MA,Wood WG,Williamson LS,Strong R,Pickham K,Richardson A

更新日期：1985-08-15 00:00:00

abstract：:We have shown previously that bis(N,N-dimethylhydroxamido)hydroxooxovanadate (DMHV) is an excellent reversible inhibitor of protein tyrosine phosphatase (PTP) in vitro. DMHV does not carry a charge under physiological pH conditions and is anticipated to permeate cell membranes more easily than vanadate. In the present...

journal_title：Biochemical pharmacology

authors： Cuncic C,Desmarais S,Detich N,Tracey AS,Gresser MJ,Ramachandran C

更新日期：1999-12-15 00:00:00

abstract：:This review has highlighted some of the well-described differences in endothelial cells derived from different sites of the vascular tree. In presenting a select group of endothelial properties, there was no intention to imply that these are the only properties of endothelial cells that exhibit heterogeneity. Nonethel...

journal_title：Biochemical pharmacology

authors： Gerritsen ME

更新日期：1987-09-01 00:00:00

abstract：:The remarkable effects exhibited by classical psychedelics in recent clinical trials have spawned considerable interest in 5-HT2A receptor (5-HT2AR) activation as a treatment strategy for several psychiatric/cognitive disorders. In this study we have continued our development of 25CN-NBOH, one of the most 5-HT2AR-sele...

journal_title：Biochemical pharmacology

authors： Jensen AA,Halberstadt AL,Märcher-Rørsted E,Odland AU,Chatha M,Speth N,Liebscher G,Hansen M,Bräuner-Osborne H,Palner M,Andreasen JT,Kristensen JL

更新日期：2020-07-01 00:00:00

abstract：:An intestinal active transport system specific to small peptides and peptide-like drugs such as beta-lactam antibiotics was functionally expressed in Xenopus laevis oocytes after microinjection of messenger RNA (mRNA) derived from rat intestinal mucosal cells. The transport activity was evaluated by measuring the upta...

journal_title：Biochemical pharmacology

authors： Tamai I,Tomizawa N,Kadowaki A,Terasaki T,Nakayama K,Higashida H,Tsuji A

更新日期：1994-08-30 00:00:00

abstract：:We investigated the amplification of bleomycin-induced DNA cleavage by synthetic triamides containing N-methylpyrrole (Py) and/or N-methylimidazole (Im), PyPyPy, PyPyIm, PyImPy, and PyImIm, using 32P-labeled DNA fragments obtained from the human c-Ha-ras-1 and p53 genes. Peplomycin, a bleomycin analog, plus Fe(II) cau...

journal_title：Biochemical pharmacology

authors： Hiraku Y,Oikawa S,Kuroki K,Sugiyama H,Saito I,Kawanishi S

更新日期：2001-02-01 00:00:00

abstract：:The advent of drugs targeting tumor-associated prosurvival alterations of cancer cells has changed the interest of antitumor drug development from cytotoxic drugs to target-specific agents. Although single-agent therapy with molecularly targeted agents has shown limited success in tumor growth control, a promising str...

journal_title：Biochemical pharmacology

authors： Perego P,Cossa G,Zuco V,Zunino F

更新日期：2010-11-15 00:00:00

abstract：:The fallen concentration of one of the two isomers of soman (1,2,2-trimethylpropyl methylphosphonofluoridate), i.e., C(+)P(-)-soman, was investigated in plasma and in homogenates of brain, lung, liver, kidney, diaphragm, skeletal muscle and mucosa of small intestines from rat, guinea pig and marmoset, and in human pla...

journal_title：Biochemical pharmacology

authors： de Jong LP,van Dijk C,Berhitoe D,Benschop HP

更新日期：1993-10-19 00:00:00

abstract：:There is increasing evidence that S-nitrosylation is a mechanism for the regulation of protein function via the modification of critical sulfhydryl groups. The activity of rat liver microsomal glutathione S-transferase (GST) is increased after treatment with N-ethylmaleimide (NEM), a sulfhydryl alkylating reagent, and...

journal_title：Biochemical pharmacology

authors： Ji Y,Toader V,Bennett BM

更新日期：2002-04-15 00:00:00

abstract：:Extracellular nicotinamide is well recognized as the primary precursor to the cellular synthesis of NAD. NAD is a pivotal molecule in regulating the energy and redox potentials of cells via synthesis of ATP and NAD(P)/NAD(P)H ratios. NAD turnover in cells is very rapid due to NAD catabolism via ADP-ribosylation reacti...

journal_title：Biochemical pharmacology

authors： Olsson A,Olofsson T,Pero RW

更新日期：1993-03-24 00:00:00

abstract：:Mitochondrial carriers are proteins that shuttle a variety of metabolites, nucleotides and coenzymes across the inner mitochondrial membrane. The mitochondrial ADP/ATP carriers (AACs) specifically translocate the ATP synthesized within mitochondria to the cytosol in exchange for the cytosolic ADP, playing a key role i...

journal_title：Biochemical pharmacology

authors： Todisco S,Di Noia MA,Onofrio A,Parisi G,Punzi G,Redavid G,De Grassi A,Pierri CL

更新日期：2016-01-15 00:00:00

abstract：:Tumor-induced neoangiogenesis is an essential event for solid tumor growth. Therefore, a compound able to block angiogenesis-promoting factors could have antitumor activity. The polysulfonated naphthylurea suramin is hypothesized to have this mode of action. A series of sulfonated distamycin A derivatives have been sy...

journal_title：Biochemical pharmacology

authors： Ciomei M,Pastori W,Mariani M,Sola F,Grandi M,Mongelli N

更新日期：1994-01-20 00:00:00

abstract：:Alone and in synergistic combination with retinoids, dietary glucarate inhibits both the chemical induction and growth of rat mammary tumors. To investigate the pharmacokinetics of glucarate, [14C]glucarate was synthesized, converted to the calcium salt, and administered to rats bearing primary mammary tumors. When gi...

journal_title：Biochemical pharmacology

authors： Webb TE,Pham-Nguyen MH,Darby M,Hamme AT 2nd

更新日期：1994-04-29 00:00:00

abstract：:Diethyl maleate (DEM) was given intraperitoneally to rats in a dose (4.3 mmoles/kg) known to markedly decrease glutathione levels in liver. DEM induced a choleresis previously shown to be due to the osmotic activity of DEM conjugates (DEM-glutathione and subsequent metabolic products) excreted into bile. Coincident wi...

journal_title：Biochemical pharmacology

authors： Combes B,Backof B

更新日期：1982-08-15 00:00:00