[Treatment of systemic arterial hypertension with urapidil. Study in mild and moderate hypertension with ambulatory monitoring of arterial pressure].

Abstract:

PURPOSE:To study the efficacy and tolerability of urapidil in patients with mild and moderate arterial hypertension, including ambulatory blood pressure monitoring (ABPM). METHODS:Twenty patients, either sex, 40 to 75 years old, with diastolic blood pressure (DBP) between 90 to 115mmHg were studied. The DBP was the follow-up criterion measured by conventional esphygmomanometer. The 24 hours ambulatory monitoring of BP was made to observe its variation. After wash-out of 15 days, urapidil was administered starting with 60 mg/day, during two weeks, followed by 120mg/day and 180mg/day if necessary, to achieve th protocol baseline of 90mmHg or less of DBP. It followed 8 weeks treatment. Laboratory tests, EKG, monitoring of BP and clinical evaluation was made at pre and post treatment period, with clinical examinations every two weeks. RESULTS:In 15 (75%) patients the BP was controlled according to the protocol criteria (p < 0.001). The control of BP was not achieved in 3 (15%) and 2 (10%) patients were withdrawn because of intolerable drug side effects. The most frequent side effects were nausea, dizziness and indisposition, but 60% of the patients did not present any one. The duration of side effects was not longer than to 30 days, except in one patient. There were no changes in laboratory results after the treatment period. The 24 hours ABPM showed an improvement in the pattern of hypertension, maintaining the BP circadian rhythm. CONCLUSION:Urapidil demonstrated to be effective and safe in the treatment of patients with mild and moderate arterial hypertension, showing good control of BP levels, without changing the laboratory parameters.

journal_name

Arq Bras Cardiol

authors

Nobre F,Nogueira JL

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

63-8

issue

1

eissn

0066-782X

issn

1678-4170

journal_volume

61

pub_type

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